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公开(公告)号:US08501758B2
公开(公告)日:2013-08-06
申请号:US12870130
申请日:2010-08-27
申请人: Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
发明人: Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
IPC分类号: A01N43/54
CPC分类号: C07D403/04 , A61K9/0053 , A61K31/4184 , A61K31/506 , A61K45/06 , C07D401/14 , C07D405/14 , A61K2300/00
摘要: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
摘要翻译: 本发明提供了一类新颖的化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法,特别是涉及B-Raf异常激活的疾病或病症。
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公开(公告)号:US20110306625A1
公开(公告)日:2011-12-15
申请号:US12870130
申请日:2010-08-27
申请人: Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
发明人: Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
IPC分类号: A61K31/506 , A61P25/24 , A61P1/08 , C07D401/04 , A61P35/00
CPC分类号: C07D403/04 , A61K9/0053 , A61K31/4184 , A61K31/506 , A61K45/06 , C07D401/14 , C07D405/14 , A61K2300/00
摘要: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
摘要翻译: 本发明提供了一类新颖的化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法,特别是涉及B-Raf异常激活的疾病或病症。
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公开(公告)号:US20130296318A1
公开(公告)日:2013-11-07
申请号:US13931111
申请日:2013-06-28
申请人: Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
发明人: Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
IPC分类号: C07D403/04 , C07D401/14 , C07D405/14 , A61K45/06 , A61K31/506
CPC分类号: C07D403/04 , A61K9/0053 , A61K31/4184 , A61K31/506 , A61K45/06 , C07D401/14 , C07D405/14 , A61K2300/00
摘要: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
摘要翻译: 本发明提供了一类新颖的化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法,特别是涉及B-Raf异常激活的疾病或病症。
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公开(公告)号:US20140011825A1
公开(公告)日:2014-01-09
申请号:US14022540
申请日:2013-09-10
申请人: Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew
发明人: Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew
IPC分类号: C07D403/04 , A61K45/06 , A61K31/506
CPC分类号: C07D403/04 , A61K31/506 , A61K45/06
摘要: The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.
摘要翻译: 本发明提供式I或II的化合物:其中R1,R1b,R2,R3,R4,R5,R6和R7如本文所定义。 式(I)或(II)的化合物及其药物组合物可用于治疗B-Raf相关疾病。
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公开(公告)号:US08563553B2
公开(公告)日:2013-10-22
申请号:US13473230
申请日:2012-05-16
申请人: Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew
发明人: Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew
IPC分类号: A61K31/50
CPC分类号: C07D403/04 , A61K31/506 , A61K45/06
摘要: The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.
摘要翻译: 本发明提供式I或II的化合物:其中R1,R1b,R2,R3,R4,R5,R6和R7如本文所定义。 式(I)或(II)的化合物及其药物组合物可用于治疗B-Raf相关疾病。
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公开(公告)号:US08859548B2
公开(公告)日:2014-10-14
申请号:US14022540
申请日:2013-09-10
申请人: Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew , Qiong Zhang
发明人: Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew , Qiong Zhang
IPC分类号: A61K31/50 , A61K45/06 , A61K31/506 , C07D403/04
CPC分类号: C07D403/04 , A61K31/506 , A61K45/06
摘要: The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.
摘要翻译: 本发明提供式I或II的化合物:其中R1,R1b,R2,R3,R4,R5,R6和R7如本文所定义。 式(I)或(II)的化合物及其药物组合物可用于治疗B-Raf相关疾病。
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公开(公告)号:US20110052578A1
公开(公告)日:2011-03-03
申请号:US12862418
申请日:2010-08-24
申请人: Abran Q. Costales , Shenlin Huang , Jeff (Xianming) Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew
发明人: Abran Q. Costales , Shenlin Huang , Jeff (Xianming) Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew
IPC分类号: A61K39/395 , C07D401/04 , A61K31/506 , A61P35/00 , A61P37/00
CPC分类号: C07D403/04 , A61K31/506 , A61K45/06
摘要: The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.
摘要翻译: 本发明提供式I或II的化合物:其中R1,R1b,R2,R3,R4,R5,R6和R7如本文所定义。 式(I)或(II)的化合物及其药物组合物可用于治疗B-Raf相关疾病。
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公开(公告)号:US08242260B2
公开(公告)日:2012-08-14
申请号:US12862418
申请日:2010-08-24
申请人: Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew , Qiong Zhang
发明人: Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew , Qiong Zhang
IPC分类号: C07D345/00 , C07D239/00 , C07D233/00
CPC分类号: C07D403/04 , A61K31/506 , A61K45/06
摘要: The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.
摘要翻译: 本发明提供式I或II的化合物:其中R1,R1b,R2,R3,R4,R5,R6和R7如本文所定义。 式(I)或(II)的化合物及其药物组合物可用于治疗B-Raf相关疾病。
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公开(公告)号:US20100029605A1
公开(公告)日:2010-02-04
申请号:US12444129
申请日:2007-09-24
申请人: Pamela Albaugh , Gregory S. Chopiuk , Qiang Ding , Shenlin Huang , Zuosheng Liu , Shifeng Pan , Pingda Ren , Xia Wang , Xing Wang , yongping Xie , Chengzhi Zhang , Qiong Zhang , Guobao Zhang , Daniel Poon , Paul Renhowe , Martin Sendzik
发明人: Pamela Albaugh , Gregory S. Chopiuk , Qiang Ding , Shenlin Huang , Zuosheng Liu , Shifeng Pan , Pingda Ren , Xia Wang , Xing Wang , yongping Xie , Chengzhi Zhang , Qiong Zhang , Guobao Zhang , Daniel Poon , Paul Renhowe , Martin Sendzik
IPC分类号: A61K31/506 , C07D413/14 , C07D403/14 , C07D403/04 , A61K31/5377 , A61K31/519
CPC分类号: C07D403/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D417/14
摘要: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, ARG, BCR-Abl, BRK, EphB, Fms, Fyn, KDR, c-Kit, LCK, PDGF-R, b-Raf, c-Raf, SAPK2, Src, Tie2 and TrkB kinases.
摘要翻译: 本发明提供了一类新颖的化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法,特别是涉及Abl,ARG,BCR异常活化的疾病或病症 -Abl,BRK,EphB,Fms,Fyn,KDR,c-Kit,LCK,PDGF-R,b-Raf,c-Raf,SAPK2,Src,Tie2和TrkB激酶。
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公开(公告)号:US08202876B2
公开(公告)日:2012-06-19
申请号:US12444129
申请日:2007-09-24
申请人: Pamela Albaugh , Gregory B. Chopiuk , Qiang Ding , Shenlin Huang , Zuosheng Liu , Shifeng Pan , Pingda Ren , Xia Wang , Xing Wang , Yongping Xie , Chengzhi Zhang , Qiong Zhang , Guobao Zhang , Daniel Poon , Paul Renhowe , Martin Sendzik
发明人: Pamela Albaugh , Gregory B. Chopiuk , Qiang Ding , Shenlin Huang , Zuosheng Liu , Shifeng Pan , Pingda Ren , Xia Wang , Xing Wang , Yongping Xie , Chengzhi Zhang , Qiong Zhang , Guobao Zhang , Daniel Poon , Paul Renhowe , Martin Sendzik
IPC分类号: C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D231/00 , C07D403/02 , A01N43/56 , A61K31/415
CPC分类号: C07D403/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D417/14
摘要: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, ARG, BCR-Abl, BRK, EphB, Fms, Fyn, KDR, c-Kit, LCK, PDGF-R, b-Raf, c-Raf, SAPK2, Src, Tie2 and TrkB kinases.
摘要翻译: 本发明提供了一类新颖的化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法,特别是涉及Abl,ARG,BCR异常活化的疾病或病症 -Abl,BRK,EphB,Fms,Fyn,KDR,c-Kit,LCK,PDGF-R,b-Raf,c-Raf,SAPK2,Src,Tie2和TrkB激酶。
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