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1.发明公开公开(公告)号：US20240118272A1
公开(公告)日：2024-04-11
申请号：US18469093
申请日：2023-09-18
Applicant: SYSMEX CORPORATION
Inventor： Eiya TAMADA , Masatoshi Yanagida , Kazuto Yamashita , Elnaz Nakhael , Mami Onishi , Maria Kiriyama
IPC: G01N33/543 , C07K14/705 , C07K16/28
CPC classification number: G01N33/54333 , C07K14/70596 , C07K16/2803 , C07K16/2896 , G01N2333/916 , G01N2496/00
Abstract: Disclosed is a method for measuring an activity of alkaline phosphatase contained in an extracellular vesicle in a sample, including acquiring an activity value of alkaline phosphatase contained in an extracellular vesicle in a sample using a calibrator, in which the calibrator contains a conjugate in which a polypeptide having alkaline phosphatase activity and a polypeptide including an amino acid sequence of a membrane protein present on a surface of the extracellular vesicle are covalently bound.
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公开(公告)号：US11112404B2
公开(公告)日：2021-09-07
申请号：US15951375
申请日：2018-04-12
Applicant: SYSMEX CORPORATION
Inventor： Kenji Akama , Toshihiro Watanabe , Masaya Okada , Kazuto Yamashita , Akshay Ganguly , Shigeki Iwanaga
IPC: G01N33/543 , C07K16/18 , G01N33/533 , G01N33/68 , G01N33/58
Abstract: Disclosed is a method for obtaining information of a test substance, the method including: forming a complex by causing a capture substance to bind to a test substance in a specimen; selectively collecting at least the complex from the specimen; immobilizing the complex collected from the specimen, onto a base plate; and obtaining information regarding a structure of the test substance from the complex immobilized on the base plate.
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公开(公告)号：US20210255191A1
公开(公告)日：2021-08-19
申请号：US17163993
申请日：2021-02-01
Applicant: Eisai R&D Management Co., Ltd. , SYSMEX CORPORATION
Inventor： Daiki HARA , Takafumi Motoki , Yuji Kazuta , Yoshihiko Norimine , Hiroyuki Amino , Masatoshi Suganuma , Shingo Fujiyama , Kazuto Yamashita , Masaya Okada , Yoichi Nishikawa , Shigeki Iwanaga
Abstract: Disclosed is: a fluorescent dye comprising a compound, a tautomer of the compound, or a salt of the compound or the tautomer; a labeled composite substance comprising the fluorescent dye and a composite substance which are bonded to each other; a composition containing the fluorescent dye or the labeled composite substance; and a method for acquiring information about a substance of interest by a super-resolution microscopy.
