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公开(公告)号:US20090247559A1
公开(公告)日:2009-10-01
申请号:US12341210
申请日:2008-12-22
申请人: S. David Brown , Hongwang Du , Maurizio Franzini , Adam Antoni Galan , Ping Huang , Patrick Kearney , Moon Hwan Kim , Elena S. Koltun , Steven James Richards , Amy L. Tsuhako , Cristiana A. Zaharia
发明人: S. David Brown , Hongwang Du , Maurizio Franzini , Adam Antoni Galan , Ping Huang , Patrick Kearney , Moon Hwan Kim , Elena S. Koltun , Steven James Richards , Amy L. Tsuhako , Cristiana A. Zaharia
IPC分类号: A61K31/519 , C07D487/04 , A61P35/00
CPC分类号: C07D491/04
摘要: A compound according to formula I: or a pharmaceutically acceptable salt thereof; wherein R1, R2, R3a, R3b, R3c and R3d are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof.
摘要翻译: 根据式I的化合物或其药学上可接受的盐; 其中R1,R2,R3a,R3b,R3c和R3d如说明书中所定义,其药物组合物及其使用方法。
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公开(公告)号:US08324231B2
公开(公告)日:2012-12-04
申请号:US12597271
申请日:2008-04-24
申请人: Elena S. Koltun , Patrick Kearney , Naing Aay , Arlyn Arcalas , Wai Ki Vicky Chan , Jeffry Kimo Curtis , Hongwang Du , Ping Huang , Brian Kane , Moon Hwan Kim , Michael Pack , Amy L. Tsuhako , Wei Xu , Cristiana A. Zaharia , Peiwen Zhou
发明人: Elena S. Koltun , Patrick Kearney , Naing Aay , Arlyn Arcalas , Wai Ki Vicky Chan , Jeffry Kimo Curtis , Hongwang Du , Ping Huang , Brian Kane , Moon Hwan Kim , Michael Pack , Amy L. Tsuhako , Wei Xu , Cristiana A. Zaharia , Peiwen Zhou
IPC分类号: A01N43/54 , A61K31/505
CPC分类号: C07D405/04 , C07D403/04 , C07D413/04 , C07D417/04
摘要: A compound having Formula I: or a pharmaceutically acceptable salt thereof, wherein X, R, R and R are as defined in the specification; pharmaceutical compositions thereof; and methods of use thereof. The compounds of Formula I are inhibitors of Casein kinase II (CK2) pathways.
摘要翻译: 具有式I的化合物或其药学上可接受的盐,其中X,R,R和R如说明书中所定义; 其药物组合物; 及其使用方法。 式I的化合物是酪蛋白激酶II(CK2)途径的抑制剂。
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公开(公告)号:US20100144770A1
公开(公告)日:2010-06-10
申请号:US12597271
申请日:2008-04-24
申请人: Elena S. Koltun , Patrick Kearney , Naing Aay , Arlyn Arcalas , Wai Ki Vicky Chan , Jeffry Kimo Curtis , Hongwang Du , Ping Huang , Brian Kane , Moon Hwan Kim , Michael Pack , Amy L. Tsuhako , Wei Xu , Cristiana A. Zaharia , Peiwen Zhou
发明人: Elena S. Koltun , Patrick Kearney , Naing Aay , Arlyn Arcalas , Wai Ki Vicky Chan , Jeffry Kimo Curtis , Hongwang Du , Ping Huang , Brian Kane , Moon Hwan Kim , Michael Pack , Amy L. Tsuhako , Wei Xu , Cristiana A. Zaharia , Peiwen Zhou
IPC分类号: A61K31/506 , C07D239/36 , C07D401/10 , A61K31/4439 , A61P35/00
CPC分类号: C07D405/04 , C07D403/04 , C07D413/04 , C07D417/04
摘要: A compound having Formula I: or a pharmaceutically acceptable salt thereof, wherein X, R, R and R are as defined in the specification; pharmaceutical compositions thereof; and methods of use thereof. The compounds of Formula I are inhibitors of Casein kinase II (CK2) pathways.
摘要翻译: 具有式I的化合物或其药学上可接受的盐,其中X,R,R和R如说明书中所定义; 其药物组合物; 及其使用方法。 式I的化合物是酪蛋白激酶II(CK2)途径的抑制剂。
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公开(公告)号:US20130165440A1
公开(公告)日:2013-06-27
申请号:US13821435
申请日:2011-09-13
IPC分类号: C07D237/34 , C07D403/10 , C07D409/10 , C07D215/44 , C07D409/04 , C07D403/12 , C07D413/12 , C07D417/10 , C07D471/04
CPC分类号: C07D409/04 , C07D217/22 , C07D237/34 , C07D403/10 , C07D405/04 , C07D417/10 , C07D471/04
摘要: JAK1 inhibitors of structural formula (I), wherein Ar1, Ar2, Q, W, X, Y, and Z are defined in the specification, pharmaceutically acceptable salts thereof, compositions thereof, and use of the compounds and compositions for treating diseases. The invention also comprises use of the compounds in and for the manufacture of medicaments, particularly for treating diseases.
摘要翻译: 其中Ar1,Ar2,Q,W,X,Y和Z的结构式(I)的JAK1抑制剂在本说明书中定义,其药学上可接受的盐,其组合物,以及用于治疗疾病的化合物和组合物的用途。 本发明还包括在化合物中和用于制备药物中的用途,特别是用于治疗疾病。
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5.Benzoxazepines as inhibitors of PI3K/mTOR and methods of their use and manufacture 失效
标题翻译: 苯并西泮作为PI3K / mTOR的抑制剂及其使用和制造方法公开(公告)号:US08648066B2
公开(公告)日:2014-02-11
申请号:US12784254
申请日:2010-05-20
申请人: Neel Kumar Anand , Charles M. Blazey , Owen Joseph Bowles , Chris Allen Buhr , Joerg Bussenius , Jeffry Kimo Curtis , Steven Charles DeFina , Larisa Dubenko , Jason R. Harris , Eileen E. Jackson-Ugueto , Anagha Joshi , Angie Inyoung Kim , Amy Lew Tsuhako , Sunghoon Ma , Jean-Claire Limun Manalo , Stephanie Ng , Csaba J. Peto , Kenneth D. Rice , Tsze H. Tsang , Cristiana A. Zaharia
发明人: Neel Kumar Anand , Charles M. Blazey , Owen Joseph Bowles , Chris Allen Buhr , Joerg Bussenius , Jeffry Kimo Curtis , Steven Charles DeFina , Larisa Dubenko , Jason R. Harris , Eileen E. Jackson-Ugueto , Anagha Joshi , Angie Inyoung Kim , Amy Lew Tsuhako , Sunghoon Ma , Jean-Claire Limun Manalo , Stephanie Ng , Csaba J. Peto , Kenneth D. Rice , Tsze H. Tsang , Cristiana A. Zaharia
IPC分类号: A61P35/00 , A61K31/553 , C07D267/14
CPC分类号: C07D413/14 , C07D413/04 , C07D417/14 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/08 , C07D495/04 , C07D498/04 , C07D513/04 , C07D519/00
摘要: The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.
摘要翻译: 本发明涉及式I化合物及其药学上可接受的盐或溶剂合物,以及制备和使用该化合物的方法。
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6.Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture 失效
标题翻译: 苯并西泮作为PI3K / mTOR的抑制剂及其使用和制造方法公开(公告)号:US20100298290A1
公开(公告)日:2010-11-25
申请号:US12784254
申请日:2010-05-20
申请人: Neel Kumar Anand , Charles M. Blazey , Owen Joseph Bowles , Chris Allen Buhr , Joerg Bussenius , Jeffry Kimo Curtis , Steven Charles DeFina , Larisa Dubenko , Jason R. Harris , Eileen E. Jackson-Ugueto , Anagha Joshi , Angie Inyoung Kim , Amy Lew Tsuhako , Sunghoon Ma , Jean-Claire Limun Manalo , Stephanie Ng , Csaba J. Peto , Kenneth D. Rice , Tsze H. Tsang , Cristiana A. Zaharia
发明人: Neel Kumar Anand , Charles M. Blazey , Owen Joseph Bowles , Chris Allen Buhr , Joerg Bussenius , Jeffry Kimo Curtis , Steven Charles DeFina , Larisa Dubenko , Jason R. Harris , Eileen E. Jackson-Ugueto , Anagha Joshi , Angie Inyoung Kim , Amy Lew Tsuhako , Sunghoon Ma , Jean-Claire Limun Manalo , Stephanie Ng , Csaba J. Peto , Kenneth D. Rice , Tsze H. Tsang , Cristiana A. Zaharia
IPC分类号: A61K31/553 , C07D413/14 , A61P35/00 , A61P35/04
CPC分类号: C07D413/14 , C07D413/04 , C07D417/14 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/08 , C07D495/04 , C07D498/04 , C07D513/04 , C07D519/00
摘要: The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.
摘要翻译: 本发明涉及式I化合物及其药学上可接受的盐或溶剂合物,以及制备和使用该化合物的方法。
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公开(公告)号:US20120264737A1
公开(公告)日:2012-10-18
申请号:US13415660
申请日:2012-03-08
申请人: Johan D. Oslob , Robert S. McDowell , Russell Johnson , Hanbiao Yang , Marc Evanchik , Cristiana A. Zaharia , Haiying Cai , Lily W. Hu
发明人: Johan D. Oslob , Robert S. McDowell , Russell Johnson , Hanbiao Yang , Marc Evanchik , Cristiana A. Zaharia , Haiying Cai , Lily W. Hu
IPC分类号: A61K31/454 , C07D471/04 , A61K31/4545 , A61P35/00 , C07D401/12 , A61K31/55 , C07D487/04 , A61P31/12 , C07D491/052 , A61K31/5377
CPC分类号: C07D471/04 , A61K31/4525 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/55 , A61K31/7056 , A61K38/212 , A61K45/06 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/10 , C07D405/12 , C07D405/14 , C07D413/10 , C07D413/14 , C07D487/04 , C07D491/048 , C07D491/052 , C07D491/10 , C07D491/107 , C07D513/04 , A61K2300/00
摘要: Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.
摘要翻译: 提供了脂肪酸合成调节剂的化合物。 该化合物可用于治疗以调节功能和/或脂肪酸合成酶途径为特征的脂肪酸合酶功能失调的病症。 提供了用于治疗诸如丙型肝炎感染,癌症和代谢紊乱等病毒感染的疾病的方法。
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公开(公告)号:US08871790B2
公开(公告)日:2014-10-28
申请号:US13415660
申请日:2012-03-08
申请人: Johan D. Oslob , Robert S. McDowell , Russell Johnson , Hanbiao Yang , Marc Evanchik , Cristiana A. Zaharia , Haiying Cai , Lily W. Hu
发明人: Johan D. Oslob , Robert S. McDowell , Russell Johnson , Hanbiao Yang , Marc Evanchik , Cristiana A. Zaharia , Haiying Cai , Lily W. Hu
IPC分类号: A61K31/445 , C07D401/04
CPC分类号: C07D471/04 , A61K31/4525 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/55 , A61K31/7056 , A61K38/212 , A61K45/06 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/10 , C07D405/12 , C07D405/14 , C07D413/10 , C07D413/14 , C07D487/04 , C07D491/048 , C07D491/052 , C07D491/10 , C07D491/107 , C07D513/04 , A61K2300/00
摘要: Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.
摘要翻译: 提供了脂肪酸合成调节剂的化合物。 该化合物可用于治疗以调节功能和/或脂肪酸合成酶途径为特征的脂肪酸合酶功能失调的病症。 提供了用于治疗诸如丙型肝炎感染,癌症和代谢紊乱等病毒感染的疾病的方法。
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