公开(公告)号：US20090228183A1

公开(公告)日：2009-09-10

申请号：US12074726

申请日：2008-03-05

申请人： Satoru Watabe ,  Hiroyuki Ohno

发明人： Satoru Watabe ,  Hiroyuki Ohno

IPC分类号： B60W40/12

CPC分类号： B60K28/16 ,  B60T8/1706 ,  B60T8/175 ,  B60W2510/0638 ,  B60W2510/0652 ,  B60W2510/1005 ,  B60W2520/10 ,  B60W2710/0616 ,  B60W2710/0666 ,  Y10T477/755

摘要： A slip detection system for a vehicle comprises an engine speed detector configured to detect an engine speed of an engine mounted in the vehicle, an engine speed increase rate detector configured to detect an increase rate in a predetermined time of the engine speed detected by the engine speed detector, and a slip determiner configured to integrate values of increase rates in respective predetermined times, from when the increase rate detected by the engine speed increase rate detector becomes larger than a first threshold until the increase rate becomes smaller than the first threshold, and to determine that a drive wheel of the vehicle is in a slip-state when an integrated value resulting from integration of the values of the increase rates becomes larger than a second threshold.

摘要翻译： 一种用于车辆的滑动检测系统包括：发动机速度检测器，被配置为检测安装在车辆中的发动机的发动机转速;发动机速度增加率检测器，被配置为检测在发动机检测到的发动机转速的预定时间内的增加率 速度检测器和滑动判定器，其被配置为在从发动机速度增加率检测器检测到的增加率变得大于第一阈值直到增加速率变得小于第一阈值时，在各个预定时间内积分增加率的值，以及 当由增加率的值的积分导致的积分值变得大于第二阈值时，确定车辆的驱动轮处于滑动状态。

公开(公告)号：US07957880B2

公开(公告)日：2011-06-07

申请号：US12074726

申请日：2008-03-05

申请人： Satoru Watabe ,  Hiroyuki Ohno

发明人： Satoru Watabe ,  Hiroyuki Ohno

IPC分类号： B60K28/16 ,  B60W10/06 ,  B60W10/02 ,  B60W30/02

CPC分类号： B60K28/16 ,  B60T8/1706 ,  B60T8/175 ,  B60W2510/0638 ,  B60W2510/0652 ,  B60W2510/1005 ,  B60W2520/10 ,  B60W2710/0616 ,  B60W2710/0666 ,  Y10T477/755

摘要： A slip detection system for a vehicle comprises an engine speed detector configured to detect an engine speed of an engine mounted in the vehicle, an engine speed increase rate detector configured to detect an increase rate in a predetermined time of the engine speed detected by the engine speed detector, and a slip determiner configured to integrate values of increase rates in respective predetermined times, from when the increase rate detected by the engine speed increase rate detector becomes larger than a first threshold until the increase rate becomes smaller than the first threshold, and to determine that a drive wheel of the vehicle is in a slip-state when an integrated value resulting from integration of the values of the increase rates becomes larger than a second threshold.

摘要翻译： 一种用于车辆的滑动检测系统包括：发动机速度检测器，被配置为检测安装在车辆中的发动机的发动机转速;发动机速度增加率检测器，被配置为检测在发动机检测到的发动机转速的预定时间内的增加率 速度检测器和滑动判定器，其被配置为在从发动机速度增加率检测器检测到的增加率变得大于第一阈值直到增加速率变得小于第一阈值时，在各个预定时间内积分增加率的值，以及 当由增加率的值的积分导致的积分值变得大于第二阈值时，确定车辆的驱动轮处于滑动状态。

公开(公告)号：US07385035B2

公开(公告)日：2008-06-10

申请号：US10496384

申请日：2002-12-05

申请人： Hiroyuki Ohno ,  Hiromitsu Saisho ,  Hideki Tanzawa

发明人： Hiroyuki Ohno ,  Hiromitsu Saisho ,  Hideki Tanzawa

IPC分类号： C07K5/10

CPC分类号： C07K14/205 ,  A61K38/164 ,  C07K16/121 ,  C12P21/02 ,  G01N2333/205 ,  Y10S435/81

摘要： This invention relates to a new cytotoxic protein (M toxin, mucous layer devastating toxin) produced by Helicobacter pylori and the use.This invention provides a cytotoxic protein (M toxin) produced by Helicobacter pylori, a partial peptide, and an antitumor agent containing the cytotoxic protein. The protein is obtained by culturing a transformant which is transformed with a recombination vector containing DNA coding the cytotoxin protein. This invention provides further the use of the protein.

摘要翻译： 本发明涉及由幽门螺杆菌产生的新的细胞毒素蛋白（M毒素，粘液层破坏性毒素）及其用途。 本发明提供由幽门螺杆菌，部分肽和含有细胞毒性蛋白质的抗肿瘤剂产生的细胞毒性蛋白（M毒素）。 通过培养用含有编码细胞毒素蛋白的DNA的重组载体转化的转化体获得蛋白质。 本发明进一步提供了蛋白质的用途。

公开(公告)号：US07176240B2

公开(公告)日：2007-02-13

申请号：US10194247

申请日：2002-07-15

申请人： Shuichi Ohuchida ,  Kazuo Kishimoto ,  Narito Tateishi ,  Hiroyuki Ohno

发明人： Shuichi Ohuchida ,  Kazuo Kishimoto ,  Narito Tateishi ,  Hiroyuki Ohno

IPC分类号： A01N37/00 ,  A61K31/20 ,  A61K31/19 ,  A61K31/231 ,  C07C63/04

CPC分类号： C07D213/75 ,  A61K31/19 ,  C07C53/21 ,  C07C69/612 ,  C07C69/63 ,  C07C69/708 ,  C07C233/05 ,  C07C233/11 ,  C07C233/25 ,  C07C233/47 ,  C07C233/54 ,  C07C323/52 ,  C07D295/185

摘要： The compound of the formula (I): wherein R1 is alkyl substituted by fluorine(s); R2 is hydroxy, alkoxy, alkoxy substituted by phenyl, NR3R4, in which R3, R4 is (i) hydrogen, (ii) alkyl, (iii) phenyl, (iv) phenyl substituted by alkoxy or carboxyl, (v) heterocyclic ring containing nitrogen atom, (vi) alkyl substituted by phenyl, phenyl substituted by alkoxy or carboxyl, heterocyclic ring containing nitrogen atom, (vii) the nitrogen bonded to R3 and R4, taken together a saturated heterocyclic ring or amino acid residues; and non-toxic salts thereof and acid addition salts thereof. The compounds of the present invention of the formula (I) and the compounds of the formula (X): wherein n is 0 or 1, R11 is hydrogen and chlorine, R5 is R7—CH2— or R8, or R5 and R11, taken together is alkylidene; R6 is hydroxy, alkoxy, alkoxy substituted by phenyl, NR9R10, in which R9, R10 is (i) hydrogen, (ii) alkyl, (iii) phenyl, (iv) phenyl substituted by alkoxy or carboxyl, (v) heterocyclic ring containing nitrogen atom, (vi) alkyl substituted by phenyl, phenyl-substituted by alkoxy or carboxyl, heterocyclic ring containing nitrogen atom, (vii) the nitrogen bonded to R9 and R10, taken together a saturated heterocyclic ring or amino acid residues, R7 is (i) F—(CH2)m— or F3C—CH2—, (ii) alkyl substituted by chlorine, (iii) alkyl substituted by alkoxy, cycloalkyl, phenyl, phenoxy; R8 is alkyl, alkenyl, alkoxy, alkylthio, cycloalkyl, phenyl, phenoxy; non-toxic salts and acid addition salts thereof are useful for prevention and/or treatment for neurodegenerarive disease (Alzheimer's disease etc.) and neuronal dysfunction by stroke or traumic injury (Multiple sclerosis etc.) etc.

公开(公告)号：US20060210575A1

公开(公告)日：2006-09-21

申请号：US10496384

申请日：2002-12-05

申请人： Hiroyuki Ohno ,  Hiromitsu Saisho ,  Hideki Tanzawa

发明人： Hiroyuki Ohno ,  Hiromitsu Saisho ,  Hideki Tanzawa

IPC分类号： G01N33/53 ,  A61K39/395 ,  A61K39/00 ,  C07K14/47

CPC分类号： C07K14/205 ,  A61K38/164 ,  C07K16/121 ,  C12P21/02 ,  G01N2333/205 ,  Y10S435/81

摘要： This invention relates to a new cytotoxic protein (M toxin, mucous layer devastating toxin) produced by Helicobacter pylori and the use. This invention provides a cytotoxic protein (M toxin) produced by Helicobacter pylori, a partial peptide, and an antitumor agent containing the cytotoxic protein. The protein is obtained by culturing a transformant which is transformed with a recombination vector containing DNA coding the cytotoxin protein. This invention provides further the use of the protein.

摘要翻译： 本发明涉及由幽门螺杆菌产生的新的细胞毒素蛋白（M毒素，粘液层破坏性毒素）及其用途。 本发明提供由幽门螺杆菌，部分肽和含有细胞毒性蛋白质的抗肿瘤剂产生的细胞毒性蛋白（M毒素）。 通过培养用含有编码细胞毒素蛋白的DNA的重组载体转化的转化体获得蛋白质。 本发明进一步提供了蛋白质的用途。

公开(公告)号：US6048639A

公开(公告)日：2000-04-11

申请号：US232655

申请日：1999-01-19

申请人： Tsutomu Sonozaki ,  Hiroyuki Ohno ,  Ikuro Nakane ,  Satoshi Narukawa

发明人： Tsutomu Sonozaki ,  Hiroyuki Ohno ,  Ikuro Nakane ,  Satoshi Narukawa

IPC分类号： H01M2/02 ,  H01M10/04 ,  H01M6/00 ,  H01M2/00

CPC分类号： H01M10/0436 ,  H01M2/021 ,  H01M2/0275 ,  H01M10/0525 ,  H01M2/0287

摘要： In a thin type sealed cell utilizing a cell case made of a laminated material, a storage life and reliability of the cell is increased by preventing a sectional surface at an end of the laminated material from being exposed in the cell case, and thereby a leakage of an electrolyte out of the cell and a short circuit in the cell are avoided. This is achieved by disposing a resin layer on the inner surface of the cell case composed of a sheet type laminated material, and covering the sectional surface existing inside the cell case with resin.

摘要翻译： 在使用由层压材料制成的电池壳体的薄型密封电池中，通过防止层叠材料的端部的截面被暴露在电池壳体中，从而提高电池的储存寿命和可靠性，从而泄漏 的电解液，并避免了电池中的短路。 这是通过在由片状层压材料构成的电池壳体的内表面上设置树脂层，并且用树脂覆盖存在于电池壳体内的截面来实现的。

公开(公告)号：US5712391A

公开(公告)日：1998-01-27

申请号：US671001

申请日：1996-06-28

申请人： Hiroyuki Ohno ,  Natsue Kawahara ,  Isaburo Amano ,  Takanao Suzuki ,  Koji Chiba

发明人： Hiroyuki Ohno ,  Natsue Kawahara ,  Isaburo Amano ,  Takanao Suzuki ,  Koji Chiba

IPC分类号： A61K8/895 ,  A61K8/898 ,  A61K47/34 ,  A61Q1/00 ,  A61Q19/00 ,  C08G77/388 ,  C07D251/00 ,  C07D251/40 ,  C07D251/54 ,  C07F7/04

CPC分类号： A61K8/898 ,  A61K47/34 ,  A61Q19/00 ,  C08G77/388 ,  A61K2800/57

摘要： Disclosed are amino silicone derivatives having triazinyl groups or pyrimidinyl groups bound to amino groups of amino silicones, their production and use, said silicone derivatives being able to gel silicone oil or to increase the viscosity thereof stably and homogeneously, and therefore being useful as bases for cosmetics, pharmaceutical preparations and industrial materials.

公开(公告)号：US5411974A

公开(公告)日：1995-05-02

申请号：US265734

申请日：1994-06-27

申请人： Masaaki Toda ,  Shuichi Ohuchida ,  Hiroyuki Ohno

发明人： Masaaki Toda ,  Shuichi Ohuchida ,  Hiroyuki Ohno

IPC分类号： C07D207/08 ,  C07D277/04 ,  C07D405/04 ,  C07D417/06 ,  A61K31/425

CPC分类号： C07D207/08 ,  C07D277/04 ,  C07D405/04 ,  C07D417/06

摘要： Heterocyclic compounds of the general formula: ##STR1## wherein, Z represents methylene group or sulfur atom, R represents a general formula:G--E--D--B--A--.

摘要翻译： 具有以下通式的杂环化合物：其中Z表示亚甲基或硫原子，R表示通式：G-E-D-B-A-。

公开(公告)号：US5340832A

公开(公告)日：1994-08-23

申请号：US107314

申请日：1993-08-17

申请人： Masaaki Toda ,  Shuichi Ohuchida ,  Hiroyuki Ohno

发明人： Masaaki Toda ,  Shuichi Ohuchida ,  Hiroyuki Ohno

IPC分类号： A61K31/40 ,  A61K31/401 ,  A61K31/4025 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61P25/28 ,  C07D207/08 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  A61K31/52

CPC分类号： C07D207/08 ,  C07D405/12

摘要： A novel prolinal derivative of the general formula: ##STR1## [wherein A represents alkylene or alkenylene group of from 1 to 8 carbon atom(s) or a saturated hydrocarbon ring of from 3 to 7 carbon atoms, R represents hydrogen atom, phenyl group, benzyl group, alkyl group of from 1 to 8 carbon atom(s) or cycloalkyl group of from 3 to 7 carbon atoms,B represents alkylene group of from 1 to 8 atom(s) unsubstituted or substituted by phenyl group or benzyl group, or a single bond,D represents carbocyclic or heterocyclic ring unsubstituted or substituted by from one to three of halogen atom, alkyl or alkoxy group of from 1 to 4 carbon atom(s), nitro group or trifluoromethyl group.]possess inhibitory activity on prolyl endopeptidase, and therefore are useful for treating and/or preventing agent as a amnesia.

摘要翻译： 一种新颖的通式如下的流延衍生物：其中A表示1至8个碳原子的亚烷基或亚烯基或3至7个碳原子的饱和烃环，R表示氢原子 苯基，苄基，1〜8个碳原子的烷基或3〜7个碳原子的环烷基，B表示1〜8个未被取代或被苯基取代或被苯基取代的亚烷基， 苄基或单键，D表示未被取代或被1至3个卤素原子，1至4个碳原子的烷基或烷氧基，硝基或三氟甲基取代的碳环或杂环。]具有抑制性 对脯氨酰内肽酶的活性，因此可用于治疗和/或预防药物作为遗忘。

公开(公告)号：US5254550A

公开(公告)日：1993-10-19

申请号：US803421

申请日：1991-12-06

申请人： Masaaki Toda ,  Shuichi Ohuchida ,  Hiroyuki Ohno

发明人： Masaaki Toda ,  Shuichi Ohuchida ,  Hiroyuki Ohno

IPC分类号： C07D207/08 ,  C07D405/12 ,  A61K31/495 ,  C07D401/12

CPC分类号： C07D207/08 ,  C07D405/12

摘要： A novel prolinal derivative of the general formula: ##STR1## [wherein A represents alkylene or alkenylene group of from 1 to 8 carbon atom(s) or a saturated hydrocarbon ring of from 3 to 7 carbon atoms,R represents hydrogen atom, phenyl group, benzyl group, alkyl group of from 1 to 8 carbon atom(s) or cycloalkyl group of from 3 to 7 carbon atoms,B represents alkylene group of from 1 to 8 atom(s) unsubstituted or substituted by phenyl group or benzyl group, or a single bond,D represents carbocyclic or heterocyclic ring unsubstituted or substituted by from one to three of halogen atom, alkyl or alkoxy group of from 1 to 4 carbon atom(s), nitro group or trifluoromethyl group]posses inhibitory activity on prolyl endopeptidase, and therefore are useful for treating and/or preventing agent for amnesia.

摘要翻译： 一种新颖的通式如下的流延衍生物：其中A表示1至8个碳原子的亚烷基或亚烯基或3至7个碳原子的饱和烃环，R表示氢原子 苯基，苄基，1〜8个碳原子的烷基或3〜7个碳原子的环烷基，B表示1〜8个未被取代或被苯基取代或被苯基取代的亚烷基， 苄基或单键，D表示未被取代或被1至3个卤素原子，1至4个碳原子的烷基或烷氧基，硝基或三氟甲基取代的碳环或杂环]具有抑制活性 在脯氨酰内肽酶上，因此可用于治疗和/或预防健忘症药物。