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    Compositions and methods for detecting microorganisms
    2.
    发明授权
    Compositions and methods for detecting microorganisms 有权

    公开(公告)号：US10538771B2

    公开(公告)日：2020-01-21

    申请号：US16118596

    申请日：2018-08-31

    申请人： SomaLogic, Inc.

    发明人： Urs A. Ochsner ,  Nebojsa Janjic

    IPC分类号： C07H21/02 ,  C07H21/04 ,  C12N15/115 ,  G01N33/53 ,  G01N33/569 ,  C12N15/10 ,  C12Q1/14

    摘要： Described herein are compositions and methods for detecting the presence or absence of a microorganism in a sample comprising contacting the sample with an aptamer capable of binding to a cell-surface protein of the microorganism to form a complex, contacting the mixture with a second aptamer capable of binding to the first cell-surface protein or a second cell-surface protein of the microorganism; and performing an assay to detect the second aptamer, wherein detecting the second aptamer indicates that the microorganism is present in the sample, and wherein not detecting the second aptamer indicates that the microorganism is absent from the sample.

    Tuberculosis Biomarkers and Uses Thereof
    5.
    发明申请
    Tuberculosis Biomarkers and Uses Thereof 审中-公开
    结核病生物标志物及其用途

    公开(公告)号：US20140155411A1

    公开(公告)日：2014-06-05

    申请号：US13862177

    申请日：2013-04-12

    申请人： SomaLogic, Inc.

    发明人： Urs Ochsner ,  David G. Sterling ,  Nebojsa Janjic

    IPC分类号： G01N33/569 ,  A61K31/496

    CPC分类号： G01N33/6893 ,  A61K31/496 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/5695 ,  G01N2570/00 ,  G01N2800/52 ,  G01N2800/60

    摘要： The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection, treatment and diagnosis of tuberculosis (TB). In one aspect, the present application includes the identification of biomarkers that can be used alone or in various combinations for the detection of TB, including those set forth in Tables 1, 2, 4, 5, and 8 to 12. In another aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose or prognose TB or follow treatment response. In another aspect, methods are provided for diagnosing TB in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Tables 1, 2, 4, 5, and 8 to 12, wherein the individual is classified as having TB, or the likelihood of the individual having TB is determined, based on the at least one biomarker value.

    摘要翻译： 本申请包括用于结核病（TB）的检测，治疗和诊断的生物标志物，方法，装置，试剂，系统和试剂盒。 在一个方面，本申请包括可以单独使用或以各种组合用于检测TB的生物标志物的鉴定，包括表1,2,4,5和8所示的那些。在另一方面， 该应用提供了可以单独使用或以各种组合使用以诊断或预测结核病或遵循治疗反应的生物标志物。 在另一方面，提供了用于诊断个体中的结核病的方法，其中所述方法包括在来自个体的生物样品中检测至少一种对应于选自表1中提供的生物标志物组的至少一种生物标志物的生物标记值， 2，4，5和8至12，其中基于至少一种生物标记值，将个体分类为具有TB或确定具有TB的个体的可能性。

    Compositions and Methods for Detecting Microorganisms
    9.
    发明申请
    Compositions and Methods for Detecting Microorganisms 审中-公开

    公开(公告)号：US20180371462A1

    公开(公告)日：2018-12-27

    申请号：US16118596

    申请日：2018-08-31

    申请人： SomaLogic, Inc.

    发明人： Urs A. Ochsner ,  Nebojsa Janjic

    IPC分类号： C12N15/115 ,  C12Q1/14 ,  G01N33/53 ,  G01N33/569 ,  C12N15/10

    摘要： Described herein are compositions and methods for detecting the presence or absence of a microorganism in a sample comprising contacting the sample with an aptamer capable of binding to a cell-surface protein of the microorganism to form a complex, contacting the mixture with a second aptamer capable of binding to the first cell-surface protein or a second cell-surface protein of the microorganism; and performing an assay to detect the second aptamer, wherein detecting the second aptamer indicates that the microorganism is present in the sample, and wherein not detecting the second aptamer indicates that the microorganism is absent from the sample.