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127 条记录 (耗时 0.029 秒)

    2-AMINOQUINOLINES
    1.
    发明申请
    2-AMINOQUINOLINES 失效
    2-氨基喹啉

    公开(公告)号：US20090233927A1

    公开(公告)日：2009-09-17

    申请号：US12398415

    申请日：2009-03-05

    申请人： Sabine Kolczewski ,  Claus Riemer ,  Olivier Roche ,  Lucinda Steward ,  Juergen Wichmann ,  Thomas Woltering

    发明人： Sabine Kolczewski ,  Claus Riemer ,  Olivier Roche ,  Lucinda Steward ,  Juergen Wichmann ,  Thomas Woltering

    IPC分类号： A61K31/47 ,  C07D215/38 ,  C07D413/02 ,  A61K31/5377 ,  A61P25/00

    CPC分类号： C07D405/12 ,  C07D215/38 ,  C07D491/08

    摘要： The present invention is concerned with 2-aminoquinoline derivatives of formula I wherein R1 and R2 are as described herein and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them, and methods for their manufacture. These compounds are 5-HT5A receptor antagonists, useful for the prevention and/or treatment of depression, anxiety disorders, schizophrenia, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, pain, memory disorders, dementia, disorders of eating behaviors, sexual dysfunction, sleep disorders, abuse of drugs, motor disorders such as Parkinson's disease, psychiatric disorders or gastrointestinal disorders.

    摘要翻译： 本发明涉及式I的2-氨基喹啉衍生物，其中R 1和R 2如本文所述及其药学上可接受的盐，含有它们的药物组合物及其制备方法。 这些化合物是可用于预防和/或治疗抑郁症，焦虑障碍，精神分裂症，恐慌症，广场恐惧症，社交恐惧症，强迫症，创伤后应激障碍，疼痛，记忆障碍，痴呆症， 饮食行为障碍，性功能障碍，睡眠障碍，药物滥用，运动障碍如帕金森病，精神病或胃肠道疾病。

    6-substituted benzoxazines
    3.
    发明授权
    6-substituted benzoxazines 失效
    6-取代的苯并恶嗪

    公开(公告)号：US08163740B2

    公开(公告)日：2012-04-24

    申请号：US12549745

    申请日：2009-08-28

    申请人： Sabine Kolczewski ,  Olivier Roche ,  Lucinda Steward ,  Juergen Wichmann ,  Thomas Woltering

    发明人： Sabine Kolczewski ,  Olivier Roche ,  Lucinda Steward ,  Juergen Wichmann ,  Thomas Woltering

    IPC分类号： C07D265/02 ,  C07D413/04 ,  A61K31/536

    CPC分类号： C07D265/18 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D451/02 ,  C07D498/08

    摘要： The present invention is concerned with 6-substituted benzoxazine derivatives of formula (I) wherein X, Y, R1 and R2 are as described herein, their manufacture, and pharmaceutical compositions containing them. The active compounds of the present invention are 5-HT5A receptor antagonists, useful in the prevention and/or treatment of depression, anxiety disorders, schizophrenia, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, pain, memory disorders, dementia, disorders of eating behaviors, sexual dysfunction, sleep disorders, abuse of drugs, motor disorders, Parkinson's disease, psychiatric disorders or gastrointestinal disorders.

    摘要翻译： 本发明涉及式（I）的6-取代苯并恶嗪衍生物，其中X，Y，R 1和R 2如本文所述，其制备和含有它们的药物组合物。 本发明的活性化合物是可用于预防和/或治疗抑郁症，焦虑障碍，精神分裂症，惊恐障碍，广场恐怖症，社交恐惧症，强迫症，强迫症，创伤后应激障碍，疼痛， 记忆障碍，痴呆，饮食行为障碍，性功能障碍，睡眠障碍，药物滥用，运动障碍，帕金森病，精神病或胃肠疾病。

    5-SUBSTITUTED BENZOXAZINES
    4.
    发明申请
    5-SUBSTITUTED BENZOXAZINES 失效
    5-取代苯并噻唑

    公开(公告)号：US20100063042A1

    公开(公告)日：2010-03-11

    申请号：US12549687

    申请日：2009-08-28

    申请人： Sabine Kolczewski ,  Olivier Roche ,  Lucinda Steward ,  Juergen Wichmann ,  Thomas Woltering

    发明人： Sabine Kolczewski ,  Olivier Roche ,  Lucinda Steward ,  Juergen Wichmann ,  Thomas Woltering

    IPC分类号： A61K31/536 ,  C07D265/18

    CPC分类号： C07D265/18

    摘要： The present invention is concerned with 5-substituted benzoxazine derivatives of formula (I) wherein X, R1 and R2 are as described herein, as well as their manufacture, pharmaceutical compositions containing them. Compounds of the present invention are 5-HT5A receptor antagonists, and are useful in the prevention and/or treatment of depression, anxiety disorders, schizophrenia, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, pain, memory disorders, dementia, disorders of eating behaviors, sexual dysfunction, sleep disorders, abuse of drugs, motor disorders such as Parkinson's disease, psychiatric disorders or gastrointestinal disorders.

    摘要翻译： 本发明涉及式（I）的5-取代苯并恶嗪衍生物，其中X，R 1和R 2如本文所述，以及它们的制备，含有它们的药物组合物。 本发明化合物是5-HT5A受体拮抗剂，可用于预防和/或治疗抑郁症，焦虑障碍，精神分裂症，恐慌症，广场恐惧症，社交恐惧症，强迫症，创伤后应激障碍，疼痛， 记忆障碍，痴呆，饮食行为障碍，性功能障碍，睡眠障碍，滥用药物，运动障碍如帕金森病，精神病或胃肠疾病。

    5-substituted benzoxazines
    6.
    发明授权
    5-substituted benzoxazines 失效
    5-取代的苯并恶嗪

    公开(公告)号：US08044047B2

    公开(公告)日：2011-10-25

    申请号：US12549687

    申请日：2009-08-28

    申请人： Sabine Kolczewski ,  Olivier Roche ,  Lucinda Steward ,  Juergen Wichmann ,  Thomas Woltering

    发明人： Sabine Kolczewski ,  Olivier Roche ,  Lucinda Steward ,  Juergen Wichmann ,  Thomas Woltering

    IPC分类号： C07D265/02 ,  C07D413/04 ,  A61K31/536

    CPC分类号： C07D265/18

    摘要： The present invention is concerned with 5-substituted benzoxazine derivatives of formula (I) wherein X, R1 and R2 are as described herein, as well as their manufacture, pharmaceutical compositions containing them. Compounds of the present invention are 5-HT5A receptor antagonists, and are useful in the prevention and/or treatment of depression, anxiety disorders, schizophrenia, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, pain, memory disorders, dementia, disorders of eating behaviors, sexual dysfunction, sleep disorders, abuse of drugs, motor disorders such as Parkinson's disease, psychiatric disorders or gastrointestinal disorders.

    摘要翻译： 本发明涉及式（I）的5-取代苯并恶嗪衍生物，其中X，R 1和R 2如本文所述，以及它们的制备，含有它们的药物组合物。 本发明化合物是5-HT5A受体拮抗剂，可用于预防和/或治疗抑郁症，焦虑障碍，精神分裂症，恐慌症，广场恐惧症，社交恐惧症，强迫症，创伤后应激障碍，疼痛， 记忆障碍，痴呆，饮食行为障碍，性功能障碍，睡眠障碍，滥用药物，运动障碍如帕金森病，精神病或胃肠疾病。

    2-aminoquinoline derivatives
    7.
    发明授权
    2-aminoquinoline derivatives 失效
    2-氨基喹啉衍生物

    公开(公告)号：US07994324B2

    公开(公告)日：2011-08-09

    申请号：US12394092

    申请日：2009-02-27

    申请人： Sabine Kolczewski ,  Claus Riemer ,  Olivier Roche ,  Lucinda Steward ,  Juergen Wichmann ,  Thomas Woltering

    发明人： Sabine Kolczewski ,  Claus Riemer ,  Olivier Roche ,  Lucinda Steward ,  Juergen Wichmann ,  Thomas Woltering

    IPC分类号： C07D215/38

    CPC分类号： C07D215/38 ,  C07D215/48 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12

    摘要： The present invention is concerned with 2-aminoquinoline derivatives, in particular compounds of formula (I) wherein R1 and R2 are as described herein, pharmaceutical compositions containing such compounds, and methods for their manufacture. The compounds of the invention are 5-HT5A receptor antagonists useful in the prevention and/or treatment of depression, anxiety disorders, schizophrenia, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, pain, memory disorders, dementia, disorders of eating behaviors, sexual dysfunction, sleep disorders, abuse of drugs, motor disorders such as Parkinson's disease, psychiatric disorders or gastrointestinal disorders.

    摘要翻译： 本发明涉及2-氨基喹啉衍生物，特别是式（I）的化合物，其中R 1和R 2如本文所述，含有这些化合物的药物组合物及其制备方法。 本发明的化合物是可用于预防和/或治疗抑郁症，焦虑障碍，精神分裂症，恐慌症，广场恐怖症，社会恐惧症，强迫症，创伤后应激障碍，疼痛，记忆障碍， 痴呆症，饮食行为障碍，性功能障碍，睡眠障碍，药物滥用，运动障碍如帕金森病，精神疾病或胃肠疾病。

    2-aminoquinolines
    8.
    发明授权
    2-aminoquinolines 失效
    2-氨基喹啉

    公开(公告)号：US07989628B2

    公开(公告)日：2011-08-02

    申请号：US12394083

    申请日：2009-02-27

    申请人： Sabine Kolczewski ,  Claus Riemer ,  Olivier Roche ,  Lucinda Steward ,  Juergen Wichmann ,  Thomas Woltering

    发明人： Sabine Kolczewski ,  Claus Riemer ,  Olivier Roche ,  Lucinda Steward ,  Juergen Wichmann ,  Thomas Woltering

    IPC分类号： C07D215/38

    CPC分类号： C07D215/38 ,  C07D405/12

    摘要： The present invention is concerned with 2-aminoquinoline derivatives of formula I wherein Z, R1, and Ar1 are as defined herein, pharmaceutical compositions containing them, methods for their manufacture. The compounds are 5-HT5A receptor antagonists and are useful in the prevention and/or treatment of depression, anxiety disorders, schizophrenia, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, pain, memory disorders, dementia, disorders of eating behaviors, sexual dysfunction, sleep disorders, abuse of drugs, motor disorders such as Parkinson's disease, psychiatric disorders or gastrointestinal disorders.

    摘要翻译： 本发明涉及式I的2-氨基喹啉衍生物，其中Z，R 1和Ar 1如本文所定义，含有它们的药物组合物，其制备方法。 这些化合物是5-HT5A受体拮抗剂，可用于预防和/或治疗抑郁症，焦虑障碍，精神分裂症，恐慌症，广场恐怖症，社交恐惧症，强迫症，创伤后应激障碍，疼痛，记忆障碍，痴呆 饮食行为障碍，性功能障碍，睡眠障碍，药物滥用，运动障碍如帕金森病，精神病或胃肠疾病。

    6-SUBSTITUTED BENZOXAZINES
    9.
    发明申请
    6-SUBSTITUTED BENZOXAZINES 失效
    6-取代苯并噻唑

    公开(公告)号：US20100063037A1

    公开(公告)日：2010-03-11

    申请号：US12549745

    申请日：2009-08-28

    申请人： Sabine Kolczewski ,  Olivier Roche ,  Lucinda Steward ,  Juergen Wichmann ,  Thomas Woltering

    发明人： Sabine Kolczewski ,  Olivier Roche ,  Lucinda Steward ,  Juergen Wichmann ,  Thomas Woltering

    IPC分类号： A61K31/541 ,  C07D265/18 ,  A61K31/536 ,  C07D417/12

    CPC分类号： C07D265/18 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D451/02 ,  C07D498/08

    摘要： The present invention is concerned with 6-substituted benzoxazine derivatives of formula (I) wherein X, Y, R1 and R2 are as described herein, their manufacture, and pharmaceutical compositions containing them. The active compounds of the present invention are 5-HT5A receptor antagonists, useful in the prevention and/or treatment of depression, anxiety disorders, schizophrenia, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, pain, memory disorders, dementia, disorders of eating behaviors, sexual dysfunction, sleep disorders, abuse of drugs, motor disorders, Parkinson's disease, psychiatric disorders or gastrointestinal disorders.

    摘要翻译： 本发明涉及式（I）的6-取代苯并恶嗪衍生物，其中X，Y，R 1和R 2如本文所述，其制备和含有它们的药物组合物。 本发明的活性化合物是可用于预防和/或治疗抑郁症，焦虑障碍，精神分裂症，惊恐障碍，广场恐怖症，社交恐惧症，强迫症，强迫症，创伤后应激障碍，疼痛， 记忆障碍，痴呆，饮食行为障碍，性功能障碍，睡眠障碍，药物滥用，运动障碍，帕金森病，精神病或胃肠疾病。