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公开(公告)号：US09637541B2
公开(公告)日：2017-05-02
申请号：US14556911
申请日：2014-12-01
Applicant: Samsung Electronics Co., Ltd.
Inventor： Hyung-Chan Kim , Kyung Eun Kim , Yoon Sook Lee , Mi Young Cho
CPC classification number: C07K16/2863 , A61K2039/505 , C07K16/22 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00
Abstract: An anti-c-Met/anti-Ang2 bispecific antibody, a composition including the anti-c-Met/anti-Ang2 bispecific antibody, and a method of preventing and/or treating a cancer in a subject including administering the anti-c-Met/anti-Ang2 bispecific antibody to the subject.
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公开(公告)号：US20150210761A1
公开(公告)日：2015-07-30
申请号：US14606441
申请日：2015-01-27
Applicant: Samsung Electronics Co., Ltd.
Inventor： Kyung Eun Kim , Yoon Sook Lee , Sang Yeul Han , Hyung-Chan Kim , Kwang Hoon Lee , Hyo Seon Lee , Seok Kyun Kim
CPC classification number: C07K16/22 , A61K2039/505 , C07K16/3046 , C07K2317/34 , C07K2317/76 , C07K2317/92 , G01N33/6872 , G01N2333/515 , G01N2500/04
Abstract: An Ang2 specific antibody, a method of preventing and/or treating a disease related to the activation and/or overproduction (overexpression) of Ang2 by administering the antibody to a subject, and a method of screening a candidate substance for diagnosing, preventing, or treating a disease related to activation or overproduction of Ang2.
Abstract translation: Ang2特异性抗体，通过向受试者施用抗体来预防和/或治疗与激动和/或过量产生（过表达）Ang2有关的疾病的方法，以及筛选候选物质的方法，用于诊断，预防或/ 治疗与Ang2的活化或过量产生相关的疾病。
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3.发明申请公开(公告)号：US20140302039A1
公开(公告)日：2014-10-09
申请号：US14244709
申请日：2014-04-03
Applicant: Samsung Electronics Co., Ltd.
Inventor： Yun Ju JEONG , Kyung Ah Kim , Kyung Eun Kim , Chungho Kim
IPC: A61K39/395
CPC classification number: C07K16/2863 , A61K2039/507 , C07K16/22 , C07K2317/24 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: A method for inhibiting angiogenesis and treating angiogenesis related diseases comprising administering an anti-c-Met antibody or an antigen-binding fragment thereof, and an anti-Ang-2 antibody or an antigen-binding fragment thereof, in combination simultaneously or sequentially; as well as related compositions and methods.
Abstract translation: 一种抑制血管生成和治疗血管发生相关疾病的方法，包括同时或依次给予抗c-Met抗体或其抗原结合片段，以及抗Ang-2抗体或其抗原结合片段; 以及相关的组合物和方法。
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公开(公告)号：US09725513B2
公开(公告)日：2017-08-08
申请号：US14336812
申请日：2014-07-21
Applicant: Samsung Electronics Co., Ltd.
Inventor： Kwang Hoon Lee , Hyung-Chan Kim , Sang Yeul Han , Seok Kyun Kim , Kyung Eun Kim
CPC classification number: C07K16/2863 , C07K14/71 , C07K2317/73 , C07K2317/92 , C07K2318/20 , C07K2319/30
Abstract: A fusion polypeptide capable of binding simultaneously to angiopoietin 2, VEGF-C and VEGF-D; or capable of binding simultaneously to VEGF-C and VEGF-D, and methods for the preparation and use thereof.
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5.发明授权公开(公告)号：US09556275B2
公开(公告)日：2017-01-31
申请号：US14244709
申请日：2014-04-03
Applicant: Samsung Electronics Co., Ltd.
Inventor： Yun Ju Jeong , Kyung Ah Kim , Kyung Eun Kim , Chungho Kim
CPC classification number: C07K16/2863 , A61K2039/507 , C07K16/22 , C07K2317/24 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: A method for inhibiting angiogenesis and treating angiogenesis related diseases comprising administering an anti-c-Met antibody or an antigen-binding fragment thereof, and an anti-Ang-2 antibody or an antigen-binding fragment thereof, in combination simultaneously or sequentially; as well as related compositions and methods.
Abstract translation: 一种抑制血管生成和治疗血管发生相关疾病的方法，包括同时或依次给予抗c-Met抗体或其抗原结合片段，以及抗Ang-2抗体或其抗原结合片段; 以及相关的组合物和方法。
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Patent Agency Ranking
6.发明授权Peptide for inhibition of binding between angiopoietin-2 and integrin and use thereof 有权抑制血管生成素-2与整联蛋白结合的肽及其用途公开(公告)号：US09193768B2
公开(公告)日：2015-11-24
申请号：US14058069
申请日：2013-10-18
Applicant: Samsung Electronics Co., Ltd.
Inventor： Sang Yeul Han , Chung Ho Kim , Kyung Eun Kim , Hyung-Chan Kim , Kwang-Hoon Lee , Hyo Seon Lee
IPC: C07K14/00 , C07K14/515 , A61K38/00
CPC classification number: A61K38/1891 , A61K38/00 , C07K14/00 , C07K14/001 , C07K14/515 , C07K2319/30 , C07K2319/70
Abstract: There are provided an angiopoietin-2 (Ang2) derived peptides, polypeptides, and peptide complexes, and a method for inhibition of binding between Ang2 and integrin and prevention and/or treatment of a disease caused by the activation of Ang2 or the binding between Ang2 and integrin using the peptide, polypeptides, and peptide complexes.
Abstract translation: 提供了血管生成素-2（Ang2）衍生的肽，多肽和肽复合物，以及抑制Ang2和整联蛋白之间结合的方法，以及预防和/或治疗Ang2的激活或Ang2的结合引起的疾病 和使用肽，多肽和肽复合物的整联蛋白。
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公开(公告)号：US20150037343A1
公开(公告)日：2015-02-05
申请号：US14447242
申请日：2014-07-30
Applicant: Samsung Electronics Co., Ltd.
Inventor： Seok Kyun KIM , Sang Yeul Han , Kwang Hoon Lee , Kyung Eun Kim , Chung Ho Kim , Yong In Kim , Hyung-Chan Kim , Yoon Sook Lee , Hyo Seon Lee
CPC classification number: C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/622 , C07K2317/76 , C07K2317/92 , G01N2500/04 , Y02A50/412
Abstract: An Ang2 specific antibody, a method of inhibiting angiogenesis or a method of treating a disease related to the activation and/or overproduction of Ang2 using the antibody, and a composition for diagnosing a disease related to the activation and/or overproduction of Ang2 including the antibody.
Abstract translation: Ang2特异性抗体，抑制血管生成的方法或使用该抗体治疗与Ang2的活化和/或过量产生有关的疾病的方法，以及用于诊断与Ang2的活化和/或过量产生有关的疾病的组合物，包括 抗体。
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公开(公告)号：US10246511B2
公开(公告)日：2019-04-02
申请号：US15667424
申请日：2017-08-02
Applicant: Samsung Electronics Co., Ltd.
Inventor： Kwang Hoon Lee , Hyung-Chan Kim , Sang Yeul Han , Seok Kyun Kim , Kyung Eun Kim
Abstract: A fusion polypeptide capable of binding simultaneously to angiopoietin 2, VEGF-C and VEGF-D; or capable of binding simultaneously to VEGF-C and VEGF-D, and methods for the preparation and use thereof.
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公开(公告)号：US10047154B2
公开(公告)日：2018-08-14
申请号：US14447242
申请日：2014-07-30
Applicant: Samsung Electronics Co., Ltd.
Inventor： Seok Kyun Kim , Sang Yeul Han , Kwang Hoon Lee , Kyung Eun Kim , Chung Ho Kim , Yong In Kim , Hyung-Chan Kim , Yoon Sook Lee , Hyo Seon Lee
IPC: A61K39/395 , A61K39/00 , C07K16/00 , C07K16/22
Abstract: An Ang2 specific antibody, a method of inhibiting angiogenesis or a method of treating a disease related to the activation and/or overproduction of Ang2 using the antibody, and a composition for diagnosing a disease related to the activation and/or overproduction of Ang2 including the antibody.
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10.发明授权Antibodies or antigen-binding fragments thereof specifically binding to VEGF-C and use thereof 有权与VEGF-C特异性结合的抗体或其抗原结合片段及其用途公开(公告)号：US09562093B2
公开(公告)日：2017-02-07
申请号：US14518502
申请日：2014-10-20
Applicant: Samsung Electronics Co., Ltd.
Inventor： Seok Kyun Kim , Sang Yeul Han , Kwang Hoon Lee , Kyung Eun Kim
IPC: A61K39/395 , C07K16/18 , C07K16/22
CPC classification number: C07K16/22 , C07K2317/21 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: An antibody or antigen-binding fragment thereof that specifically binds to and inhibits VEGF-C and uses thereof in a method of inhibiting angiogenesis and a method of preventing, treating, and/or diagnosing a disease associated with activation and/or overexpression of VEGF-C, using the antibody, and a method of detecting the presence of VEGF-C in a sample.
Abstract translation: 特异性结合并抑制VEGF-C的抗体或其抗原结合片段及其在抑制血管生成的方法中的用途及其预防，治疗和/或诊断与VEGF-活化和/或过表达有关的疾病的方法， 使用抗体，以及检测样品中VEGF-C的存在的方法。
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