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公开(公告)号：US11964004B2
公开(公告)日：2024-04-23
申请号：US17709403
申请日：2022-03-30
Applicant: SHENZHEN BAY LABORATORY
Inventor： Xinli Henry Lin
CPC classification number: A61K38/484 , A61P7/02
Abstract: The present disclosure provides is a short in vivo half-life and in vivo unstable recombinant microplasmin, wherein the recombinant microplasmin can be a mutant type and wild type and is expressed in a bacteria host, can be purified, or can be refolded and purified in case expressed as an insoluble inclusion body, producing an active thrombolytic agent. The present disclosure also provides the pharmaceutical composition comprising the recombinant microplasmin and method of treating thromboembolism related diseases including the administration of the pharmaceutical composition.
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