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公开(公告)号:US20090247559A1
公开(公告)日:2009-10-01
申请号:US12341210
申请日:2008-12-22
申请人: S. David Brown , Hongwang Du , Maurizio Franzini , Adam Antoni Galan , Ping Huang , Patrick Kearney , Moon Hwan Kim , Elena S. Koltun , Steven James Richards , Amy L. Tsuhako , Cristiana A. Zaharia
发明人: S. David Brown , Hongwang Du , Maurizio Franzini , Adam Antoni Galan , Ping Huang , Patrick Kearney , Moon Hwan Kim , Elena S. Koltun , Steven James Richards , Amy L. Tsuhako , Cristiana A. Zaharia
IPC分类号: A61K31/519 , C07D487/04 , A61P35/00
CPC分类号: C07D491/04
摘要: A compound according to formula I: or a pharmaceutically acceptable salt thereof; wherein R1, R2, R3a, R3b, R3c and R3d are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof.
摘要翻译: 根据式I的化合物或其药学上可接受的盐; 其中R1,R2,R3a,R3b,R3c和R3d如说明书中所定义,其药物组合物及其使用方法。
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公开(公告)号:US08324231B2
公开(公告)日:2012-12-04
申请号:US12597271
申请日:2008-04-24
申请人: Elena S. Koltun , Patrick Kearney , Naing Aay , Arlyn Arcalas , Wai Ki Vicky Chan , Jeffry Kimo Curtis , Hongwang Du , Ping Huang , Brian Kane , Moon Hwan Kim , Michael Pack , Amy L. Tsuhako , Wei Xu , Cristiana A. Zaharia , Peiwen Zhou
发明人: Elena S. Koltun , Patrick Kearney , Naing Aay , Arlyn Arcalas , Wai Ki Vicky Chan , Jeffry Kimo Curtis , Hongwang Du , Ping Huang , Brian Kane , Moon Hwan Kim , Michael Pack , Amy L. Tsuhako , Wei Xu , Cristiana A. Zaharia , Peiwen Zhou
IPC分类号: A01N43/54 , A61K31/505
CPC分类号: C07D405/04 , C07D403/04 , C07D413/04 , C07D417/04
摘要: A compound having Formula I: or a pharmaceutically acceptable salt thereof, wherein X, R, R and R are as defined in the specification; pharmaceutical compositions thereof; and methods of use thereof. The compounds of Formula I are inhibitors of Casein kinase II (CK2) pathways.
摘要翻译: 具有式I的化合物或其药学上可接受的盐,其中X,R,R和R如说明书中所定义; 其药物组合物; 及其使用方法。 式I的化合物是酪蛋白激酶II(CK2)途径的抑制剂。
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公开(公告)号:US20100144770A1
公开(公告)日:2010-06-10
申请号:US12597271
申请日:2008-04-24
申请人: Elena S. Koltun , Patrick Kearney , Naing Aay , Arlyn Arcalas , Wai Ki Vicky Chan , Jeffry Kimo Curtis , Hongwang Du , Ping Huang , Brian Kane , Moon Hwan Kim , Michael Pack , Amy L. Tsuhako , Wei Xu , Cristiana A. Zaharia , Peiwen Zhou
发明人: Elena S. Koltun , Patrick Kearney , Naing Aay , Arlyn Arcalas , Wai Ki Vicky Chan , Jeffry Kimo Curtis , Hongwang Du , Ping Huang , Brian Kane , Moon Hwan Kim , Michael Pack , Amy L. Tsuhako , Wei Xu , Cristiana A. Zaharia , Peiwen Zhou
IPC分类号: A61K31/506 , C07D239/36 , C07D401/10 , A61K31/4439 , A61P35/00
CPC分类号: C07D405/04 , C07D403/04 , C07D413/04 , C07D417/04
摘要: A compound having Formula I: or a pharmaceutically acceptable salt thereof, wherein X, R, R and R are as defined in the specification; pharmaceutical compositions thereof; and methods of use thereof. The compounds of Formula I are inhibitors of Casein kinase II (CK2) pathways.
摘要翻译: 具有式I的化合物或其药学上可接受的盐,其中X,R,R和R如说明书中所定义; 其药物组合物; 及其使用方法。 式I的化合物是酪蛋白激酶II(CK2)途径的抑制剂。
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公开(公告)号:US20100135954A1
公开(公告)日:2010-06-03
申请号:US12597275
申请日:2008-04-25
申请人: Amy L. Tsuhako , Naing Aay , S. David Brown , Wai Ki Vicky Chan , Hongwang Du , Ping Huang , Brian Kane , Patrick Kearney , Moon Hwan Kim , Elena S. Koltun , Michael Pack , Wei Xu , Peiwen Zhou
发明人: Amy L. Tsuhako , Naing Aay , S. David Brown , Wai Ki Vicky Chan , Hongwang Du , Ping Huang , Brian Kane , Patrick Kearney , Moon Hwan Kim , Elena S. Koltun , Michael Pack , Wei Xu , Peiwen Zhou
IPC分类号: A61K38/20 , A61K38/21 , A61K31/567 , A61K31/5377 , A61K31/496 , A61K31/506 , C07D413/02 , C07D403/10 , C07D401/10 , A61P35/00
CPC分类号: C07D213/64 , C07D239/36 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/04 , C07D409/12 , C07D413/04
摘要: A compound having Formula I or II (Formula I) or (Formula II), or a pharmaceutically acceptable salt thereof, wherein X, Z, R1, R2, R11 and R12 are as defined in the specification; pharmaceutical compositions thereof; and methods of use thereof.
摘要翻译: 具有式I或II(式I)或(式II)的化合物或其药学上可接受的盐,其中X,Z,R 1,R 2,R 11和R 12如说明书中所定义; 其药物组合物; 及其使用方法。
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公开(公告)号:US08242129B2
公开(公告)日:2012-08-14
申请号:US12597275
申请日:2008-04-25
申请人: Amy L. Tsuhako , Naing Aay , S. David Brown , Wai Ki Vicky Chan , Hongwang Du , Ping Huang , Brian Kane , Patrick Kearney , Moon Hwan Kim , Elena S. Koltun , Michael Pack , Wei Xu , Peiwen Zhou
发明人: Amy L. Tsuhako , Naing Aay , S. David Brown , Wai Ki Vicky Chan , Hongwang Du , Ping Huang , Brian Kane , Patrick Kearney , Moon Hwan Kim , Elena S. Koltun , Michael Pack , Wei Xu , Peiwen Zhou
IPC分类号: A61K31/505
CPC分类号: C07D213/64 , C07D239/36 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/04 , C07D409/12 , C07D413/04
摘要: A compound having Formula I or II (Formula I) or (Formula II), or a pharmaceutically acceptable salt thereof, wherein X, Z, R1, R2, R11 and R12 are as defined in the specification; pharmaceutical compositions thereof; and methods of use thereof.
摘要翻译: 具有式I或II(式I)或(式II)的化合物或其药学上可接受的盐,其中X,Z,R 1,R 2,R 11和R 12如说明书中所定义; 其药物组合物; 及其使用方法。
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公开(公告)号:US20090215803A1
公开(公告)日:2009-08-27
申请号:US12083749
申请日:2006-10-23
申请人: Kenneth D. Rice , Neel Kumar Anand , Arlyn Arcalas , Charles M. Blazey , Joerg Bussenius , Wai Ki Vickey Chan , Hongwang Du , Sergey Epshteyn , Mohamed Abdulkader Ibrahim , Patrick Kearney , Abigail R. Kennedy , Moon Hwan Kim , Jean-Claire Limun Manalo , Csaba J. Peto , Tsze H. Tsang , Amy Lew Tsuhako , Peiwen Zhou , Elena S. Koltun
发明人: Kenneth D. Rice , Neel Kumar Anand , Arlyn Arcalas , Charles M. Blazey , Joerg Bussenius , Wai Ki Vickey Chan , Hongwang Du , Sergey Epshteyn , Mohamed Abdulkader Ibrahim , Patrick Kearney , Abigail R. Kennedy , Moon Hwan Kim , Jean-Claire Limun Manalo , Csaba J. Peto , Tsze H. Tsang , Amy Lew Tsuhako , Peiwen Zhou , Elena S. Koltun
IPC分类号: A61K31/513 , C07D403/02 , C12N9/99 , A61P35/00
CPC分类号: C07D487/04
摘要: A compound having Formula (I) or a pharmaceutically acceptable salt thereof, wherein X, R1 and R2 are defined in the specification; pharmaceutical compositions thereof; and methods of use thereof.
摘要翻译: 具有式(I)的化合物或其药学上可接受的盐,其中X,R 1和R 2在说明书中定义; 其药物组合物; 及其使用方法。
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公开(公告)号:US08101625B2
公开(公告)日:2012-01-24
申请号:US12083749
申请日:2006-10-23
申请人: Kenneth D. Rice , Neel Kumar Anand , Arlyn Arcalas , Charles M. Blazey , Joerg Bussenius , Wai Ki Vicky Chan , Hongwang Du , Sergey Epshteyn , Mohamed Abdulkader Ibrahim , Patrick Kearney , Abigail R. Kennedy , Moon Hwan Kim , Jean-Claire Limun Manalo , Csaba J. Peto , Tsze H. Tsang , Amy Lew Tsuhako , Peiwen Zhou , Elena S. Koltun
发明人: Kenneth D. Rice , Neel Kumar Anand , Arlyn Arcalas , Charles M. Blazey , Joerg Bussenius , Wai Ki Vicky Chan , Hongwang Du , Sergey Epshteyn , Mohamed Abdulkader Ibrahim , Patrick Kearney , Abigail R. Kennedy , Moon Hwan Kim , Jean-Claire Limun Manalo , Csaba J. Peto , Tsze H. Tsang , Amy Lew Tsuhako , Peiwen Zhou , Elena S. Koltun
IPC分类号: A61K31/505 , C07D239/02
CPC分类号: C07D487/04
摘要: A compound having Formula (I) or a pharmaceutically acceptable salt thereof, wherein X, R1 and R2 are defined in the specification; pharmaceutical compositions thereof; and methods of use thereof.
摘要翻译: 具有式(I)的化合物或其药学上可接受的盐,其中X,R 1和R 2在说明书中定义; 其药物组合物; 及其使用方法。
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8.4-aryl-2-amino-pyrimidines or 4-aryl-2-aminoalkyl-pyrimidines as JAK-2 modulators and methods of use 失效
标题翻译: 4-芳基-2-氨基 - 嘧啶或4-芳基-2-氨基烷基 - 嘧啶作为JAK-2调节剂和使用方法公开(公告)号:US08440663B2
公开(公告)日:2013-05-14
申请号:US11992224
申请日:2007-01-30
申请人: Grace Mann , Naing Aay , Arlyn Arcalas , S. David Brown , Wai Ki Vicky Chan , Jeff Chen , Hongwang Du , Sergey Epshteyn , Timothy Patrick Forsyth , Adam A. Galan , Tai Phat Huynh , Mohamed Abdulkader Ibrahim , Henry William Beecroft Johnson , Brian Kane , Patrick Kearney , Byung Gyu Kim , Elena S. Koltun , James W. Leahy , Matthew Sangyup Lee , Gary L. Lewis , Lisa E. Meyr , Robin Tammie Noguchi , Michael Pack , Brian Hugh Ridgway , Xian Shi , John Woolfrey , Peiwen Zhou
发明人: Grace Mann , Naing Aay , Arlyn Arcalas , S. David Brown , Wai Ki Vicky Chan , Jeff Chen , Hongwang Du , Sergey Epshteyn , Timothy Patrick Forsyth , Adam A. Galan , Tai Phat Huynh , Mohamed Abdulkader Ibrahim , Henry William Beecroft Johnson , Brian Kane , Patrick Kearney , Byung Gyu Kim , Elena S. Koltun , James W. Leahy , Matthew Sangyup Lee , Gary L. Lewis , Lisa E. Meyr , Robin Tammie Noguchi , Michael Pack , Brian Hugh Ridgway , Xian Shi , John Woolfrey , Peiwen Zhou
IPC分类号: A61K31/535 , C07D239/24 , C07D401/10 , C07D413/10
CPC分类号: C07D239/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/12 , C07D453/02 , C07D487/04
摘要: This invention relates to certain pyrimidine derivative inhibitors of JAK-2, having Formula (I): wherein D, E, L, Z, R1, R2, R25, and n1 are as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof.
摘要翻译: 本发明涉及具有式(I)的JAK-2的某些嘧啶衍生物抑制剂:其中D,E,L,Z,R 1,R 2,R 25和n 1如说明书中所定义,其药学上可接受的盐,药物组合物 及其使用方法。
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9.4-Aryl-2-Amino-Pyrimidnes or 4-Aryl-2-Aminoalkyl-Pyrimidines as Jak-2 Modulators and Methods of Use 失效
标题翻译: 4-芳基-2-氨基 - 嘧啶或4-芳基-2-氨基烷基 - 嘧啶作为Jak-2调节剂和使用方法公开(公告)号:US20090298830A1
公开(公告)日:2009-12-03
申请号:US11992224
申请日:2007-01-30
申请人: Grace Mann , Naing Aay , Arlyn Arcalas , S. David Brown , Wai Ki Vicky Chan , Jeff Chen , Hongwang Du , Sergey Epshteyn , Timothy Patrick Forsyth , Adam A. Galan , Tai Phat Huynh , Mohamed Abdulkader Ibrahim , Henry William Beecroft Johnson , Brian Kane , Patrick Kearney , Byung Gyu Kim , Elena S. Koltun , James W. Leahy , Matthew Sangyup Lee , Gary L. Lewis , Lisa E. Meyr , Robin Tammie Noguchi , Michael Pack , Brian Hugh Ridgway , Xian Shi , John Woolfrey , Peiwen Zhou
发明人: Grace Mann , Naing Aay , Arlyn Arcalas , S. David Brown , Wai Ki Vicky Chan , Jeff Chen , Hongwang Du , Sergey Epshteyn , Timothy Patrick Forsyth , Adam A. Galan , Tai Phat Huynh , Mohamed Abdulkader Ibrahim , Henry William Beecroft Johnson , Brian Kane , Patrick Kearney , Byung Gyu Kim , Elena S. Koltun , James W. Leahy , Matthew Sangyup Lee , Gary L. Lewis , Lisa E. Meyr , Robin Tammie Noguchi , Michael Pack , Brian Hugh Ridgway , Xian Shi , John Woolfrey , Peiwen Zhou
IPC分类号: A61K31/5377 , C07D413/14 , A61P7/00
CPC分类号: C07D239/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/12 , C07D453/02 , C07D487/04
摘要: This invention relates to certain pyrimidine derivative inhibitors of JAK-2, having Formula (I): wherein D, E, L, Z, R1, R2, R25, and n1 are as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof.
摘要翻译: 本发明涉及具有式(I)的JAK-2的某些嘧啶衍生物抑制剂:其中D,E,L,Z,R 1,R 2,R 25和n 1如说明书中所定义,其药学上可接受的盐,药物组合物 及其使用方法。
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公开(公告)号:US20090042918A1
公开(公告)日:2009-02-12
申请号:US12088474
申请日:2006-10-05
申请人: Patrick Kearney , S. David Brown , Elena S. Koltun
发明人: Patrick Kearney , S. David Brown , Elena S. Koltun
IPC分类号: A61K31/41 , A61P35/00 , C07D409/12 , C07D257/04 , C07D417/12 , C07D413/12 , A61K31/4439 , C07D401/12 , C07D333/38 , A61K31/506 , A61K31/454 , A61K31/422
CPC分类号: C07D409/12 , C07C233/63 , C07C2601/08 , C07D213/81 , C07D257/04 , C07D307/68 , C07D307/93 , C07D333/38 , C07D333/70 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要: Compounds of formula (I), useful for inhibiting PIM-I and/or PIM-3: and pharmaceutically acceptable salts thereof, wherein Y, Z, R1, R3, Q, X and R4 are as defined above. Pharmaceutical compositions and methods of treating diseases and conditions, such as cancer, are also disclosed.
摘要翻译: 可用于抑制PIM-1和/或PIM-3的式(I)化合物及其药学上可接受的盐,其中Y,Z,R 1,R 3,Q,X和R 4如上所定义。 还公开了治疗疾病和病症如癌症的药物组合物和方法。
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