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公开(公告)号:US5231196A
公开(公告)日:1993-07-27
申请号:US627637
申请日:1990-12-14
CPC分类号: C07D213/30 , C07C43/21 , C07C2103/92
摘要: The present invention relates to an improvement in the process for preparing a calixarene derivative in which the rotation of its benzene units are hindered and which comprises replacing all or a part of the hydrogen atoms of the hydroxyl groups of a calixarene derivative represented by the general formula: ##STR1## and is characterized by conducting the reaction in the presence of an alkaline earth metal. According to the present invention, an asymmetric calixarene derivative having a "cone" conformation can be selectively prepared by virtue of the template effect of the metal.
摘要翻译: 本发明涉及制备其苯单元旋转受阻的杯芳烃衍生物的制备方法的改进,其包括用通式(I)表示的杯芳烃衍生物的羟基的全部或一部分代替 :
,其特征在于在碱土金属存在下进行反应。 根据本发明,可以通过金属的模板效应选择性地制备具有“锥形”构型的不对称杯芳烃衍生物。