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公开(公告)号:US20080044413A1
公开(公告)日:2008-02-21
申请号:US11645290
申请日:2006-12-21
申请人: Scott Hammond , Peter Kiener , Elizabeth Bruckheimer , Michael Kinch , Shannon Roff , Ralf Lutterbuese , Petra Lutterbuese , Bernd Schlereth , Patrick Baeuerle , Peter Kufer
发明人: Scott Hammond , Peter Kiener , Elizabeth Bruckheimer , Michael Kinch , Shannon Roff , Ralf Lutterbuese , Petra Lutterbuese , Bernd Schlereth , Patrick Baeuerle , Peter Kufer
IPC分类号: A61K39/395 , A61P31/00 , A61P35/00 , A61P43/00 , C07K16/28
CPC分类号: C07K16/2866 , C07K16/2809 , C07K16/30 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , C07K2319/30
摘要: The present invention relates to bispecific single chain antibodies comprising a first binding domain that immunospecifically binds to the T-cell antigen CD3 and a second binding domain that immunospecifically binds to the EphA2 receptor. Such bispecific single chain antibodies are encompassed by the term “EphA2-BiTEs.” The present invention further relates to methods and compositions designed for the treatment, prevention and/or management of disorders associated with aberrant expression and/or activity of EphA2. Such disorders include, but are not limited to, cancer, non-cancer hyperproliferative cell disorders, and infections. The invention further relates to vectors comprising polynucleotides encoding the EphA2-BiTEs of the invention, host cells transformed therewith, and their use in the production of said EphA2-BiTEs. The invention also provides compositions, including pharmaceutical compositions, comprising any of the aforementioned EphA2-BiTEs, polynucleotides or vectors either alone or in combination with one or more prophylactic or therapeutic agents. Also disclosed are methods of screening for said EphA2-BiTEs and kits comprising any of the aforementioned compositions and diagnostic reagents.
摘要翻译: 本发明涉及双特异性单链抗体,其包含免疫特异性结合T细胞抗原CD3的第一结合结构域和免疫特异性结合EphA2受体的第二结合结构域。 这种双特异性单链抗体包括在术语“EphA2-BiTEs”中。 本发明还涉及设计用于治疗,预防和/或控制与EphA2的异常表达和/或活性相关的病症的方法和组合物。 这些疾病包括但不限于癌症,非癌症过度增殖性细胞病症和感染。 本发明还涉及包含编码本发明的EphA2-BiTE的多核苷酸,转化的宿主细胞的载体及其在所述EphA2-BiTE的生产中的用途。 本发明还提供包含单独或与一种或多种预防或治疗剂组合的任何上述EphA2-BiTE,多核苷酸或载体的组合物,包括药物组合物。 还公开了筛选所述EphA2-BiTE和包含任何上述组合物和诊断试剂的试剂盒的方法。
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公开(公告)号:US20100183615A1
公开(公告)日:2010-07-22
申请号:US12594729
申请日:2008-04-03
申请人: Peter Kufer , Tobias Raum , Roman Kischel , Ralf Lutterbuese , Patrick Hoffmann , Matthias Klinger , Doris Rau , Susanne Mangold
发明人: Peter Kufer , Tobias Raum , Roman Kischel , Ralf Lutterbuese , Patrick Hoffmann , Matthias Klinger , Doris Rau , Susanne Mangold
CPC分类号: C07K16/2809 , C07K16/2863 , C07K16/30 , C07K16/3053 , C07K16/32 , C07K16/40 , C07K16/4291 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/73 , C07K2317/90 , C07K2317/92 , C07K2319/32 , C07K2319/43
摘要: The present invention relates to a polypeptide comprising a first human binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 (epsilon) chain and a second binding domain capable of binding to EGFR, Her2/neu or IgE of a human and/or a non-chimpanzee primate as well as to a process for the production of the mentioned polypeptide. The invention further relates to nucleic acids encoding for the polypeptide, to vectors comprising the same and to host cells comprising the vector. In another aspect, the invention provides for a pharmaceutical composition comprising the mentioned polypeptide and medical uses of the polypeptide.
摘要翻译: 本发明涉及包含能够结合人和非黑猩猩灵长类CD3(ε)链的表位的第一人结合结构域和能够结合人的EGFR,Her2 / neu或IgE的第二结合结构域的多肽 和/或非黑猩猩灵长类动物以及生产所述多肽的方法。 本发明还涉及编码多肽的核酸,包含其的载体和包含载体的宿主细胞。 另一方面,本发明提供包含所述多肽的药物组合物和多肽的医学用途。
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3.
公开(公告)号:US20130129730A1
公开(公告)日:2013-05-23
申请号:US13638223
申请日:2011-04-01
申请人: Peter Kufer , Ralf Lutterbuese , Matthias Klinger , Petra Fluhr , Doris Rau , Susanne Hausmann , Carole Steiger , Tobias Raum , Patrick Hoffmann , Roman Kischel , Evelyne Schaller , Susanne Mangold
发明人: Peter Kufer , Ralf Lutterbuese , Matthias Klinger , Petra Fluhr , Doris Rau , Susanne Hausmann , Carole Steiger , Tobias Raum , Patrick Hoffmann , Roman Kischel , Evelyne Schaller , Susanne Mangold
IPC分类号: C07K16/46
CPC分类号: C07K16/468 , C07K16/2809 , C07K16/30 , C07K16/3069 , C07K2317/31 , C07K2317/33 , C07K2317/622
摘要: The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain capable of binding to prostate-specific membrane antigen (PSMA). The invention also provides nucleic acids encoding said bispecific single chain antibody molecule as well as vectors and host cells and a process for its production. The invention further relates to pharmaceutical compositions comprising said bispecific single chain antibody molecule and medical uses of said bispecific single chain antibody molecule.
摘要翻译: 本发明涉及双特异性单链抗体分子,其包含能够结合人和非黑猩猩灵长类CD3ε链的表位的第一结合结构域,其中所述表位是包含在SEQ ID NO:1中的氨基酸序列的一部分 身份证号 2,4,6和8以及能够结合前列腺特异性膜抗原(PSMA)的第二结合结构域。 本发明还提供了编码所述双特异性单链抗体分子以及载体和宿主细胞的核酸及其生产方法。 本发明还涉及包含所述双特异性单链抗体分子的药物组合物和所述双特异性单链抗体分子的医学应用。
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公开(公告)号:US20100150918A1
公开(公告)日:2010-06-17
申请号:US12594713
申请日:2008-04-03
申请人: Peter Kufer , Tobias Raum , Roman Kischel , Ralf Lutterbuese , Patrick Hoffmann , Matthias Klinger , Doris Rau , Susanne Mangold
发明人: Peter Kufer , Tobias Raum , Roman Kischel , Ralf Lutterbuese , Patrick Hoffmann , Matthias Klinger , Doris Rau , Susanne Mangold
CPC分类号: C07K16/082 , A61K2039/505 , C07K14/7051 , C07K16/109 , C07K16/28 , C07K16/2809 , C07K16/2863 , C07K16/2878 , C07K16/2884 , C07K16/30 , C07K16/3053 , C07K16/32 , C07K16/4291 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2319/30 , C07K2319/40
摘要: The present invention relates to a polypeptide comprising a human binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 (epsilon) chain as well as to a process for the production of the mentioned polypeptide. The invention further relates to nucleic acids encoding for the polypeptide, to vectors comprising the same and to host cells comprising the vector. In another aspect, the invention provides for a pharmaceutical composition comprising the mentioned polypeptide and medical uses of the polypeptide. In a further aspect the invention provides a method for the identification of polypeptides comprising a cross-species specific binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3ε (CD3 epsilon).
摘要翻译: 本发明涉及包含能够结合人和非黑猩猩灵长类CD3(ε)链的表位的人结合结构域的多肽以及生产所述多肽的方法。 本发明还涉及编码多肽的核酸,包含其的载体和包含载体的宿主细胞。 另一方面,本发明提供包含所述多肽的药物组合物和多肽的医学用途。 在另一方面,本发明提供了用于鉴定多肽的方法,所述多肽包含能够结合人和非黑猩猩灵长类CD3抗原决定簇的物种间特异性结合结构域; (CD3ε)。
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5.
公开(公告)号:US09587036B2
公开(公告)日:2017-03-07
申请号:US13638223
申请日:2011-04-01
申请人: Peter Kufer , Ralf Lutterbuese , Matthias Klinger , Petra Fluhr , Doris Rau , Susanne Hausmann , Carola Steiger , Tobias Raum , Patrick Hoffmann , Roman Kischel , Evelyne Schaller , Susanne Mangold
发明人: Peter Kufer , Ralf Lutterbuese , Matthias Klinger , Petra Fluhr , Doris Rau , Susanne Hausmann , Carola Steiger , Tobias Raum , Patrick Hoffmann , Roman Kischel , Evelyne Schaller , Susanne Mangold
IPC分类号: C07K16/46 , A61K39/395 , C07K16/28 , C07K16/30
CPC分类号: C07K16/468 , C07K16/2809 , C07K16/30 , C07K16/3069 , C07K2317/31 , C07K2317/33 , C07K2317/622
摘要: The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain capable of binding to prostate-specific membrane antigen (PSMA). The invention also provides nucleic acids encoding said bispecific single chain antibody molecule as well as vectors and host cells and a process for its production. The invention further relates to pharmaceutical compositions comprising said bispecific single chain antibody molecule and medical uses of said bispecific single chain antibody molecule.
摘要翻译: 本发明涉及双特异性单链抗体分子,其包含能够结合人和非黑猩猩灵长类CD3ε链的表位的第一结合结构域,其中所述表位是包含在SEQ ID NO:1中的氨基酸序列的一部分 身份证号 2,4,6和8以及能够结合前列腺特异性膜抗原(PSMA)的第二结合结构域。 本发明还提供了编码所述双特异性单链抗体分子以及载体和宿主细胞的核酸及其生产方法。 本发明还涉及包含所述双特异性单链抗体分子的药物组合物和所述双特异性单链抗体分子的医学应用。
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