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    Processes for preparing crystalline and amorphous mupirocin calcium
    4.
    发明授权
    Processes for preparing crystalline and amorphous mupirocin calcium 失效
    制备结晶和无定形莫匹罗星钙的方法

    公开(公告)号：US07737177B2

    公开(公告)日：2010-06-15

    申请号：US10289919

    申请日：2002-11-06

    申请人： Lorant Gyuricza ,  Erszebet Meszaros-Sos ,  Csaba Szabo ,  Claude Singer

    发明人： Lorant Gyuricza ,  Erszebet Meszaros-Sos ,  Csaba Szabo ,  Claude Singer

    IPC分类号： A61K31/335

    CPC分类号： C07D407/06

    摘要： Processes are provided for preparing mupirocin calcium dihydrate from pseudomonic acid in a two phase system by using an organic carboxylate. A highly pure composition of amorphous mupirocin calcium is provided, and processes for its preparation by solvent removal, lyophilization and precipitation with use of an anti-solvent. Pharmaceutical compositions of amorphous form, and methods of using them to treat infections are also provided. Also provided are combined processes for preparing mupirocin calcium dihydrate and amorphous, by producing amorphous form first, followed by conversion of amorphous form into the dihydrate through crystallization from an aqueous solution. Also provided are processes for removing the water of crystallization of the dihydrate to obtain mupirocin calcium anhydrate.

    摘要翻译： 提供了通过使用有机羧酸盐在两相体系中由假单胞菌酸制备莫匹罗星二水合钙的方法。 提供了一种高纯度非晶莫匹罗星钙组合物，以及通过溶剂去除，冻干和使用抗溶剂沉淀制备的方法。 还提供了无定形形式的药物组合物，以及使用它们治疗感染的方法。 还提供了通过首先产生无定形形式，然后通过从水溶液中结晶将无定形形式转化为二水合物，制备莫匹罗星二水合物和无定形物的组合方法。 还提供了去除二水合物结晶水以获得莫匹罗星钙无水物的方法。

    Aztreonam β polymorph with very low residual solvent content
    10.
    发明授权
    Aztreonam β polymorph with very low residual solvent content 有权
    氨丁宁β多晶型物，残留溶剂含量非常低

    公开(公告)号：US07452991B2

    公开(公告)日：2008-11-18

    申请号：US10847123

    申请日：2004-05-17

    申请人： Viktor Gyollai ,  Csaba Szabo ,  Claude Singer ,  Ehud Amir

    发明人： Viktor Gyollai ,  Csaba Szabo ,  Claude Singer ,  Ehud Amir

    IPC分类号： C07D205/085

    CPC分类号： C07D417/12

    摘要： The invention relates to the β polymorph of Aztreonam, which contains less than 2.5% by weight residual solvent and to a process of making said polymorph. In the process of the invention, a polymorph of Aztreonam is dissolved in an absolute C1-6 alcohol in the presence of a base to form a solution, an acid is added to the solution, and the solution is stirred efficiently.

    摘要翻译： 本发明涉及氨曲南的β多晶型物，其含有小于2.5％（重量）的残留溶剂和制备所述多晶型物的方法。 在本发明的方法中，在碱的存在下将氨丁三醇的多晶型物溶解在绝对的C 1-6醇中以形成溶液，向溶液中加入酸，并将溶液 被有效地搅拌。