摘要:
This is to provide a novel aniline compound represented by the following formula (I) having an excellent broncho dilatory action based on potent EP2 agonistic action.A compound represented by the formula (I): or a salt thereof.
摘要:
This is to provide a novel substituted carbonyl compound represented by the following formula (I) having an excellent bronchodilatory action based on potent EP2 agonistic action and useful for treatment of respiratory diseases.A compound represented by the following formula (I): or a salt thereof.
摘要:
The present invention is to provide a medical composition for the treatment or prophylaxis of glaucoma which comprises a pyridylaminoacetic acid compound represented by the formula (1): wherein R1, R2, R3, Y, and Z are defined in the specification.
摘要:
The present invention discloses a dibenzocycloheptene compound represented by the formula (I): wherein R1: hydrogen atom, halogen atom, etc., R2: hydrogen atom, halogen atom, etc., A: 5-membered or 6-membered heteroaromatic ring group containing 1 to 3 hetero atom(s) selected from the group consisting of nitrogen atom, oxygen atom and sulfur atom, and the heteroaromatic ring group, etc. may have halogen atom, nitrogen atom, etc. as substituent(s), B: formula; —CH═CH—, formula; —CH2O—, etc., Y: C1-C10 alkylene group which may have halogen atom, etc. as substituent(s), etc., Z: carboxyl group which may be protected, etc., m: an integer of 1 to 4, n: an integer of 1 to 3, represents a single bond or a double bond, or a pharmaceutically acceptable salt thereof and a medical composition containing the same as an effective ingredient which has leukotriene C4 antagonistic action and leukotriene E4 antagonistic action in addition to potent leukotriene D4 antagonistic action, and useful as antiasthmatic agent, antiallergic agent and anti-inflammatory agent.
摘要翻译:本发明公开了式(I)表示的二苯并环庚烯化合物:其中R 1:氢原子,卤素原子等,R 2:氢原子,卤素原子 等,含有1〜3个选自氮原子,氧原子和硫原子的杂原子的5元或6元杂芳族环基和杂芳环基等可以具有 卤素原子,氮原子等作为取代基,B:式; -CH-CH-,式 -CH 2 O - 等,Y:C 1 -C 10亚烷基,其可以具有卤素原子等作为取代基( s)等,Z:可被保护的羧基等,m:1〜4的整数,n:1〜3的整数,表示单键或双键 ,或其药学上可接受的盐和含有与有效成分相同的药物组合物,除了有效的白三烯外,还具有白三烯C 4拮抗作用和白三烯E 4拮抗作用 D 4拮抗作用,可用作止喘剂,抗过敏剂和抗炎剂。
摘要:
The present invention is to provide a medical composition for the treatment or prophylaxis of glaucoma which comprises a pyridylaminoacetic acid compound represented by the formula (1): wherein R1, R2 and R3 each independently represent a hydrogen atom or C1-C6 alkyl group, Y represents a bicyclic heteroaromatic ring group which may be substituted by a group(s) selected from the group consisting of a halogen atom, C1-C6 alkyl group, halogeno C1-C6 alkyl group, C1-C6 alkoxyl group, halogeno C1-C6 alkoxyl group and C1-C6 alkylthio group or a group -Q1-Q2 wherein Q1 represents an arylene group or 5- to 6-membered heteroarylene group, Q2 represents an aromatic group or a 5- to 6-membered ring heterocyclic group each of which may be substituted by a group(s) selected from the group consisting of a halogen atom, hydroxyl group, C1-C6 alkyl group, halogeno C1-C6 alkyl group, C1-C6 alkoxyl group and halogeno C1-C6 alkoxyl group, Z represents an aromatic group or a 5- to 6-membered heteroaromatic ring group each of which may be substituted by a group(s) selected from the group consisting of a halogen atom, C1-C6 alkyl group, halogeno C1-C6 alkyl group, C1-C6 alkoxyl group and halogeno C1-C6 alkoxyl group, or a pharmaceutically acceptable salt thereof as an effective ingredient.
摘要:
The present invention discloses a pyrrolopyridazinone compound represented by the formula (1): useful, for example, as an anti-inflammatory agent or an inhibitor of respiratory tract contraction.
摘要:
The present invention provides a substituted pyridine compound or a pharmacologically acceptable salt thereof which has excellent CETP inhibition activity and is useful as a medicament. The present invention provides a compound represented by a general formula (I), wherein R1 is H, optionally substituted alkyl, OH, optionally substituted alkoxy, alkylsulfonyl, optionally substituted amino, carboxy, optionally substituted carbonyl, CN, halogeno, optionally substituted phenyl, optionally substituted aromatic heterocyclyl, optionally substituted saturated heterocyclyl, optionally substituted saturated heterocyclyloxy or optionally substituted saturated heterocyclylcarbonyl, etc., and the like.
摘要:
The present invention is directed to providing prasugrel hydrochloride or the like with a reduced content of OXTP. A method for producing prasugrel hydrochloride with a reduced content of OXTP, comprising dissolving free prasugrel containing OXTP in an inert solvent and adding hydrochloric acid optionally dropwise to the solution for reaction is also provided.
摘要:
The present invention is to provide a medical composition for the treatment or prophylaxis of diseases caused by angiogenesis of eyes which comprises a compound represented by the following formula (I): wherein R1 represents a C1-C6 alkyl group or halogeno-C1-C6alkyl group, R2 represents a carboxyl group which may be protected, and Y represents a group represented by the formula (II): wherein Z represents CH or nitrogen atom, or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译:本发明提供一种用于治疗或预防由眼睛血管生成引起的疾病的医药组合物,其包含由下式(I)表示的化合物:其中R1表示C1-C6烷基或卤代-C1-C6烷基 R 2表示可被保护的羧基,Y表示由式(II)表示的基团:其中Z表示CH或氮原子,或其药学上可接受的盐作为活性成分。
摘要:
An object of the present invention is to create a novel indazole derivative having a spiro ring structure in a side chain, which is useful as a pharmaceutical, and to find a new pharmacological activity of the derivative. The present invention compound is represented by the general formula [I] and has an excellent Rho kinase inhibitory activity. In the formula, the ring X represents a benzene ring or a pyridine ring; R1 and R2 represent halogen, H, OH, alkoxy, cycloalkyloxy, aryloxy, alkyl, cycloalkyl or the like; R3 represents halogen, H or the like; R4 and R5 represent halogen, H or the like; R6 and R7 represent H, alkyl or the like; and m, n, p and q represent an integer of 0 to 3. In this connection, each group may have a substituent.
摘要翻译:本发明的目的是在侧链中产生具有螺环结构的新型吲唑衍生物,其可用作药物,并找到衍生物的新药理活性。 本发明化合物由通式[I]表示,具有优异的Rho激酶抑制活性。 在该式中,环X表示苯环或吡啶环; R 1和R 2表示卤素,H,OH,烷氧基,环烷氧基,芳氧基,烷基,环烷基等; R3表示卤素,H等; R4和R5表示卤素,H等; R6和R7代表H,烷基等; m,n,p和q表示0〜3的整数。就此而言,各基团可以具有取代基。