-
公开(公告)号:US07572811B2
公开(公告)日:2009-08-11
申请号:US10590618
申请日:2005-02-24
申请人: Shifeng Pan , Thomas Marsilje , Wenshuo Lu , Wenqi Gao , Nathanael Schiander Gray , Yun He , Yahua Liu , Yuan Mi , Yongping Xie
发明人: Shifeng Pan , Thomas Marsilje , Wenshuo Lu , Wenqi Gao , Nathanael Schiander Gray , Yun He , Yahua Liu , Yuan Mi , Yongping Xie
IPC分类号: A61K31/445 , C07D211/30
CPC分类号: C07D401/04 , C07D205/04 , C07D207/08 , C07D207/12 , C07D211/22 , C07D213/74 , C07D237/22 , C07D239/46 , C07D295/108 , C07D295/15 , C07D401/06 , C07D403/04 , C07D403/06 , C07D409/04 , C07D409/12 , C07D413/10 , C07D417/10
摘要: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要翻译: 本发明涉及免疫抑制剂,其生产方法及其用途和含有它们的药物组合物。 本发明提供了一类新颖的化合物,其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症,特别是与EDG受体介导的信号转导相关的疾病。
-
公开(公告)号:US20070203100A1
公开(公告)日:2007-08-30
申请号:US10590618
申请日:2005-02-24
申请人: Shifeng Pan , Thomas Marsilje , Wenshuo Lu , Gao Wenqi , Nathanael Gray , Yun He , Yahua Liu , Yuan Mi , Yongping Xie
发明人: Shifeng Pan , Thomas Marsilje , Wenshuo Lu , Gao Wenqi , Nathanael Gray , Yun He , Yahua Liu , Yuan Mi , Yongping Xie
IPC分类号: A61K31/675 , A61K31/495 , A61K31/454 , A61K31/453 , A61K31/40
CPC分类号: C07D401/04 , C07D205/04 , C07D207/08 , C07D207/12 , C07D211/22 , C07D213/74 , C07D237/22 , C07D239/46 , C07D295/108 , C07D295/15 , C07D401/06 , C07D403/04 , C07D403/06 , C07D409/04 , C07D409/12 , C07D413/10 , C07D417/10
摘要: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要翻译: 本发明涉及免疫抑制剂,其生产方法及其用途和含有它们的药物组合物。 本发明提供了一类新颖的化合物,其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症,特别是与EDG受体介导的信号转导相关的疾病。
-
公开(公告)号:US07718704B2
公开(公告)日:2010-05-18
申请号:US10590606
申请日:2005-02-24
申请人: Shifeng Pan , Wenqi Gao , Nathanael Schiander Gray , Yuan Mi
发明人: Shifeng Pan , Wenqi Gao , Nathanael Schiander Gray , Yuan Mi
IPC分类号: C07C251/50 , C07D311/68 , C07D241/04 , C07D215/40 , C07D205/04 , A61K31/15 , A61K31/197 , A61K31/353 , A61K31/397 , A61K31/4704 , A61K31/495
CPC分类号: C07D311/68 , C07C251/52 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D205/04 , C07D215/40 , C07D295/15 , C07D401/06 , C07D405/06 , C07D491/04 , C07D491/052
摘要: The invention provides a novel class of cyclic oximes of Formula I: wherein A, X, Y, Z, W, R1, R2, R3 and n are as described in the summary of the invention; useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要翻译: 本发明提供式I的新一类环状肟:其中A,X,Y,Z,W,R 1,R 2,R 3和n如本发明概述所述; 可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症,特别是与EDG受体介导的信号转导相关的疾病。
-
公开(公告)号:US20090131400A1
公开(公告)日:2009-05-21
申请号:US12180479
申请日:2008-07-25
申请人: Yuan Mi , Shifeng Pan , Nathanael Schiander Gray , Wenqi Gao , Yi Fan , Tao Jiang
发明人: Yuan Mi , Shifeng Pan , Nathanael Schiander Gray , Wenqi Gao , Yi Fan , Tao Jiang
IPC分类号: A61K31/397 , C07D333/50 , A61K31/381 , C07D409/02 , A61K31/4535 , C07D495/02 , A61K31/4365
CPC分类号: C07D333/58 , C07D261/20 , C07D409/06 , C07D471/04 , C07D473/00 , C07D513/04
摘要: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要翻译: 本发明涉及免疫抑制剂,其生产方法及其用途和含有它们的药物组合物。 本发明提供了一类新颖的化合物,其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症,特别是与EDG受体介导的信号转导相关的疾病。
-
公开(公告)号:US07750021B2
公开(公告)日:2010-07-06
申请号:US12180479
申请日:2008-07-25
申请人: Yuan Mi , Shifeng Pan , Nathanael Schiander Gray , Wenqi Gao , Yi Fan , Tao Jiang
发明人: Yuan Mi , Shifeng Pan , Nathanael Schiander Gray , Wenqi Gao , Yi Fan , Tao Jiang
IPC分类号: A61K31/343 , A61K31/352 , A61K31/396 , A61K31/4035 , A61K31/404 , A61K31/416 , A61K31/423 , A61K31/428 , A61K31/4365 , A61K31/437 , C07D263/56 , C07D277/64 , C07D231/56 , C07D209/04 , C07D513/04 , C07D493/04
CPC分类号: C07D333/58 , C07D261/20 , C07D409/06 , C07D471/04 , C07D473/00 , C07D513/04
摘要: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要翻译: 本发明涉及免疫抑制剂,其生产方法及其用途和含有它们的药物组合物。 本发明提供了一类新颖的化合物,其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症,特别是与EDG受体介导的信号转导相关的疾病。
-
公开(公告)号:US07417065B2
公开(公告)日:2008-08-26
申请号:US10849458
申请日:2004-05-19
申请人: Yuan Mi , Shifeng Pan , Nathanael Schiander Gray , Wenqi Gao , Yi Fan , Tao Jiang
发明人: Yuan Mi , Shifeng Pan , Nathanael Schiander Gray , Wenqi Gao , Yi Fan , Tao Jiang
IPC分类号: A61K31/381 , C07D333/62
CPC分类号: C07D333/58 , C07D261/20 , C07D409/06 , C07D471/04 , C07D473/00 , C07D513/04
摘要: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
-
公开(公告)号:US07939519B2
公开(公告)日:2011-05-10
申请号:US12024992
申请日:2008-02-01
申请人: Shifeng Pan , Wenqi Gao , Nathanael S Gray , Yuan Mi , Yi Fan
发明人: Shifeng Pan , Wenqi Gao , Nathanael S Gray , Yuan Mi , Yi Fan
IPC分类号: A61K31/397 , C07D205/00
CPC分类号: C07D205/04 , C07C251/48 , C07C251/52 , C07C251/54 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D207/16 , C07D211/60 , C07D213/30 , C07D213/53 , C07D213/61 , C07D217/04 , C07D295/06 , C07D307/10 , C07D307/12 , C07D307/52 , C07D333/12 , C07D333/16 , C07D333/22
摘要: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要翻译: 本发明涉及免疫抑制剂,其生产方法及其用途和含有它们的药物组合物。 本发明提供了一类新颖的化合物,其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症,特别是与EDG受体介导的信号转导相关的疾病。
-
公开(公告)号:US07462629B2
公开(公告)日:2008-12-09
申请号:US10849450
申请日:2004-05-19
申请人: Shifeng Pan , Nathanael S. Gray , Yuan Mi , Yi Fan , Wenqi Gao
发明人: Shifeng Pan , Nathanael S. Gray , Yuan Mi , Yi Fan , Wenqi Gao
IPC分类号: A61K31/4725 , A61K31/4035 , A61K31/397 , C07D217/12 , C07D209/44 , C07D205/12
CPC分类号: C07C323/32 , C07C317/32 , C07C2601/14 , C07D205/04
摘要: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要翻译: 本发明涉及免疫抑制剂,其生产方法及其用途和含有它们的药物组合物。 本发明提供了一类新颖的化合物,其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症,特别是与EDG受体介导的信号转导相关的疾病。
-
公开(公告)号:US20050014728A1
公开(公告)日:2005-01-20
申请号:US10849323
申请日:2004-05-19
申请人: Shifeng Pan , Wenqi Gao , Nathanael Gray , Yuan Mi , Yi Fan
发明人: Shifeng Pan , Wenqi Gao , Nathanael Gray , Yuan Mi , Yi Fan
IPC分类号: A41H43/04 , A61K20060101 , A61K31/135 , A61K31/195 , A61K31/41 , A61K31/66 , B29C65/50 , C07D211/28 , C07F9/28 , D06H5/00
CPC分类号: C07D205/04 , C07C251/48 , C07C251/52 , C07C251/54 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D207/16 , C07D211/60 , C07D213/30 , C07D213/53 , C07D213/61 , C07D217/04 , C07D295/06 , C07D307/10 , C07D307/12 , C07D307/52 , C07D333/12 , C07D333/16 , C07D333/22
摘要: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要翻译: 本发明涉及免疫抑制剂,其生产方法及其用途和含有它们的药物组合物。 本发明提供了一类新颖的化合物,其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症,特别是与EDG受体介导的信号转导相关的疾病。
-
公开(公告)号:US20090036423A1
公开(公告)日:2009-02-05
申请号:US12024992
申请日:2008-02-01
申请人: Shifeng Pan , Wenqi Gao , Nathanael S. Gray , Yuan Mi , Yi Fan
发明人: Shifeng Pan , Wenqi Gao , Nathanael S. Gray , Yuan Mi , Yi Fan
IPC分类号: A61K31/192 , C07C207/00 , A61K31/397 , C07D205/04 , C07D213/55 , A61K31/44 , A61K31/445 , C07D211/60 , C07D307/02 , A61K31/34 , A61K31/381 , C07D333/22 , C07D207/04 , A61K31/40 , A61K31/472 , C07D217/00 , A61P29/00 , A61P37/00 , A61P9/00
CPC分类号: C07D205/04 , C07C251/48 , C07C251/52 , C07C251/54 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D207/16 , C07D211/60 , C07D213/30 , C07D213/53 , C07D213/61 , C07D217/04 , C07D295/06 , C07D307/10 , C07D307/12 , C07D307/52 , C07D333/12 , C07D333/16 , C07D333/22
摘要: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要翻译: 本发明涉及免疫抑制剂,其生产方法及其用途和含有它们的药物组合物。 本发明提供了一类新颖的化合物,其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症,特别是与EDG受体介导的信号转导相关的疾病。
-
-
-
-
-
-
-
-
-