利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

18 条记录 (耗时 0.032 秒)

    Total synthesis of Salinosporamide A and analogs thereof
    3.
    发明授权
    Total synthesis of Salinosporamide A and analogs thereof 有权
    Salinosporamide A及其类似物的全合成

    公开(公告)号：US08003802B2

    公开(公告)日：2011-08-23

    申请号：US12399382

    申请日：2009-03-06

    申请人： Taotao Ling ,  Samuel Danishefsky

    发明人： Taotao Ling ,  Samuel Danishefsky

    IPC分类号： C07D498/14 ,  C07D487/04

    CPC分类号： C07D487/14 ,  C07D487/04

    摘要： The present application relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs that includes forming a compound of formula (VIII).

    摘要翻译： 本申请涉及某些化合物和制备可用于化学和医学领域的某些化合物的方法。 具体来说，本文描述了制备各种化合物和中间体以及化合物和中间体本身的方法。 更具体地说，本文描述了合成Salinosporamide A及其类似物的方法，其包括形成式（VIII）化合物。

    Total synthesis of salinosporamide A and analogs thereof
    4.
    发明授权
    Total synthesis of salinosporamide A and analogs thereof 失效
    salinosporamide A及其类似物的全合成

    公开(公告)号：US08314251B2

    公开(公告)日：2012-11-20

    申请号：US13184356

    申请日：2011-07-15

    申请人： Taotao Ling ,  Samuel Danishefsky

    发明人： Taotao Ling ,  Samuel Danishefsky

    IPC分类号： C07D263/00 ,  C07D498/04

    CPC分类号： C07D487/14 ,  C07D487/04

    摘要： The present application relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs that includes forming a compound of formula (VIII).

    摘要翻译： 本申请涉及某些化合物和制备可用于化学和医学领域的某些化合物的方法。 具体来说，本文描述了制备各种化合物和中间体以及化合物和中间体本身的方法。 更具体地说，本文描述了合成Salinosporamide A及其类似物的方法，其包括形成式（VIII）化合物。

    TOTAL SYNTHESIS OF SALINOSPORAMIDE A AND ANALOGS THEREOF
    7.
    发明申请
    TOTAL SYNTHESIS OF SALINOSPORAMIDE A AND ANALOGS THEREOF 失效
    总的合成磺酰胺A及其类似物

    公开(公告)号：US20110269969A1

    公开(公告)日：2011-11-03

    申请号：US13184356

    申请日：2011-07-15

    申请人： Taotao Ling ,  Samuel Danishefsky

    发明人： Taotao Ling ,  Samuel Danishefsky

    IPC分类号： C07D498/04 ,  C07D491/048

    CPC分类号： C07D487/14 ,  C07D487/04

    摘要： The present application relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs that includes forming a compound of formula (VIII).

    摘要翻译： 本申请涉及某些化合物和制备可用于化学和医学领域的某些化合物的方法。 具体来说，本文描述了制备各种化合物和中间体以及化合物和中间体本身的方法。 更具体地说，本文描述了合成Salinosporamide A及其类似物的方法，其包括形成式（VIII）化合物。

    Method for preparing polyfunctionalized peptides and/or proteins via native chemical ligation
    8.
    发明申请
    Method for preparing polyfunctionalized peptides and/or proteins via native chemical ligation 失效
    通过天然化学连接制备多官能化肽和/或蛋白质的方法

    公开(公告)号：US20070173636A1

    公开(公告)日：2007-07-26

    申请号：US10570556

    申请日：2004-09-03

    申请人： Samuel Danishefsky ,  J. Warren

    发明人： Samuel Danishefsky ,  J. Warren

    IPC分类号： C07K9/00 ,  A61K38/14

    CPC分类号： C07K1/1077 ,  C07K1/04 ,  C07K9/001 ,  C07K9/003 ,  C07K14/005 ,  C12N2740/16122

    摘要： The present invention provides a method for preparing polyfunctionalized peptides and/or proteins at non-adjacent designated sites via native chemical ligation. In certain embodiments, the inventive method is a method for preparing a polyfunctionalized peptide comprising a peptidic backbone made up of four or more amino acids, wherein two or more non-adjacent amino acids are independently subsituted with a moiety having the structure: wherein A and L1 are as defined herein. In certain other embodiments, the inventive method allows the preparation of polyfunctionalized peptides having the general structure: wherein A, RP0, RP1, PX1, RX2, L1, to, s, tand q are as defined herein.

    摘要翻译： 本发明提供了通过天然化学连接在非相邻指定位点制备多官能化肽和/或蛋白质的方法。 在某些实施方案中，本发明的方法是制备多功能化肽的方法，所述肽包含由四个或更多个氨基酸组成的肽主链，其中两个或多个不相邻氨基酸与具有以下结构的部分独立地取代：其中A和 L 1如本文所定义。 在某些其他实施方案中，本发明的方法允许制备具有以下通式结构的多官能化肽：其中A，R P0，R P1， R 2，X 2，L 1，...，s，t和q如本文所定义。

    Migrastatin analogs and uses thereof
    9.
    发明申请
    Migrastatin analogs and uses thereof 审中-公开
    Migrastatin类似物及其用途

    公开(公告)号：US20070037783A1

    公开(公告)日：2007-02-15

    申请号：US10551152

    申请日：2004-03-26

    申请人： Xin-Yun Huang ,  Samuel Danishefsky ,  Christoph Gaul ,  Jon Njardarson

    发明人： Xin-Yun Huang ,  Samuel Danishefsky ,  Christoph Gaul ,  Jon Njardarson

    IPC分类号： A61K31/541 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/452 ,  A61K31/427 ,  A61K31/422 ,  A61K31/395 ,  A61K31/4025

    CPC分类号： A61K31/395 ,  A61K31/4025 ,  A61K31/422 ,  A61K31/427 ,  A61K31/452 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541

    摘要： In one aspect, the present invention provides pharmaceutical compositions comprising a therapeutically effective amount of a compound of general formula (I), wherein R1—R6, Ra—RC, Q, Y1, Y2 and n are as defined herein, whereby the composition is formulated for administration to a subject at a dosage between about 0.1 mg/kg to about 50 mg/kg of body weight. In another aspect, the present invention provides a method for treating breast tumor metastasis in a subject comprising administering to a subject in need thereof a therapeutically effective amount of the inventive composition described directly above and a pharmaceutically acceptable carrier, adjuvant or vehicle.

    摘要翻译： 一方面，本发明提供药物组合物，其包含治疗有效量的通式（I）的化合物，其中R 1 -R 6，R 6， Q 1，Y 1，Y 2和n如本文所定义，由此将组合物配制成施用于 剂量为约0.1mg / kg至约50mg / kg体重的受试者。 另一方面，本发明提供一种用于治疗受试者的乳腺肿瘤转移的方法，其包括向有需要的受试者施用治疗有效量的上述直接描述的本发明组合物和药学上可接受的载体，佐剂或媒介物。