-
公开(公告)号：US20190382389A1
公开(公告)日：2019-12-19
申请号：US16247843
申请日：2019-01-15
发明人： James Robert Zeller , Sripathy Venkatraman , Elisabeth C.A. Brot , Subashree Iyer , Michael Hall
IPC分类号： C07D407/06 , C07D405/06
摘要： Methods of preparation and purification of a compound of Formula I, intermediates thereof, a polymorph thereof, and related compounds are disclosed. Formulations and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed.
-
公开(公告)号：US09708303B2
公开(公告)日：2017-07-18
申请号：US14747745
申请日：2015-06-23
发明人： James Robert Zeller , Sripathy Venkatraman , Elisabeth C. A. Brot , Subashree Iyer , Michael Hall
IPC分类号： C07D405/06 , C07D407/06
CPC分类号： C07D407/06 , C07B2200/13 , C07D405/06
摘要： Methods of preparation and purification of a compound of Formula I, intermediates thereof, a polymorph thereof, and related compounds are disclosed. Formulations and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed.
-
公开(公告)号：US20160090361A1
公开(公告)日：2016-03-31
申请号：US14866085
申请日：2015-09-25
发明人： Scott Tweedie , Sripathy Venkatraman , Shuhong Liu , James Zeller , Elisabeth Brot , Michael Hamlin , Mary Newman , Mark McLaws , John Rosenberg , David Lathbury
IPC分类号： C07D217/04 , B01J19/24
CPC分类号： C07D217/04 , B01J19/24 , B01J19/242 , B01J19/243 , B01J2219/00099 , B01J2219/0286 , B01J2219/24
摘要： The present invention is related to a two-step carboxylation reaction of an aryl group using continuous flow reaction conditions. This process permits large scale synthesis of useful reaction products in high yield.
摘要翻译： 本发明涉及使用连续流动反应条件进行芳基的两步羧化反应。 该方法可以高产率大规模合成有用的反应产物。
-
公开(公告)号：US10273212B2
公开(公告)日：2019-04-30
申请号：US15635632
申请日：2017-06-28
IPC分类号： B01J19/24 , C07D217/04
摘要： The present invention is related to a two-step carboxylation reaction of an aryl group using continuous flow reaction conditions. This process permits large scale synthesis of useful reaction products in high yield.
-
公开(公告)号：US10214517B2
公开(公告)日：2019-02-26
申请号：US15621141
申请日：2017-06-13
发明人： James Robert Zeller , Sripathy Venkatraman , Elisabeth C. A. Brot , Subashree Iyer , Michael Hall
IPC分类号： C07D405/06 , C07D407/06
摘要： Methods of preparation and purification of a compound of Formula I, intermediates thereof, a polymorph thereof, and related compounds are disclosed. Formulations and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed.
-
公开(公告)号：US09085553B2
公开(公告)日：2015-07-21
申请号：US13950807
申请日：2013-07-25
发明人： James Robert Zeller , Sripathy Venkatraman , Elisabeth C. A. Brot , Subashree Iyer , Michael Hall
IPC分类号： C07D405/06
CPC分类号： C07D407/06 , C07B2200/13 , C07D405/06
摘要： Methods of preparation and purification of a compound of Formula I, intermediates thereof, a polymorph thereof, and related compounds are disclosed. Formulations and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed.
摘要翻译： 公开了制备和纯化式I化合物的方法，其中间体，其多晶型物和相关化合物。 还公开了其在治疗LFA-1介导的疾病中的制剂及其用途。
-
公开(公告)号：US20140031387A1
公开(公告)日：2014-01-30
申请号：US13950807
申请日：2013-07-25
发明人： James Robert Zeller , Sripathy Venkatraman , Elisabeth C. A. Brot , Subashree Iyer , Michael Hall
IPC分类号： C07D405/06
CPC分类号： C07D407/06 , C07B2200/13 , C07D405/06
摘要： Methods of preparation and purification of a compound of Formula I, intermediates thereof, a polymorph thereof, and related compounds are disclosed. Formulations and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed.
摘要翻译： 公开了制备和纯化式I化合物的方法，其中间体，其多晶型物和相关化合物。 还公开了其在治疗LFA-1介导的疾病中的制剂及其用途。
-
公开(公告)号：US09725413B2
公开(公告)日：2017-08-08
申请号：US14866085
申请日：2015-09-25
IPC分类号： C07D217/04 , C07B45/04 , B01J19/24
CPC分类号： C07D217/04 , B01J19/24 , B01J19/242 , B01J19/243 , B01J2219/00099 , B01J2219/0286 , B01J2219/24
摘要： The present invention is related to a two-step carboxylation reaction of an aryl group using continuous flow reaction conditions. This process permits large scale synthesis of useful reaction products in high yield.
-
公开(公告)号：US20190300485A1
公开(公告)日：2019-10-03
申请号：US16378868
申请日：2019-04-09
IPC分类号： C07D217/04 , B01J19/24
摘要： The present invention is related to a two-step carboxylation reaction of an aryl group using continuous flow reaction conditions. This process permits large scale synthesis of useful reaction products in high yield.
-
公开(公告)号：US20180118689A1
公开(公告)日：2018-05-03
申请号：US15635632
申请日：2017-06-28
IPC分类号： C07D217/04 , B01J19/24
CPC分类号： C07D217/04 , B01J19/24 , B01J19/242 , B01J19/243 , B01J2219/00099 , B01J2219/0286 , B01J2219/24
摘要： The present invention is related to a two-step carboxylation reaction of an aryl group using continuous flow reaction conditions. This process permits large scale synthesis of useful reaction products in high yield.
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.015 秒)
