-
公开(公告)号:US20120020962A1
公开(公告)日:2012-01-26
申请号:US13225811
申请日:2011-09-06
申请人: Ryuzo UEDA , Kenya SHITARA , Shiro AKINAGA , Rinpei NIWA , Masamichi KOIKE
发明人: Ryuzo UEDA , Kenya SHITARA , Shiro AKINAGA , Rinpei NIWA , Masamichi KOIKE
CPC分类号: C07K16/2866 , A61K2039/505 , C07K2317/24 , Y02A50/41 , Y02A50/412
摘要: The present invention relates to the method for depleting in vivo regulatory T cell, the method for suppressing IL-10 producing activity of regulatory T cell, the method for treating diseases in which pathologic conditions are deteriorated by regulatory T cell and the method for enhancing tumor immunity which comprises administering to a patient a monoclonal antibody which specifically binds to human CC chemokine 4 (CCR4) or the antibody fragment thereof.
摘要翻译: 本发明涉及体内调节性T细胞的消耗方法,抑制调节性T细胞的IL-10产生活性的方法,通过调节性T细胞治疗病变状态的疾病的治疗方法及增强肿瘤的方法 其包括向患者施用特异性结合人CC趋化因子4(CCR4)或其抗体片段的单克隆抗体。