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公开(公告)号：US20150232501A1
公开(公告)日：2015-08-20
申请号：US14421249
申请日：2013-08-27
申请人： Sampath-Kumar ANADAN , Virender Singh AULAKH , Martijn FENAUX , Xiaodong LIN , Liang MAO , Oliver SAUNDERS , Zachary Kevin SWEENEY , Fumiaki YOKOKAWA , Weidong ZHONG
发明人： Sampath-Kumar Anandan , Virender Singh Aulakh , Martijn Fenaux , Xiaodong Lin , Liang Mao , Oliver Saunders , Zachary Kevin Sweeney , Fumiaki Yokokawa , Weidong Zhong
IPC分类号： C07H19/10 , A61K31/7068 , A61K45/06 , A61K31/7072
CPC分类号： A61K31/7072 , A61K31/7068 , A61K45/06 , A61K47/22 , C07H19/06 , C07H19/067 , C07H19/10
摘要： The present invention provides a compound of formula A: or a pharmaceutically acceptable salt thereof, wherein B, Q, R1, R5, R6, R7, R8 and Z are as defined herein, which is a 2′-branched nucleoside useful for the treatment or prevention of viral infections, particularly dengue fever, yellow fever, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, Kunjin virus, Murray Valley encephalitis, St Louis encephalitis, Omsk hemorrhagic fever virus, bovine viral diarrhea virus, Zika virus and Hepatitis C virus.
摘要翻译： 本发明提供式A化合物或其药学上可接受的盐，其中B，Q，R 1，R 5，R 6，R 7，R 8和Z如本文所定义，其为可用于治疗的2'-支链核苷 或预防病毒感染，特别是登革热，黄热病，西尼罗病毒，日本脑炎病毒，蜱传脑炎病毒，昆金病毒，墨累谷脑炎，圣路易脑炎，鄂木斯克出血热病毒，牛病毒性腹泻病毒，Zika病毒 和丙型肝炎病毒。
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公开(公告)号：US09556216B2
公开(公告)日：2017-01-31
申请号：US14421249
申请日：2013-08-27
申请人： Sampath-Kumar Anandan , Virender Singh Aulakh , Martijn Fenaux , Xiaodong Lin , Liang Mao , Oliver Saunders , Zachary Kevin Sweeney , Fumiaki Yokokawa , Weidong Zhong
发明人： Sampath-Kumar Anandan , Virender Singh Aulakh , Martijn Fenaux , Xiaodong Lin , Liang Mao , Oliver Saunders , Zachary Kevin Sweeney , Fumiaki Yokokawa , Weidong Zhong
IPC分类号： C07H19/10 , A61K31/7072 , A61K31/7068 , A61K45/06
CPC分类号： A61K31/7072 , A61K31/7068 , A61K45/06 , A61K47/22 , C07H19/06 , C07H19/067 , C07H19/10
摘要： The present invention provides a compound of formula A: or a pharmaceutically acceptable salt thereof, wherein B, Q, R1, R5, R6, R7, R8 and Z are as defined herein, which is a 2′-branched nucleoside useful for the treatment or prevention of viral infections, particularly dengue fever, yellow fever, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, Kunjin virus, Murray Valley encephalitis, St Louis encephalitis, Omsk hemorrhagic fever virus, bovine viral diarrhea virus, Zika virus and Hepatitis C virus.
摘要翻译： 本发明提供式A化合物或其药学上可接受的盐，其中B，Q，R 1，R 5，R 6，R 7，R 8和Z如本文所定义，其为可用于治疗的2'-支链核苷 或预防病毒感染，特别是登革热，黄热病，西尼罗病毒，日本脑炎病毒，蜱传脑炎病毒，昆金病毒，墨累谷脑炎，圣路易脑炎，鄂木斯克出血热病毒，牛病毒性腹泻病毒，Zika病毒 和丙型肝炎病毒。
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公开(公告)号：US20160129103A1
公开(公告)日：2016-05-12
申请号：US14940799
申请日：2015-11-13
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2750/10022 , C12N2750/10034 , C12N2750/10061
摘要： The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric infectious DNA clone and its derived, avirulent chimeric virus are constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position. The chimeric virus advantageously retains the nonpathogenic phenotype of PCV1 but elicits specific immune responses against the pathogenic PCV2. The invention further embraces the immunogenic polypeptide expression products. In addition, the invention encompasses two mutations in the PCV2 immunogenic capsid gene and protein, and the introduction of the ORF2 mutations in the chimeric clones.
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公开(公告)号：US09889187B2
公开(公告)日：2018-02-13
申请号：US14940799
申请日：2015-11-13
IPC分类号： A61K39/12 , C12N7/00 , C07K14/005 , A61K39/00
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2750/10022 , C12N2750/10034 , C12N2750/10061
摘要： The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric infectious DNA clone and its derived, avirulent chimeric virus are constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position. The chimeric virus advantageously retains the nonpathogenic phenotype of PCV1 but elicits specific immune responses against the pathogenic PCV2. The invention further embraces the immunogenic polypeptide expression products. In addition, the invention encompasses two mutations in the PCV2 immunogenic capsid gene and protein, and the introduction of the ORF2 mutations in the chimeric clones.
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5.发明授权Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof 有权嵌合感染性DNA克隆，嵌合型猪圆环病毒及其用途公开(公告)号：US07276353B2
公开(公告)日：2007-10-02
申请号：US10314512
申请日：2002-12-09
CPC分类号： C07K14/005 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , C12N7/00 , C12N2750/10022 , C12N2750/10034 , C12N2750/10061
摘要： The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric infectious DNA clone and its derived, avirulent chimeric virus are constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position. The chimeric virus advantageously retains the nonpathogenic phenotype of PCV1 but elicits specific immune responses against the pathogenic PCV2. The invention further embraces the immunogenic polypeptide expression products.
摘要翻译： 本发明涉及感染性DNA克隆，猪圆环病毒感染性嵌合DNA克隆（PCV），疫苗和保护猪免受病毒感染或PCV2引起的断奶后多系统消耗综合征（PMWS）的方法。 新的嵌合感染性DNA克隆及其衍生的无毒性嵌合病毒由非致病性PCV1构建，其中致病性PCV2的免疫原性ORF基因替代非致病性PCV1的基因，优选在相同的位置。 嵌合病毒有利地保留了PCV1的非病原性表型，但引发针对致病性PCV2的特异性免疫应答。 本发明还包括免疫原性多肽表达产物。
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公开(公告)号：US09211324B2
公开(公告)日：2015-12-15
申请号：US13268008
申请日：2011-10-07
IPC分类号： A61K39/12 , C07K14/005 , C12N7/00 , A61K39/00
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2750/10022 , C12N2750/10034 , C12N2750/10061
摘要： The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric infectious DNA clone and its derived, avirulent chimeric virus are constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position. The chimeric virus advantageously retains the nonpathogenic phenotype of PCV1 but elicits specific immune responses against the pathogenic PCV2. The invention further embraces the immunogenic polypeptide expression products. In addition, the invention encompasses two mutations in the PCV2 immunogenic capsid gene and protein, and the introduction of the ORF2 mutations in the chimeric clones.
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7.发明申请CHIMERIC INFECTIOUS DNA CLONES, CHIMERIC PORCINE CIRCOVIRUSES AND USES THEREOF 有权CHIMERIC感染性DNA克隆及其用途及其用途公开(公告)号：US20100055122A1
公开(公告)日：2010-03-04
申请号：US12539540
申请日：2009-08-11
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2750/10022 , C12N2750/10034 , C12N2750/10061
摘要： The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2, The new chimeric infectious DNA clone and its derived, avirulent chimeric virus are constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position. The chimeric virus advantageously retains the nonpathogenic phenotype of PCV1 but elicits specific immune responses against the pathogenic PCV2. The invention further embraces the immunogenic polypeptide expression products. In addition, the invention encompasses two mutations in the PCV2 immunogenic capsid gene and protein, and the introduction of the ORF2 mutations in the chimeric clones.
摘要翻译： 本发明涉及感染性DNA克隆，猪圆环病毒感染性嵌合DNA克隆（PCV），疫苗和保护猪免受PCV2引起的病毒感染或断奶后多系统消耗综合征（PMWS）的手段。新的嵌合感染性DNA克隆及其衍生 ，无病毒嵌合病毒由非致病性PCV1构建，其中致病性PCV2的免疫原性ORF基因替代非致病性PCV1的基因，优选在相同的位置。 嵌合病毒有利地保留了PCV1的非病原性表型，但引发针对致病性PCV2的特异性免疫应答。 本发明还包括免疫原性多肽表达产物。 此外，本发明包括PCV2免疫原性衣壳蛋白基因和蛋白质中的两个突变，以及在嵌合克隆中引入ORF2突变。
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8.发明申请Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof 有权嵌合感染性DNA克隆，嵌合型猪圆环病毒及其用途公开(公告)号：US20080226666A1
公开(公告)日：2008-09-18
申请号：US11893182
申请日：2007-08-15
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2750/10022 , C12N2750/10034 , C12N2750/10061
摘要： The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric infectious DNA clone and its derived, avirulent chimeric virus are constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position. The chimeric virus advantageously retains the nonpathogenic phenotype of PCV1 but elicits specific immune responses against the pathogenic PCV2. The invention further embraces the immunogenic polypeptide expression products. In addition, the invention encompasses two mutations in the PCV2 immunogenic capsid gene and protein, and the introduction of the ORF2 mutations in the chimeric clones.
摘要翻译： 本发明涉及感染性DNA克隆，猪圆环病毒感染性嵌合DNA克隆（PCV），疫苗和保护猪免受病毒感染或PCV2引起的断奶后多系统消耗综合征（PMWS）的方法。 新的嵌合感染性DNA克隆及其衍生的无毒性嵌合病毒由非致病性PCV1构建，其中病原性PCV2的免疫原性ORF基因替代非致病性PCV1的基因，优选在相同的位置。 嵌合病毒有利地保留了PCV1的非病原性表型，但引发针对致病性PCV2的特异性免疫应答。 本发明还包括免疫原性多肽表达产物。 此外，本发明包括PCV2免疫原性衣壳蛋白基因和蛋白质中的两个突变，以及在嵌合克隆中引入ORF2突变。
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9.发明申请Differential PCR-RFLP assay for detecting and distinguishing between nonpathogenic PCV-1 and pathogenic PCV-2 审中-公开差异PCR-RFLP检测和鉴别非致病性PCV-1与致病性PCV-2公开(公告)号：US20050147966A1
公开(公告)日：2005-07-07
申请号：US11040447
申请日：2005-01-21
申请人： Xiang-Jin Meng , Martijn Fenaux
发明人： Xiang-Jin Meng , Martijn Fenaux
摘要： The present invention relates to a method for detecting and differentiating PCV infections in a biological sample taken from a pig which involves amplifying a fragment from an extracted nucleic acid; digesting the fragment with a suitable restriction enzyme such as the unique NcoI restriction enzyme; forming a restriction fragment length polymorphism pattern; and then detecting the presence or absence of a PCV isolate. The invention further concerns the new oligonucleotide primers for differentiating PCV infections comprising a nucleotide sequence selected from the group consisting of MCV1 having a nucleotide sequence set forth in SEQ ID NO:1 and MCV2 having a nucleotide sequence set forth in SEQ ID NO:2. Moreover, this invention provides a novel kit for detecting and distinguishing PCV infections that includes the new oligonucleotide primers and the suitable restriction enzyme.
摘要翻译： 本发明涉及一种用于检测和分化取自猪的生物样品中的PCV感染的方法，其涉及从提取的核酸扩增片段; 用合适的限制酶如独特的NcoI限制酶消化片段; 形成限制性片段长度多态性模式; 然后检测PCV分离物的存在或不存在。 本发明还涉及用于分化PCV感染的新的寡核苷酸引物，其包含选自具有SEQ ID NO：1所示核苷酸序列的MCV1和具有SEQ ID NO：2所示核苷酸序列的MCV2的核苷酸序列。 此外，本发明提供了用于检测和鉴别PCV感染的新型试剂盒，其包括新的寡核苷酸引物和合适的限制酶。
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公开(公告)号：US10507238B2
公开(公告)日：2019-12-17
申请号：US15875892
申请日：2018-01-19
IPC分类号： A61K39/12 , C12N7/00 , C07K14/005 , A61K39/00
摘要： The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric infectious DNA clone and its derived, avirulent chimeric virus are constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position. The chimeric virus advantageously retains the nonpathogenic phenotype of PCV1 but elicits specific immune responses against the pathogenic PCV2. The invention further embraces the immunogenic polypeptide expression products. In addition, the invention encompasses two mutations in the PCV2 immunogenic capsid gene and protein, and the introduction of the ORF2 mutations in the chimeric clones.
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