摘要:
The present invention provides a compound of formula A: or a pharmaceutically acceptable salt thereof, wherein B, Q, R1, R5, R6, R7, R8 and Z are as defined herein, which is a 2′-branched nucleoside useful for the treatment or prevention of viral infections, particularly dengue fever, yellow fever, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, Kunjin virus, Murray Valley encephalitis, St Louis encephalitis, Omsk hemorrhagic fever virus, bovine viral diarrhea virus, Zika virus and Hepatitis C virus.
摘要:
The present invention provides a compound of formula A: or a pharmaceutically acceptable salt thereof, wherein B, Q, R1, R5, R6, R7, R8 and Z are as defined herein, which is a 2′-branched nucleoside useful for the treatment or prevention of viral infections, particularly dengue fever, yellow fever, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, Kunjin virus, Murray Valley encephalitis, St Louis encephalitis, Omsk hemorrhagic fever virus, bovine viral diarrhea virus, Zika virus and Hepatitis C virus.
摘要:
A pseudo wire label reflector, based on a existing label distribution router, further includes: a mode management unit, for determining the mode for switching and transferring a pseudo wire label message; a first session management unit, for saving the support information that LDP signaling session connection supports the pseudo wire label reflecting capacity; a first pseudo wire label receiving unit, for receiving a pseudo wire label message; a first pseudo wire management unit, for saving the switched pseudo wire state and deciding whether to modify the pseudo wire label message according to the switch and transfer mode determined by the mode management unit; a first pseudo wire label sending unit, for sending the pseudo wire label message. The invention also provides an edge apparatus and a L2 VPN. The present invention makes PE equipments participating pseudo wire service to set up PSN tunnel and LDP signaling session connection with the pseudo wire label reflector by introducing the pseudo wire label reflector and extending the capacity that the current edge apparatus supports the pseudo wire label reflector.
摘要:
This invention provides efficient HCV replicase complexes comprising novel RNA template and primer pair. Assay systems are also provided, which use such complexes, for detecting replicase activity, quantitatively studying the kinetics and mechanism of HCV NS5B-catalyzed nucleotide incorporation, and identifying inhibitors of HCV replicase. The assay systems use small and well-defined synthetic RNAs which allow efficient assembly of all catalytic components in the quaternary complex for HCV NS5B-directed RNA replication. Specific template-primer requirements for efficient RNA synthesis by HCV NS5B replicase are provided for use in assay systems.
摘要:
A pseudo wire label reflector, based on a existing label distribution router, further includes: a mode management unit, for determining the mode for switching and transferring a pseudo wire label message; a first session management unit, for saving the support information that LDP signaling session connection supports the pseudo wire label reflecting capacity; a first pseudo wire label receiving unit, for receiving a pseudo wire label message; a first pseudo wire management unit, for saving the switched pseudo wire state and deciding whether to modify the pseudo wire label message according to the switch and transfer mode determined by the mode management unit; a first pseudo wire label sending unit, for sending the pseudo wire label message. The invention also provides an edge apparatus, a L2 VPN and a method for providing pseudo wire service in PSN. The present invention makes PE equipments participating pseudo wire service to set up PSN tunnel and LDP signaling session connection with the pseudo wire label reflector by introducing the pseudo wire label reflector and extending the capacity that the current edge apparatus supports the pseudo wire label reflector.
摘要:
The present invention relates to identification of the features of an RNA template that provide for efficient “copy-back” self-priming activity of hepatitis C virus replicase. This activity can be used to screen for anti-HCV replicase compounds, or to characterize the biological relevance of lead compounds that have already been identified. The specific features of the optimal RNA templates can be used for developing a system to characterize HCV NS5B polymerase mechanistically and kinetically, and for designing small RNA molecules to co-crystallize with HCV NS5B polymerase.
摘要:
This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.
摘要:
A pseudo wire label reflector, based on a existing label distribution router, further includes: a mode management unit, for determining the mode for switching and transferring a pseudo wire label message; a first session management unit, for saving the support information that LDP signaling session connection supports the pseudo wire label reflecting capacity; a first pseudo wire label receiving unit, for receiving a pseudo wire label message; a first pseudo wire management unit, for saving the switched pseudo wire state and deciding whether to modify the pseudo wire label message according to the switch and transfer mode determined by the mode management unit; a first pseudo wire label sending unit, for sending the pseudo wire label message. The invention also provides an edge apparatus and a L2 VPN. The present invention makes PE equipments participating pseudo wire service to set up PSN tunnel and LDP signaling session connection with the pseudo wire label reflector by introducing the pseudo wire label reflector and extending the capacity that the current edge apparatus supports the pseudo wire label reflector.
摘要:
This invention concerns certain 5-(substituted amino) isothiazoles, compounds of Formula I, and salts thereof, where Q is CN, NHCONRaRb, or CONRaRb, where Ra and Rb are defined herein; and R1 is cyclohexyl, adamantan-1-yl, indan-1-yl, phenyl, benzyl, pyridyl, pyridylmethyl, or pyrimidyl, where all aromatic R1 groups are optionally substituted, provided that when R1 is phenyl, then R1 bears at least one non-alkyl substituent, and further provided that R1 is not 4-chloro-3-trichloromethyl-phenyl; The invention also concerns the tautomeric 5-(substituted amino)-isothiazol-3(2H)-ones, and the use of such compounds to treat Hepatitis C infection. It also concerns thiocarbamoyl acetamides, which are synthetic precursors to the isothiazoles.
摘要翻译:本发明涉及某些5-(取代氨基)异噻唑,式I化合物及其盐,其中Q为CN,NHCONR a R b B或CONR 其中R a a和R bb在本文中定义;其中R a,R b和R b都定义如上。 和R 1是环己基,金刚烷-1-基,茚满-1-基,苯基,苄基,吡啶基,吡啶基甲基或嘧啶基,其中所有芳族R 1〜 任选地被取代,条件是当R 1为苯基时,R 1至少具有一个非烷基取代基,并且进一步地,R 1' 不是4-氯-3-三氯甲基 - 苯基; 本发明还涉及互变异构5-(取代氨基) - 异噻唑-3(2H) - 酮,以及这些化合物用于治疗丙型肝炎感染的用途。 它还涉及硫代氨基甲酰基乙酰胺,它们是异噻唑的合成前体。