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    Thieno[2,3-d]pyrimidine derivatives and salts thereof
    8.
    发明授权
    Thieno[2,3-d]pyrimidine derivatives and salts thereof 失效
    噻吩并[2,3-d]嘧啶衍生物及其盐

    公开(公告)号：US4695568A

    公开(公告)日：1987-09-22

    申请号：US685768

    申请日：1984-12-24

    申请人： Kunihiro Ninomiya ,  Issei Nitta ,  Akihiro Tobe ,  Mitsuo Egawa ,  Ryoji Kikumoto

    发明人： Kunihiro Ninomiya ,  Issei Nitta ,  Akihiro Tobe ,  Mitsuo Egawa ,  Ryoji Kikumoto

    IPC分类号： A61K31/505 ,  A61K31/55 ,  A61P25/24 ,  A61P25/26 ,  A61P25/28 ,  C07D495/04 ,  A61K31/38 ,  C07D239/00

    CPC分类号： C07D495/04

    摘要： This invention relates novel thieno[2,3-d]pyrimidine derivatives represented by the following general formula (I): ##STR1## or salts thereof; wherein R.sup.1 and R.sup.2 independently represent hydrogen, halogen or alkyl group having 1 to 6 carbon atoms; or R.sup.1 and R.sup.2 may concatenate to form a cycloalkylene group having 5 or 6 ring carbon atoms; R.sup.3 and R.sup.4 independently represent hydrogen or alkyl group having 1 to 6 carbon atoms; R.sup.5 represents a member selected from(1) hydrogen or alkyl having 1 to 6 carbon atoms,(2) ##STR2## in which m is an integer of from 1 to 3 and X represents halogen, or (3) ##STR3## in which R.sup.6 represents alkyl group having 1 to 6 carbon atoms; Ar represents substituted or unsubstituted phenyl, or 2- or 3-thienyl group; and n is 2 or 3. The derivatives of the invention can be used in the treatment of the various depression disease or the higher dysfunction of the brain.

    摘要翻译： 本发明涉及由以下通式（I）表示的新颖的噻吩并[2,3-d]嘧啶衍生物或其盐; 其中R 1和R 2独立地表示氢，卤素或具有1至6个碳原子的烷基; 或者R1和R2可以连接形成具有5或6个环碳原子的亚环烷基; R3和R4独立地表示氢或具有1-6个碳原子的烷基; R5表示选自（1）氢或具有1至6个碳原子的烷基的成员，（2）其中m是1至3的整数，X表示卤素，或（3）其中 R6代表具有1-6个碳原子的烷基; Ar表示取代或未取代的苯基，或2-或3-噻吩基; 并且n为2或3.本发明的衍生物可用于治疗各种抑郁症或较高的脑功能障碍。