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公开(公告)号：US11111227B2
公开(公告)日：2021-09-07
申请号：US16860037
申请日：2020-04-27
发明人： Mina Yang , Yongtao Jiang , Ying Meng , Tao Wang , Qian qian Xu , Xin Shao , Chunjie Sha
IPC分类号： C07D333/10
摘要： The present disclosure relates to rotigotine behenate, methods for preparing the same and use of the same for treating diseases associated with dopamine receptor. The rotigotine behenate, the structure of which is shown below, is capable of reducing fluctuation in blood drug concentrations, improving the bioavailability of the drug in vivo, and achieving smooth and extended release of rotigotine.
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公开(公告)号：US20170035856A1
公开(公告)日：2017-02-09
申请号：US15304528
申请日：2015-04-16
发明人： Tao Wang , Qilin Wang , Qianqian Xu , Lifang Sun , Ying Meng , Ju Li
CPC分类号： A61K38/26 , A61K9/16 , A61K9/1647 , A61K9/1682 , A61K38/22 , A61K47/34
摘要： An exenatide-containing composition is in the form of microspheres, which are prepared by using exenatide acetate and polylactic-co-glycolic acid (PLGA) as raw materials, and the content of acetic acid in the prepared composition is lower than 0.01%. A method for preparing the exenatide-containing microspheres includes selecting a cleaning fluid of a proper external water Phase and a proper amount to clean microspheres, and selecting a proper re-drying temperature to cure the after the microspheres are freeze dried.
摘要翻译： 含有艾塞那肽的组合物为微球形式，其通过使用醋酸艾塞那肽和聚乳酸共 - 乙醇酸（PLGA）作为原料制备，并且所制备组合物中乙酸的含量低于0.01％。 制备含有艾塞那肽的微球的方法包括选择适当的外部水相的清洗液和适量的清洁微球，并在微球冷冻干燥后选择适当的再干燥温度以固化。
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公开(公告)号：US10669249B2
公开(公告)日：2020-06-02
申请号：US16309807
申请日：2016-07-21
发明人： Mina Yang , Yongtao Jiang , Ying Meng , Tao Wang , Qian qian Xu , Xin Shao , Chunjie Sha
IPC分类号： C07D333/10
摘要： The present disclosure relates to rotigotine behenate, methods for preparing the same and use of the same for treating diseases associated with dopamine receptor. The rotigotine behenate, the structure of which is shown below, is capable of reducing fluctuation in blood drug concentrations, improving the bioavailability of the drug in vivo, and achieving smooth and extended release of rotigotine.
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公开(公告)号：US20180117123A1
公开(公告)日：2018-05-03
申请号：US15803807
申请日：2017-11-05
发明人： Tao Wang , Qilin Wang , Qianqian Xu , Lifang Sun , Ying Meng , Ju Li
CPC分类号： A61K38/26 , A61K9/16 , A61K9/1647 , A61K9/1682 , A61K38/22 , A61K47/34
摘要： An exenatide-containing composition is in the form of microspheres, which are prepared by using exenatide acetate and polylactic-co-glycolic acid (PLGA) as raw materials, and the content of acetic acid in the prepared composition is lower than 0.01%. A method for preparing the exenatide-containing microspheres includes selecting a cleaning fluid of a proper external water phase and a proper amount to clean microspheres, and selecting a proper re-drying temperature to cure the microspheres after the microspheres are freeze-dried.
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