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公开(公告)号:US5488116A
公开(公告)日:1996-01-30
申请号:US146704
申请日:1993-11-02
申请人: Samuel J. Danishefsky , William G. Bornmann , Yves Queneau , Thomas V. Magee , Walter J. Krol , John J. Masters , David K. Jung
发明人: Samuel J. Danishefsky , William G. Bornmann , Yves Queneau , Thomas V. Magee , Walter J. Krol , John J. Masters , David K. Jung
IPC分类号: A61K31/335 , C07C13/28 , C07C45/29 , C07C45/59 , C07C49/603 , C07C49/613 , C07C49/687 , C07C49/713 , C07C49/723 , C07C49/737 , C07C49/747 , C07C49/753 , C07C49/757 , C07C255/31 , C07C255/45 , C07C255/46 , C07D305/14 , C07D317/72 , C07D339/08 , C07D493/04 , C07F7/18 , C07D317/70
CPC分类号: C07F7/1856 , C07C255/31 , C07C255/46 , C07C403/08 , C07C403/14 , C07C403/16 , C07C403/20 , C07C45/29 , C07C45/59 , C07C49/613 , C07C49/687 , C07C49/713 , C07C49/723 , C07C49/737 , C07C49/747 , C07C49/753 , C07C49/757 , C07D305/14 , C07D317/72 , C07F7/1852 , C07C2101/14 , C07C2101/16
摘要: The present invention provides three basic routes for the total synthesis of taxol having the structure: ##STR1## The present invention also provides the intermediates produced in the above processes, processes for synthesizing these intermediates as well as analogues of taxol and nortaxol.
摘要翻译: 本发明提供了具有以下结构的紫杉醇的总合成的三种基本途径:本发明还提供了上述方法中制备的中间体,合成这些中间体的方法以及紫杉醇和北美多酚的类似物。
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公开(公告)号:US5527924A
公开(公告)日:1996-06-18
申请号:US350251
申请日:1994-12-05
IPC分类号: A61K31/335 , C07C13/28 , C07C45/29 , C07C45/59 , C07C49/603 , C07C49/613 , C07C49/687 , C07C49/713 , C07C49/723 , C07C49/737 , C07C49/747 , C07C49/753 , C07C49/757 , C07C255/31 , C07C255/45 , C07C255/46 , C07D305/14 , C07D317/72 , C07D339/08 , C07D493/04 , C07F7/18 , C07D317/12
CPC分类号: C07C403/08 , C07C255/31 , C07C255/46 , C07C403/14 , C07C403/16 , C07C403/20 , C07C45/29 , C07C45/59 , C07C49/613 , C07C49/687 , C07C49/713 , C07C49/723 , C07C49/737 , C07C49/747 , C07C49/753 , C07C49/757 , C07D305/14 , C07D317/72 , C07F7/1852 , C07F7/1856 , C07C2101/14 , C07C2101/16
摘要: The present invention provides two basic routes for the total synthesis of taxol having the structure: ##STR1## The present invention also provides the intermediates produced in the above processes, processes for synthesizing these intermediates as well as analogs to taxol. Both the intermediates and analogs to taxol may prove to be valuable anticancer agents.
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公开(公告)号:US5416225A
公开(公告)日:1995-05-16
申请号:US860792
申请日:1992-03-30
IPC分类号: A61K31/335 , C07C13/28 , C07C45/29 , C07C45/59 , C07C49/603 , C07C49/613 , C07C49/687 , C07C49/713 , C07C49/723 , C07C49/737 , C07C49/747 , C07C49/753 , C07C49/757 , C07C255/31 , C07C255/45 , C07C255/46 , C07D305/14 , C07D317/72 , C07D339/08 , C07D493/04 , C07F7/18
CPC分类号: C07C403/08 , C07C255/31 , C07C255/46 , C07C403/14 , C07C403/16 , C07C403/20 , C07C45/29 , C07C45/59 , C07C49/613 , C07C49/687 , C07C49/713 , C07C49/723 , C07C49/737 , C07C49/747 , C07C49/753 , C07C49/757 , C07D305/14 , C07D317/72 , C07F7/1852 , C07F7/1856 , C07C2101/14 , C07C2101/16
摘要: The present invention provides two basic routes for the total synthesis of taxol having the structure: ##STR1## The present invention also provides the intermediates produced in the above processes, processes for synthesizing these intermediates as well as analogs to taxol. Both the intermediates and analogs to taxol may prove to be valuable anticancer agents.
摘要翻译: 本发明提供了具有以下结构的紫杉醇的总合成的两条基本路线:本发明还提供了上述方法中制备的中间体,合成这些中间体的方法以及类似物的紫杉醇。 紫杉醇的中间体和类似物都可能被证明是有价值的抗癌剂。
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公开(公告)号:US4177590A
公开(公告)日:1979-12-11
申请号:US941002
申请日:1978-09-11
CPC分类号: G09F1/12 , A47G1/0605
摘要: The assembly comprises a frame having end and side frame members, each such member including an outside wall. An inclined rear wall and a front lip extend inwardly from the outside wall. An inside wall extends rearwardly from the front lip and has a rear end constituting a ledge for a glass pane, a picture and the like. Each of at least two retaining strips associated with at least two of the frame members has a side wall carrying an inwardly directed flange and an inclined tongue. A retaining strip is applied by inserting the tongue between the rear wall and the outside wall, then pushing the retaining strip toward such outside wall until the flange rests on the backing for the picture.
摘要翻译: 组件包括具有端部和侧框架构件的框架,每个这样的构件包括外壁。 倾斜的后壁和前唇从外壁向内延伸。 内壁从前唇向后延伸,并具有构成玻璃板,图片等的凸缘的后端。 与至少两个框架构件相关联的至少两个保持条中的每一个具有承载向内指向的凸缘和倾斜的舌头的侧壁。 通过将舌片插入后壁和外壁之间来施加保持条,然后将保持条推向该外壁,直到法兰搁在用于图片的背衬上。
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