公开(公告)号：US20100235377A1

公开(公告)日：2010-09-16

申请号：US12401522

申请日：2009-03-10

申请人： Sergly V. Kuryata ,  Michael J. McLaughlin ,  Brian J. Smith ,  Steven J. Pratschner ,  Ramesha Chandrashekhar

发明人： Sergly V. Kuryata ,  Michael J. McLaughlin ,  Brian J. Smith ,  Steven J. Pratschner ,  Ramesha Chandrashekhar

IPC分类号： G06F17/30 ,  G06F15/16 ,  G06F9/45

CPC分类号： G06F9/45516 ,  G06F12/0253

摘要： Just in time compiled code and other data within a runtime environment may be shared between multiple applications by identifying common data objects and allowing two or more applications to access the data objects. While at least one application is accessing the objects, the objects may remain in memory. When all applications have stopped accessing an object, the object may be removed from memory. One embodiment may use a server process to manage various operations to facilitate sharing between various applications, such as identifying objects that may be removed from memory and adding newly created data to a database of sharable data.

摘要翻译： 通过识别公共数据对象并允许两个或更多个应用程序访问数据对象，可以在运行时环境中编译代码和其他数据可以在多个应用程序之间共享。 当至少一个应用程序正在访问对象时，对象可能会保留在内存中。 当所有应用程序都停止访问对象时，对象可能会从内存中删除。 一个实施例可以使用服务器进程来管理各种操作以促进各种应用之间的共享，诸如识别可以从存储器移除的对象并将新创建的数据添加到可共享数据的数据库。

公开(公告)号：US08156093B2

公开(公告)日：2012-04-10

申请号：US12401522

申请日：2009-03-10

申请人： Sergiy V. Kuryata ,  Michael J. McLaughlin ,  Brian J. Smith ,  Steven J. Pratschner ,  Ramesha Chandrashekhar

发明人： Sergiy V. Kuryata ,  Michael J. McLaughlin ,  Brian J. Smith ,  Steven J. Pratschner ,  Ramesha Chandrashekhar

IPC分类号： G06F17/30

CPC分类号： G06F9/45516 ,  G06F12/0253

摘要： Just in time compiled code and other data within a runtime environment may be shared between multiple applications by identifying common data objects and allowing two or more applications to access the data objects. While at least one application is accessing the objects, the objects may remain in memory. When all applications have stopped accessing an object, the object may be removed from memory. One embodiment may use a server process to manage various operations to facilitate sharing between various applications, such as identifying objects that may be removed from memory and adding newly created data to a database of sharable data.

摘要翻译： 通过识别公共数据对象并允许两个或更多个应用程序访问数据对象，可以在运行时环境中编译代码和其他数据可以在多个应用程序之间共享。 当至少一个应用程序正在访问对象时，对象可能会保留在内存中。 当所有应用程序都停止访问对象时，对象可能会从内存中删除。 一个实施例可以使用服务器进程来管理各种操作以促进各种应用之间的共享，诸如识别可以从存储器移除的对象并将新创建的数据添加到可共享数据的数据库。

公开(公告)号：US09463178B2

公开(公告)日：2016-10-11

申请号：US14809881

申请日：2015-07-27

申请人： Brian J. Smith

发明人： Brian J. Smith

IPC分类号： A61K31/12 ,  A61K31/216 ,  A61K31/4184 ,  A61K47/24 ,  A61K31/277 ,  A61K31/618 ,  A61K45/06 ,  A61K9/00 ,  A61K31/675 ,  A61K47/10 ,  A61K47/26

CPC分类号： A61K31/216 ,  A61K9/0048 ,  A61K31/12 ,  A61K31/277 ,  A61K31/4184 ,  A61K31/618 ,  A61K31/675 ,  A61K45/06 ,  A61K47/10 ,  A61K47/24 ,  A61K47/26 ,  A61K2300/00

摘要： An ophthalmic solution is provided. The ophthalmic solution includes an ultraviolet-A absorber and an ultraviolet-B absorber. The ophthalmic solution has a viscosity of between about 1 and 100 cps. The ophthalmic solution can be used to absorb ultraviolet radiation in the eye.

公开(公告)号：US20140269327A1

公开(公告)日：2014-09-18

申请号：US13846575

申请日：2013-03-18

申请人： John C. Fulknier ,  Brian J. Smith

发明人： John C. Fulknier ,  Brian J. Smith

IPC分类号： H04W28/02

CPC分类号： H04L47/125 ,  H04L41/00 ,  H04W28/0205 ,  H04W40/18

摘要： A mobile network configuration 800 includes a plurality of mobile computing devices B, C, D each operating one or more cellular network interfaces to connect with one or more cellular networks 805 that provide a gateway 815 to a Wide Area Network (WAN) 515. Each mobile computing device B, C, D routes substantially all network traffic exiting from the mobile computing device to a network controller 520 deployed on or reachable over the WAN 515. The network controller 520 routes incoming exit data packets to a final destination IP address read from each exit data packet and causes any reply data packets responsive to the exit data packets to be routed back to the network controller 520. The reply data packets are then routed back to the appropriate mobile computing device. When multiple communication links 810 are available network traffic is divided over the available links 810.

摘要翻译： 移动网络配置800包括多个移动计算设备B，C，D，每个移动计算设备操作一个或多个蜂窝网络接口以与向广域网（WAN）515提供网关815的一个或多个蜂窝网络805连接。每个 移动计算设备B，C，D基本上将从移动计算设备退出的所​​有网络流量路由到部署在WAN 515上或可通过WAN 515连接的网络控制器520.网络控制器520将进入的退出数据分组路由到从 每个出口数据分组并且使得响应于退出数据分组的任何应答数据分组被路由回到网络控制器520.然后将答复数据分组路由回适当的移动计算设备。 当多个通信链路810可用时，可用链路810划分网络流量。

公开(公告)号：US20130324992A1

公开(公告)日：2013-12-05

申请号：US13484586

申请日：2012-05-31

申请人： Ronald Bush ,  Brian J. Smith ,  Anthony Johnson

发明人： Ronald Bush ,  Brian J. Smith ,  Anthony Johnson

IPC分类号： A61B18/18

CPC分类号： A61B18/1477 ,  A61B2017/00526 ,  A61B2018/00083 ,  A61B2018/00107 ,  A61B2018/00404

摘要： A radio frequency sclerotherapy system includes a needle assembly with a thin (26 to 32 gauge) solid conductive needle, about 1.25 inches long. A multilayer coating is applied over a proximal portion of the needle leaving an uncoated distal tip, about 0.10 inches long, exposed. The multilayer coating is an electric and thermal insulator. An electrical plug electrically coupled to the proximal end of the wire. The multilayer coating provides a palpable transition. A generator supplies voltages in the range of 300V to −100V, at frequencies of 1 MHz to 50 MHz, with voltage spikes having a time from rise to fall of up to 100 nS and a low voltage between voltage spikes for about twice the duration of the time from rise to fall of the voltage spikes.

摘要翻译： 射频硬化治疗系统包括具有约1.25英寸长的薄（26至32号）固体导电针的针组件。 将多层涂层施加在针的近端部分上，留下约0.10英寸长的未涂覆的远端，露出。 多层涂层是电绝缘体和热绝缘体。 电连接到电线的近端的电插头。 多层涂层提供了明显的转变。 发电机以1MHz至50MHz的频率提供300V至-100V范围内的电压，电压尖峰时间从上升到下降至100nS，电压尖峰之间的低电压约为持续时间的两倍 时间从上升到下降的电压尖峰。

公开(公告)号：US20130286945A1

公开(公告)日：2013-10-31

申请号：US13927033

申请日：2013-06-25

申请人： John Fulknier ,  Brian J. Smith

发明人： John Fulknier ,  Brian J. Smith

IPC分类号： H04W40/00

CPC分类号： H04W40/00 ,  H04L45/00 ,  H04L45/60 ,  H04W4/80 ,  H04W24/08 ,  H04W28/08 ,  H04W48/18 ,  H04W76/15 ,  H04W84/12 ,  H04W84/18 ,  H04W88/10 ,  H04W88/16

摘要： A wireless mobile router (140) includes wireless network interfaces (202) and (218) attached to a network controller (142). The wireless network interface (202) communicates with a cellular network (110) to access cellular network services. The wireless network interface (218) and the network controller (142) comprise a WLAN (170) or PAN (180) and a network router hosting a plurality of client devices. Each client device may access a wide area network, WAN over the cellular network. The wireless mobile router (140) is configured to exchange various cellular network signals with various WLAN and PAN networks. The wireless mobile router (140) is particularly suitable for use in a vehicle or at locations where WAN access is not readily available.

摘要翻译： 无线移动路由器（140）包括附接到网络控制器（142）的无线网络接口（202）和（218）。 无线网络接口（202）与蜂窝网络（110）通信以接入蜂窝网络服务。 无线网络接口（218）和网络控制器（142）包括WLAN（170）或PAN（180）和托管多个客户端设备的网络路由器。 每个客户端设备可以通过蜂窝网络访问广域网WAN。 无线移动路由器（140）被配置为与各种WLAN和PAN网络交换各种蜂窝网络信号。 无线移动路由器（140）特别适用于车辆或WAN接入不容易获得的位置。

公开(公告)号：US20080027145A1

公开(公告)日：2008-01-31

申请号：US10588687

申请日：2005-02-03

申请人： David C. S. Huang ,  Peter M. Colman ,  Catherine L. Day ,  Jerry M. Adams ,  Lin Chen ,  Simon N. Willis ,  Andrew Wei ,  Brian J. Smith ,  Mark G. Hinds

发明人： David C. S. Huang ,  Peter M. Colman ,  Catherine L. Day ,  Jerry M. Adams ,  Lin Chen ,  Simon N. Willis ,  Andrew Wei ,  Brian J. Smith ,  Mark G. Hinds

IPC分类号： A61K35/00 ,  A61P35/00 ,  G01N33/48 ,  G01N33/53

CPC分类号： C07K14/4747

摘要： The present invention relates generally to therapeutic molecules useful for inducing apoptosis of particular cells such as, but not limited to, cancer cells and methods for generating and/or selecting same. The present invention further provides methods for inducing apoptosis of cells such as cancer cells and pharmaceutical compositions useful for same. The present invention further provides methods for generating or selecting therapeutic agents capable of inducing apoptosis of particular cells by the selective inhibition of pro-survival proteins. The present invention further provides a computational approach to therapeutic molecule design based on structure-binding characteristics.

摘要翻译： 本发明一般涉及用于诱导特定细胞凋亡的治疗分子，所述特定细胞例如但不限于癌细胞，以及用于产生和/或选择癌细胞的方法。 本发明还提供诱导细胞凋亡的方法，例如癌细胞和对其有用的药物组合物。 本发明还提供了通过选择性抑制前体存活蛋白来产生或选择能够诱导特定细胞凋亡的治疗剂的方法。 本发明还提供了基于结构结合特征的治疗分子设计的计算方法。

公开(公告)号：US07269829B2

公开(公告)日：2007-09-11

申请号：US10902034

申请日：2004-07-30

申请人： Brian J. Smith ,  Eric Schafer

发明人： Brian J. Smith ,  Eric Schafer

IPC分类号： G05D11/00 ,  G05D7/00 ,  G06F9/44 ,  G06F3/00 ,  G06F15/167

CPC分类号： G05B19/0426 ,  G05B2219/23304 ,  G05B2219/2625

摘要： A remote download of microprocessor code for an irrigation controller is provided. A microprocessor, on an irrigation controller, is executing program code (in volatile memory) and receives a remote download of updated program code, which it stores into non-volatile random access memory, e.g., flash memory. The microprocessor is configured to receive the updated program code, via a communication port, and to store the updated program code into the non-volatile flash memory. Optionally, the updated program code is received at multiple controllers via a global transmission on a communication bus. The microprocessor receives a communication causing it to re-start. In response to the re-start communication, the microprocessor fetches the updated program code stored in the non-volatile flash memory into the program memory RAM to replace the original program code, and begins execution of the updated program code in the program memory RAM. A device is also provided for directing the download of program code to irrigation controllers. Options provide for global download of entirely new program code, global and/or individual download of particular pages of updated program code, and global downloads to controllers grouped by communication speed.

摘要翻译： 提供远程下载用于灌溉控制器的微处理器代码。 灌溉控制器上的微处理器正在执行程序代码（在易失性存储器中）并且接收更新的程序代码的远程下载，其被存储到非易失性随机存取存储器，例如闪速存储器中。 微处理器被配置为经由通信端口接收更新的程序代码，并将更新的程序代码存储到非易失性闪存中。 可选地，更新的程序代码经由通信总线上的全局传输在多个控制器处被接收。 微处理器接收到使其重新启动的通信。 响应于重新启动通信，微处理器将存储在非易失性闪速存储器中的更新的程序代码取回到程序存储器RAM中以替换原始程序代码，并开始执行程序存储器RAM中更新的程序代码。 还提供了用于将程序代码下载到灌溉控制器的装置。 选项提供全球下载全新程序代码，全球和/或个别下载更新程序代码的特定页面，以及通过通信速度分组的控制器的全局下载。

公开(公告)号：US07250860B2

公开(公告)日：2007-07-31

申请号：US10952821

申请日：2004-09-30

申请人： Brian J. Smith ,  Eric Schafer

发明人： Brian J. Smith ,  Eric Schafer

IPC分类号： G08B1/08

CPC分类号： H04M3/42144 ,  H04M3/42348 ,  H04M2201/14 ,  H04M2201/30

摘要： A controller (301), for example on a field interface of a resource management system (300), determines a location of a mobile object (303a, 303b, 303c) and controls an environment thereof. The controller (301) receives, via a first transceiver (307), a communication including information representative of the mobile object; receives a command via a second transceiver (317) and controls the environment outside of the mobile object responsive to the command and/or the communication. A controller, for example on the mobile object (303a, 303b, 303c), detects a location of the mobile object (303a, 303b, 303c) via device (305a, 305b, 305c). The controller collects information about the mobile object including location; transmits, to a controller via its transceiver, a communication including the information; receives a command via its transceiver; and controls operation of the mobile object responsive to the command.

摘要翻译： 控制器（301）例如在资源管理系统（300）的现场接口上确定移动对象（303a，303b，303c）的位置并控制其环境。 控制器（301）经由第一收发器（307）接收包括表示移动对象的信息的通信; 经由第二收发器（317）接收命令，并响应于该命令和/或通信来控制移动对象外的环境。 例如在移动物体（303a，303b，303c）上的控制器经由设备（305a，305b，305c）检测移动物体（303a，303b，303c）的位置。 控制器收集有关移动对象的信息，包括位置; 通过其收发器向控制器发送包括该信息的通信; 通过收发器接收命令; 并响应于该命令来控制移动对象的操作。

公开(公告)号：US06898467B1

公开(公告)日：2005-05-24

申请号：US10627877

申请日：2003-07-28

申请人： Brian J. Smith ,  Eric Schafer

发明人： Brian J. Smith ,  Eric Schafer

IPC分类号： G05B15/02 ,  G05B19/042 ,  G06N5/00

CPC分类号： G05B15/02 ,  G05B19/0421 ,  G05B2219/2229 ,  G05B2219/23043 ,  G05B2219/25187 ,  G05B2219/25192 ,  G05B2219/25232 ,  G05B2219/25428 ,  G05B2219/2625

摘要： A system and method for operating a distributed control network for irrigation management. The system incorporates several irrigation controllers wherein each of the controllers can transmit, receive and respond to commands initiated by any device or satellite controller on the network, a communication bus that is connected to the controllers, a central computer that is connected to the bus, several sensing devices that are connected to each controller, and several sprinkler valves that are connected to each controller. The controllers can be operated in local mode via a user interface and in a remote mode via a wireless connection. The controllers are capable of monitoring and acknowledging the commands that are transmitted on the bus.

摘要翻译： 一种运行灌溉管理分布式控制网络的系统和方法。 该系统包括几个灌溉控制器，其中每个控制器可以发送，接收和响应由网络上的任何设备或卫星控制器发起的命令，连接到控制器的通信总线，连接到总线的中央计算机， 连接到每个控制器的几个感测装置和连接到每个控制器的几个喷洒阀。 控制器可以通过用户界面以远程模式通过无线连接在本地模式下运行。 控制器能够监视和确认在总线上传输的命令。