公开(公告)号：US20070158195A1

公开(公告)日：2007-07-12

申请号：US11714222

申请日：2007-03-06

申请人： Ryoji Inaba ,  Tomohiro Shoji ,  Shozo Kasai ,  Masaya Kojima ,  Yasushi Shimizu ,  Seiichi Ugai ,  Eric Nordman

发明人： Ryoji Inaba ,  Tomohiro Shoji ,  Shozo Kasai ,  Masaya Kojima ,  Yasushi Shimizu ,  Seiichi Ugai ,  Eric Nordman

IPC分类号： G01N27/00

CPC分类号： G01N27/44782 ,  G01N27/44721

摘要： An electrophoresis apparatus includes a multi-capillary array having a liquid or solid disposed between the capillaries of the array. The liquid or solid exhibits a refractive index higher than that of air and less than that of water and reduces the amount of laser beams scattered by the capillaries. Also provided are methods of adjusting refracted and reflected excitation light beams passing through capillaries of a multi-capillary array, to reduce loss of intensity of the laser beams and increase irradiation of respective samples disposed in the capillaries.

公开(公告)号：US08246806B2

公开(公告)日：2012-08-21

申请号：US11714222

申请日：2007-03-06

申请人： Ryoji Inaba ,  Tomohiro Shoji ,  Shozo Kasai ,  Masaya Kojima ,  Yasushi Shimizu ,  Seiichi Ugai ,  Eric S. Nordman

发明人： Ryoji Inaba ,  Tomohiro Shoji ,  Shozo Kasai ,  Masaya Kojima ,  Yasushi Shimizu ,  Seiichi Ugai ,  Eric S. Nordman

IPC分类号： G01N27/453

CPC分类号： G01N27/44782 ,  G01N27/44721

摘要： An electrophoresis apparatus includes a multi-capillary array having a liquid or solid disposed between the capillaries of the array. The liquid or solid exhibits a refractive index higher than that of air and less than that of water and reduces the amount of laser beams scattered by the capillaries. Also provided are methods of adjusting refracted and reflected excitation light beams passing through capillaries of a multi-capillary array, to reduce loss of intensity of the laser beams and increase irradiation of respective samples disposed in the capillaries.

摘要翻译： 电泳装置包括具有设置在阵列的毛细管之间的液体或固体的多毛细管阵列。 液体或固体的折射率高于空气的折射率，小于水的折射率，并减少了由毛细管散射的激光束的数量。 还提供了调节通过多毛细管阵列的毛细管的折射和反射的激发光束的方法，以减少激光束的强度损失并增加设置在毛细管中的各个样品的照射。

公开(公告)号：US07250098B2

公开(公告)日：2007-07-31

申请号：US10259492

申请日：2002-09-30

申请人： Ryoji Inaba ,  Tomohiro Shoji ,  Shozo Kasai ,  Masaya Kojima ,  Yasushi Shimizu ,  Seiichi Ugai

发明人： Ryoji Inaba ,  Tomohiro Shoji ,  Shozo Kasai ,  Masaya Kojima ,  Yasushi Shimizu ,  Seiichi Ugai

IPC分类号： G01N27/453

CPC分类号： G01N27/44782 ,  G01N27/44721

摘要： An electrophoresis apparatus includes a multi-capillary array having a liquid or solid disposed between the capillaries of the array. The liquid or solid exhibits a refractive index higher than that of air and less than that of water and reduces the amount of laser beams scattered by the capillaries. Also provided are methods of adjusting refracted and reflected excitation light beams passing through capillaries of a multi-capillary array, to reduce loss of intensity of the laser beams and increase irradiation of respective samples disposed in the capillaries.

摘要翻译： 电泳装置包括具有设置在阵列的毛细管之间的液体或固体的多毛细管阵列。 液体或固体的折射率高于空气的折射率，小于水的折射率，并减少了由毛细管散射的激光束的数量。 还提供了调节通过多毛细管阵列的毛细管的折射和反射的激发光束的方法，以减少激光束的强度损失并增加设置在毛细管中的各个样品的照射。

公开(公告)号：US08043493B2

公开(公告)日：2011-10-25

申请号：US11714221

申请日：2007-03-06

申请人： Ryoji Inaba ,  Tomohiro Shoji ,  Shozo Kasai ,  Masaya Kojima ,  Yasushi Shimizu ,  Seiichi Ugai

发明人： Ryoji Inaba ,  Tomohiro Shoji ,  Shozo Kasai ,  Masaya Kojima ,  Yasushi Shimizu ,  Seiichi Ugai

IPC分类号： G01N27/453

CPC分类号： G01N27/44782 ,  G01N27/44721

摘要： An electrophoresis apparatus includes a multi-capillary array having a liquid or solid disposed between the capillaries of the array. The liquid or solid exhibits a refractive index higher than that of air and less than that of water and reduces the amount of laser beams scattered by the capillaries. Also provided are methods of adjusting refracted and reflected excitation light beams passing through capillaries of a multi-capillary array, to reduce loss of intensity of the laser beams and increase irradiation of respective samples disposed in the capillaries.

摘要翻译： 电泳装置包括具有设置在阵列的毛细管之间的液体或固体的多毛细管阵列。 液体或固体的折射率高于空气的折射率，小于水的折射率，并减少了由毛细管散射的激光束的数量。 还提供了调节通过多毛细管阵列的毛细管的折射和反射的激发光束的方法，以减少激光束的强度损失并增加设置在毛细管中的各个样品的照射。

公开(公告)号：US07883613B2

公开(公告)日：2011-02-08

申请号：US11806889

申请日：2007-06-05

申请人： Takashi Gomi ,  Ryoji Inaba ,  Motohiro Yamazaki ,  Hidenori Namba ,  Jin Matsumura ,  Hiromi Yamashita ,  Seiichi Ugai ,  Kazumichi Imai

发明人： Takashi Gomi ,  Ryoji Inaba ,  Motohiro Yamazaki ,  Hidenori Namba ,  Jin Matsumura ,  Hiromi Yamashita ,  Seiichi Ugai ,  Kazumichi Imai

IPC分类号： G01N27/453

CPC分类号： G01N27/44721

摘要： The present invention provides a capillary electrophoresis apparatus in which a capillary is easily attached to and detached from a migration medium filling unit without mixing impurities into the capillary. Mixture of impurities such as dust is also prevented when a capillary negative-electrode end is brought into contact with a sample stored in a vessel. Furthermore, temperature control is efficiently performed in the capillary. In the capillary electrophoresis apparatus, the whole of capillary array can be supported by grasping a grip portion by hand. A migration medium filling mechanism includes a slide mechanism which moves a polymer block with respect to a capillary head. The capillary electrophoresis apparatus includes a vessel in which a sample and a buffer can simultaneously be stored. Temperatures of the capillary and an irradiation and detection unit are controlled by a temperature control function provided in a thermostatic device.

摘要翻译： 本发明提供了一种毛细管电泳装置，其中毛细管容易地连接到迁移介质填充单元并从迁移介质填充单元中分离而不将杂质混入毛细管中。 当毛细管负极端与存储在容器中的样品接触时，也可以防止诸如灰尘等杂质的混合物。 此外，在毛细管中有效地进行温度控制。 在毛细管电泳装置中，通过用手抓握把手部分可以支撑整个毛细管阵列。 迁移介质填充机构包括相对于毛细管头移动聚合物嵌段的滑动机构。 毛细管电泳装置包括可以同时存储样品和缓冲液的容器。 毛细管和照射和检测单元的温度由恒温装置中提供的温度控制功能控制。

公开(公告)号：US20070278101A1

公开(公告)日：2007-12-06

申请号：US11806889

申请日：2007-06-05

申请人： Takashi Gomi ,  Ryoji Inaba ,  Motohiro Yamazaki ,  Hidenori Namba ,  Jin Matsumura ,  Hiromi Yamashita ,  Seiichi Ugai ,  Kazumichi Imai

发明人： Takashi Gomi ,  Ryoji Inaba ,  Motohiro Yamazaki ,  Hidenori Namba ,  Jin Matsumura ,  Hiromi Yamashita ,  Seiichi Ugai ,  Kazumichi Imai

IPC分类号： G01N27/00

CPC分类号： G01N27/44721

摘要： The present invention provides a capillary electrophoresis apparatus in which a capillary is easily attached to and detached from a migration medium filling unit without mixing impurities into the capillary. Mixture of impurities such as dust is also prevented when a capillary negative-electrode end is brought into contact with a sample stored in a vessel. Furthermore, temperature control is efficiently performed in the capillary. In the capillary electrophoresis apparatus, the whole of capillary array can be supported by grasping a grip portion by hand. A migration medium filling mechanism includes a slide mechanism which moves a polymer block with respect to a capillary head. The capillary electrophoresis apparatus includes a vessel in which a sample and a buffer can simultaneously be stored. Temperatures of the capillary and an irradiation and detection unit are controlled by a temperature control function provided in a thermostatic device.

摘要翻译： 本发明提供了一种毛细管电泳装置，其中毛细管容易地附着到迁移介质填充单元上并从迁移介质填充单元中分离而不将杂质混入毛细管中。 当毛细管负极端与存储在容器中的样品接触时，也可以防止诸如灰尘等杂质的混合物。 此外，在毛细管中有效地进行温度控制。 在毛细管电泳装置中，通过用手抓握把手部分可以支撑整个毛细管阵列。 迁移介质填充机构包括相对于毛细管头移动聚合物嵌段的滑动机构。 毛细管电泳装置包括可以同时存储样品和缓冲液的容器。 毛细管和照射和检测单元的温度由恒温装置中提供的温度控制功能控制。

公开(公告)号：US20060219559A1

公开(公告)日：2006-10-05

申请号：US11395158

申请日：2006-04-03

申请人： Seiichi Ugai ,  Tomonari Morioka ,  Ryoji Inaba ,  Akihiro Suzuki ,  Yoshinori Ookoshi ,  Yoshiyuki Okishima ,  Tsukasa Ohira ,  Motohiro Yamazaki ,  Takashi Gomi

发明人： Seiichi Ugai ,  Tomonari Morioka ,  Ryoji Inaba ,  Akihiro Suzuki ,  Yoshinori Ookoshi ,  Yoshiyuki Okishima ,  Tsukasa Ohira ,  Motohiro Yamazaki ,  Takashi Gomi

IPC分类号： G01N27/00

CPC分类号： G01N27/44708

摘要： In a case where the temperature of capillaries cannot be controlled rapidly in accordance with the change of the amount of heat generated from the capillaries, the phoretic speed of the sample is not controlled constant to lower the analyzing performance for the sample. This invention intends to stabilize the electrophoretic speed. The surface of a substrate on which a plurality of capillaries are arranged is in contact with a member capable of temperature control thereby controlling the temperature of the capillaries. Since a member capable of controlling the temperature and the capillaries are in direct contact with each other according to the invention, the temperature of the capillary can be controlled rapidly at a high accuracy, so that electrophoretic speed is stabilized.

公开(公告)号：US07473342B2

公开(公告)日：2009-01-06

申请号：US11395158

申请日：2006-04-03

申请人： Seiichi Ugai ,  Tomonari Morioka ,  Ryoji Inaba ,  Akihiro Suzuki ,  Yoshinori Ookoshi ,  Yoshiyuki Okishima ,  Tsukasa Ohira ,  Motohiro Yamazaki ,  Takashi Gomi

发明人： Seiichi Ugai ,  Tomonari Morioka ,  Ryoji Inaba ,  Akihiro Suzuki ,  Yoshinori Ookoshi ,  Yoshiyuki Okishima ,  Tsukasa Ohira ,  Motohiro Yamazaki ,  Takashi Gomi

IPC分类号： G01N27/00

CPC分类号： G01N27/44708

摘要： In a case where the temperature of capillaries cannot be controlled rapidly in accordance with the change of the amount of heat generated from the capillaries, the phoretic speed of the sample is not controlled constant to lower the analyzing performance for the sample. This invention intends to stabilize the electrophoretic speed. The surface of a substrate on which a plurality of capillaries are arranged is in contact with a member capable of temperature control thereby controlling the temperature of the capillaries. Since a member capable of controlling the temperature and the capillaries are in direct contact with each other according to the invention, the temperature of the capillary can be controlled rapidly at a high accuracy, so that electrophoretic speed is stabilized.

摘要翻译： 在毛细管的温度不能根据毛细管产生的热量的变化而不能快速控制的情况下，不将样品的凝胶速度控制在一定程度以降低样品的分析性能。 本发明旨在稳定电泳速度。 其上布置有多个毛细管的基板的表面与能够进行温度控制的构件接触，从而控制毛细管的温度。 由于根据本发明能够控制温度和毛细管的构件彼此直接接触，所以可以高精度地快速地控制毛细管的温度，使得电泳速度稳定。

公开(公告)号：US20060076239A1

公开(公告)日：2006-04-13

申请号：US11245491

申请日：2005-10-07

申请人： Ryoji Inaba ,  Motohiro Yamazaki ,  Akihiro Suzuki ,  Miho Ozawa ,  Daizo Tokinaga ,  Tomonari Morioka ,  Seiichi Ugai

发明人： Ryoji Inaba ,  Motohiro Yamazaki ,  Akihiro Suzuki ,  Miho Ozawa ,  Daizo Tokinaga ,  Tomonari Morioka ,  Seiichi Ugai

IPC分类号： G01N27/447

CPC分类号： G01N27/447

摘要： In an electrophoresis apparatus comprising capillaries for containing therein fluorescence-labeled substances, and a sensor for irradiating the capillaries with exciting light and detecting fluorescences, the sensor has a substrate including a datum surface for holding thereon the capillaries, and a groove sinking from the datum surface, and the groove has a plurality of reflecting surfaces for reflecting thereon the fluorescences emitted from the capillaries by a plurality of times.

摘要翻译： 在包括用于在其中含有荧光标记物质的毛细管的电泳装置和用于用激发光照射毛细管并检测荧光的传感器中，传感器具有包括用于保持毛细管的基准表面的基底和从基准面凹下的凹槽 表面，并且凹槽具有多个反射表面，用于在其上反射从毛细管发射的荧光多次。

公开(公告)号：US06878256B2

公开(公告)日：2005-04-12

申请号：US10100009

申请日：2002-03-19

申请人： Syouzou Kasai ,  Yoshiyuki Okishima ,  Tomonari Morioka ,  Yasushi Shimizu ,  Hiroyuki Tanaka ,  Takayasu Furukawa ,  Noriyuki Shimoda ,  Seiichi Ugai

发明人： Syouzou Kasai ,  Yoshiyuki Okishima ,  Tomonari Morioka ,  Yasushi Shimizu ,  Hiroyuki Tanaka ,  Takayasu Furukawa ,  Noriyuki Shimoda ,  Seiichi Ugai

IPC分类号： G01N27/447 ,  G01N27/453

CPC分类号： G01N27/44704 ,  G01N27/44743 ,  G01N27/44782

摘要： The present invention easies a connection between electrodes of a capillary array device and a connection plate for supplying a high voltage to the electrodes.According to the present invention, a connection plate 23 and hollow electrodes 20 are connected without solder but via a spring force. Alternatively, the hollow electrodes 20 can be connected to the connection plate 23 by utilizing volume elasticity of the connection plate.

摘要翻译： 本发明简化了毛细管阵列器件的电极和用于向电极提供高电压的连接板之间的连接。根据本发明，连接板23和中空电极20没有焊料而是通过弹簧力连接。 或者，中空电极20可以通过利用连接板的体积弹性而连接到连接板23。