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公开(公告)号：US20210333295A1
公开(公告)日：2021-10-28
申请号：US17294151
申请日：2019-11-15
发明人： Toshiki KAWABE , Yukio ODA
IPC分类号： G01N33/86
摘要： Excellent analysis of a coagulation characteristic of a blood sample is implemented. A method for analyzing a coagulation characteristic of a blood specimen according to the present invention includes: acquiring data for a coagulation reaction curve indicating a coagulation reaction amount of a mixed solution containing a blood sample and a reagent with respect to reaction time; calculating data for a differential curve obtained by differentiating the coagulation reaction curve; calculating information related to a center-of-gravity point of the differential curve; and evaluating the coagulation characteristic of the blood sample using the information related to the center-of-gravity point.
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公开(公告)号：US20220146537A1
公开(公告)日：2022-05-12
申请号：US17427000
申请日：2020-01-31
发明人： Toshiki KAWABE , Yukio ODA , Midori SHIMA , Keiji NOGAMI , Kenichi OGIWARA
摘要： To provide a method for analyzing coagulation characteristics of a blood specimen. To provide a method for analyzing a blood specimen, including: acquiring a waveform related to a coagulation rate or coagulation acceleration of a sample obtained by mixing a subject blood specimen with a reagent for measuring coagulation time; extracting multiple parameters characterizing the waveform related to a coagulation rate or a coagulation acceleration; and determining an activity level or activity abnormality of a coagulation factor in the subject blood specimen on the basis of the multiple parameters.
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公开(公告)号：US20220326262A1
公开(公告)日：2022-10-13
申请号：US17606274
申请日：2020-04-23
发明人： Toshiki KAWABE , Yukio ODA , Mari EMMI , Midori SHIMA , Keiji NOGAMI , Kenichi OGIWARA , Naruto SHIMONISHI
摘要： Provided is a method by which a titer of a coagulation factor inhibitor can be measured simply and in a short time. The present invention relates to a method for measuring a titer of a coagulation factor inhibitor. The method includes: preparing a mixed specimen containing a subject blood specimen and a normal blood specimen; heating the mixed specimen and acquiring a coagulation reaction curve for the heated mixed specimen; acquiring a coagulation reaction curve for the mixed specimen that has not been heated; calculating a parameter related to the coagulation reaction curve of the mixed specimen that has not been heated as a first parameter; calculating a parameter related to the coagulation reaction curve of the heated mixed specimen as a second parameter; and calculating a titer of a coagulation factor inhibitor in the subject blood specimen on the basis of the ratio or the difference between the first parameter and the second parameter.
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公开(公告)号：US20220373565A1
公开(公告)日：2022-11-24
申请号：US17620436
申请日：2020-06-19
发明人： Toshiki KAWABE , Yukio ODA , Midori SHIMA , Keiji NOGAMI , Kenichi OGIWARA , Naruto SHIMONISHI
摘要： An APTT prolongation factor estimation system includes one or more facilities each including an analyzer which measures a blood coagulation reaction of a subject blood specimen, a database which stores data on a blood coagulation reaction and APTT prolongation factor of blood specimens, and a computer which estimates an APTT prolongation factor of the subject blood specimen based on the data on the blood coagulation reaction from the analyzer and the data stored in the database. The facilities each further includes a data transmission unit which transmits, to the computer, the data on the blood coagulation reaction of the subject blood specimen obtained by the analyzer, and a data reception unit which receives a result of the estimation of the APTT prolongation factor, which is obtained by the computer, regarding the subject blood specimen measured by each of the analyzers.
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