公开(公告)号：US20090098061A1

公开(公告)日：2009-04-16

申请号：US11917026

申请日：2006-06-08

申请人： Shigeki Suzuki ,  Yoshikatsu Miwa ,  Nobuo Sasaki ,  Yuiichi Tei

发明人： Shigeki Suzuki ,  Yoshikatsu Miwa ,  Nobuo Sasaki ,  Yuiichi Tei

IPC分类号： A61K9/12 ,  C13K13/00 ,  A61K31/715

CPC分类号： A61K31/7016 ,  A61L31/042

摘要： The objective of the invention is to provide a solution for tissue adhesion prevention and a method for tissue adhesion prevention that are applicable to general surgery and in which covering condition during surgery is stable and convenient. The invention is the solution for tissue adhesion prevention of which the active ingredient is trehalose. Also, it contains at least one or more among antioxidants, chelates, antiseptics, hemostatics, anti-inflammatory agents, and polysaccharides, mucopolysaccharides, salts of polysaccharides and salts of mucopolysaccharides having lubricating properties. This solution for tissue adhesion prevention is provided as any form of perfusion fluid, spray fluid, solution for spray or vaporization administration, foam-like aerosol preparation, injection solution for intravenous fluids, intravenous fluid.

摘要翻译： 本发明的目的是提供一种适用于一般手术的组织粘连防止方法和组织粘连防止方法，其中手术中的覆盖状态是稳定和方便的。 本发明是用于组织粘附预防的方法，其中活性成分是海藻糖。 此外，它还含有至少一种或多种抗氧化剂，螯合物，防腐剂，止血剂，抗炎剂和多糖，粘多糖，多糖的盐和具有润滑性质的粘多糖的盐中的至少一种或多种。 用于组织粘附防止的这种解决方案提供为任何形式的灌注液，喷雾液，用于喷雾或蒸发给药的溶液，泡沫状气溶胶制剂，静脉注射液注射液，静脉注射液。

公开(公告)号：US09155751B2

公开(公告)日：2015-10-13

申请号：US13047551

申请日：2011-03-14

申请人： Shigeki Suzuki ,  Yoshikatsu Miwa ,  Nobuo Sasaki ,  Yuiichi Tei

发明人： Shigeki Suzuki ,  Yoshikatsu Miwa ,  Nobuo Sasaki ,  Yuiichi Tei

IPC分类号： A61K31/7016 ,  A61P41/00 ,  A61K31/7048 ,  A61P39/06 ,  A61L31/04

CPC分类号： A61K31/7016 ,  A61L31/042

摘要： The objective of the invention is to provide a solution for tissue adhesion prevention and a method for tissue adhesion prevention that are applicable to general surgery and in which covering condition during surgery is stable and convenient. The invention is the solution for tissue adhesion prevention of which the active ingredient is trehalose. Also, it contains at least one or more among antioxidants, chelates, antiseptics, hemostatics, anti-inflammatory agents, and polysaccharides, mucopolysaccharides, salts of polysaccharides and salts of mucopolysaccharides having lubricating properties. This solution for tissue adhesion prevention is provided as any form of perfusion fluid, spray fluid, solution for spray or vaporization administration, foam-like aerosol preparation, injection solution for intravenous fluids, intravenous fluid.

摘要翻译： 本发明的目的是提供一种适用于一般手术的组织粘连防止方法和组织粘连防止方法，其中手术中的覆盖状态是稳定和方便的。 本发明是用于组织粘附预防的方法，其中活性成分是海藻糖。 此外，它还含有至少一种或多种抗氧化剂，螯合物，防腐剂，止血剂，抗炎剂和多糖，粘多糖，多糖的盐和具有润滑性质的粘多糖的盐中的至少一种或多种。 用于组织粘附防止的这种解决方案提供为任何形式的灌注液，喷雾液，用于喷雾或蒸发给药的溶液，泡沫状气溶胶制剂，静脉注射液注射液，静脉注射液。

公开(公告)号：US08906111B2

公开(公告)日：2014-12-09

申请号：US13002148

申请日：2009-07-01

申请人： Yuichi Tei ,  Nobuo Sasaki ,  Shigeki Suzuki

发明人： Yuichi Tei ,  Nobuo Sasaki ,  Shigeki Suzuki

IPC分类号： A61L27/00 ,  A61L27/50 ,  A61L27/12

CPC分类号： A61L27/50 ,  A61L27/12 ,  A61L2430/02

摘要： Disclosed is an artificial bone material having controlled calcium ion elution, which does not induce cytotoxicity or any inflammatory response. It is found that the elution of a calcium ion from an artificial bone material for transplantation which contains a calcium-containing substance can be prevented effectively by subjecting the carrier to a surface treatment or adding a surface-treating agent to the carrier. It is also found that the induction of cytotoxicity can be prevented and the induction of an inflammatory response can also be prevented by using the above-mentioned carrier having controlled calcium ion elution.

摘要翻译： 公开了具有受控钙离子洗脱的人造骨材料，其不诱导细胞毒性或任何炎性反应。 发现通过对载体进行表面处理或向载体添加表面处理剂，可以有效地防止钙离子从含有含钙物质的移植用人造骨材料中的洗脱。 还可以发现，通过使用具有受控钙离子洗脱的上述载体，也可以防止诱导细胞毒性并诱导炎症反应。

公开(公告)号：US08283337B2

公开(公告)日：2012-10-09

申请号：US12528116

申请日：2008-02-22

申请人： Nobuo Sasaki ,  Yuichi Tei ,  Ryosuke Echigo ,  Shigeki Suzuki ,  Touru Hakukawa

发明人： Nobuo Sasaki ,  Yuichi Tei ,  Ryosuke Echigo ,  Shigeki Suzuki ,  Touru Hakukawa

IPC分类号： A01N43/04 ,  A61K31/715 ,  C13K5/00 ,  C13K7/00

CPC分类号： A61K31/7016

摘要： An object of the present invention is to provide an agent for treating or preventing vasospasm. An object of the present invention is to provide an agent for treating or preventing cerebral vasospasm as well as arterial vasospasm. Further, an object of the present invention is to provide an agent for treating or preventing cerebral ischemia and cerebral infarction.The above problems are solved by an agent for treating and preventing vasospasm, cerebral ischemia, or cerebral infarction, comprising trehalose as the active ingredient. It is possible, by using such a trehalose-comprising agent, to suppress phenomena such as contraction of blood vessel and thickening of tunica intima and tunica media and to prevent or treat vasospasm and vasospasm-dependent diseases.

摘要翻译： 本发明的目的在于提供治疗或预防血管痉挛的药剂。 本发明的目的是提供治疗或预防脑血管痉挛以及动脉血管痉挛的药剂。 此外，本发明的目的是提供治疗或预防脑缺血和脑梗死的药剂。 上述问题由包含海藻糖作为活性成分的治疗和预防血管痉挛，脑缺血或脑梗死的药物解决。 通过使用这样的含海藻糖的试剂可以抑制血管收缩等现象，并且可以抑制内膜和中膜介质的增厚以及预防或治疗血管痉挛和血管痉挛依赖性疾病。

公开(公告)号：US20120122949A1

公开(公告)日：2012-05-17

申请号：US13139629

申请日：2009-06-19

申请人： Yuichi Tei ,  Takamasa Sakai ,  Nobuo Sasaki ,  Mitsuhiro Shibayama ,  Shigeki Suzuki

发明人： Yuichi Tei ,  Takamasa Sakai ,  Nobuo Sasaki ,  Mitsuhiro Shibayama ,  Shigeki Suzuki

IPC分类号： A61K31/132 ,  A61P19/00 ,  A61K31/4025

CPC分类号： C08G65/33306 ,  C08G65/3324 ,  C08G65/33337 ,  C08G2650/50 ,  C08L71/02 ,  C08L2203/02 ,  C08L2666/22

摘要： [Problem]The present invention is intended to provide high-strength hydrogels and method for fabricating the same. The present invention is intended to provide the method for fabricating the hydrogels with different decomposition rates.[Solution to Problem] The present invention is based on a knowledge that high-strength hydrogels can be fabricated by controlling pH of solution, ionic strength in the solution, and buffer concentration in the solution. In addition, the present invention is based on a knowledge that the high-strength hydrogels which have homogeneous macromolecular network structure can be fabricated by polymerizing four-branching compounds after having dispersed the four-branching compounds homogeneously.

摘要翻译： 本发明旨在提供高强度水凝胶及其制造方法。 本发明旨在提供具有不同分解速率的水凝胶的制造方法。 [问题的解决方案]本发明基于如下知识：可以通过控制溶液的pH，溶液中的离子强度和溶液中的缓冲液浓度来制造高强度水凝胶。 此外，本发明基于以下知识：具有均匀的大分子网络结构的高强度水凝胶可以通过在分散四支化合物均匀后聚合四支化合物来制备。

公开(公告)号：US20120097169A1

公开(公告)日：2012-04-26

申请号：US13265880

申请日：2010-04-26

申请人： Yuichi Tei ,  Nobuo Sasaki ,  Shigeki Suzuki

发明人： Yuichi Tei ,  Nobuo Sasaki ,  Shigeki Suzuki

IPC分类号： A61M16/04 ,  B05D3/00 ,  B05D1/18 ,  C09D143/02 ,  B05D7/00

CPC分类号： A61L17/145 ,  A61L29/085 ,  C08L101/02

摘要： Disclosed is a respiration-assisting tube whereby tissue damages in vivo can be prevented and, as a result, inflammatory reactions and infections can be avoided. The respiration-assisting tube is developed based on the finding that adhesion of cells to a respiration-assisting tube can be inhibited by coating the respiration-assisting tube with a polymer containing 2-methacryloyloxyethyl phosphorylcholine (MPC). Also, the respiration-assisting tube is developed based on the finding that, by coating a respiration-assisting tube with a polymer containing MPC, mucosa peeling and tissue damages, which occur after using the respiration-assisting tube, can be prevented and, as a result, inflammatory reactions can be avoided.

摘要翻译： 公开了一种呼吸辅助管，其中可以防止体内的组织损伤，结果可以避免炎性反应和感染。 基于通过用含有2-甲基丙烯酰氧基乙基磷酰胆碱（MPC）的聚合物涂覆呼吸辅助管可以抑制细胞对呼吸辅助管的粘附的发现来开发呼吸辅助管。 此外，基于以下发现，开发了呼吸辅助管：通过使用含有MPC的聚合物涂覆呼吸辅助管，在使用呼吸辅助管之后发生粘膜剥离和组织损伤的发现，并且作为 结果可以避免炎症反应。

公开(公告)号：US20110166672A1

公开(公告)日：2011-07-07

申请号：US13002141

申请日：2009-06-29

申请人： Yuichi Tei ,  Nobuo Sasaki ,  Shigeki Suzuki

发明人： Yuichi Tei ,  Nobuo Sasaki ,  Shigeki Suzuki

IPC分类号： A61F2/28

CPC分类号： A61L27/365 ,  A61F2002/30303 ,  A61F2230/0063 ,  A61L27/025 ,  A61L27/12 ,  A61L27/3616 ,  A61L2430/02

摘要： An object of the invention is to provide a bone filling material capable of promoting the bone regeneration effect of a growth factor such as platelet rich plasma (PRP).Inventors of the invention anticipated that the bone filling material adsorbs a growth factor like PRP, and the combined use of the bone filling material with PRP, the bone regeneration effect of PRP might be impaired. Further, the invention is basically related to the inhibition of this adsorbing effect of the bone filling material by using a capping agent. Since the adsorbing effect of the bone filling material is thus inhibited, PRP can exert the bone regeneration effect thereof in the case of using the bone filling material together with PRP.

摘要翻译： 本发明的目的是提供能够促进生长因子如富血小板血浆（PRP）的骨再生作用的骨填充材料。 本发明的发明人预期，骨填充材料吸附生长因子如PRP，并且骨填充材料与PRP的组合使用可能会损害PRP的骨再生作用。 此外，本发明基本上与通过使用封端剂抑制骨填充材料的吸附效果有关。 由于能够抑制骨填充材料的吸附效果，所以在与PRP一起使用骨填充材料的情况下，PRP能够发挥骨再生效果。

公开(公告)号：US20100035837A1

公开(公告)日：2010-02-11

申请号：US12528116

申请日：2008-02-22

申请人： Nobuo Sasaki ,  Yuichi Tei ,  Ryosuke Echigo ,  Shigeki Suzuki ,  Touru Hakukawa

发明人： Nobuo Sasaki ,  Yuichi Tei ,  Ryosuke Echigo ,  Shigeki Suzuki ,  Touru Hakukawa

IPC分类号： A61K31/7016 ,  C13K13/00

CPC分类号： A61K31/7016

摘要： An object of the present invention is to provide an agent for treating or preventing vasospasm. An object of the present invention is to provide an agent for treating or preventing cerebral vasospasm as well as arterial vasospasm. Further, an object of the present invention is to provide an agent for treating or preventing cerebral ischemia and cerebral infarction.The above problems are solved by an agent for treating and preventing vasospasm, cerebral ischemia, or cerebral infarction, comprising trehalose as the active ingredient. It is possible, by using such a trehalose-comprising agent, to suppress phenomena such as contraction of blood vessel and thickening of tunica intima and tunica media and to prevent or treat vasospasm and vasospasm-dependent diseases.

摘要翻译： 本发明的目的在于提供治疗或预防血管痉挛的药剂。 本发明的目的是提供治疗或预防脑血管痉挛以及动脉血管痉挛的药剂。 此外，本发明的目的是提供治疗或预防脑缺血和脑梗死的药剂。 上述问题由包含海藻糖作为活性成分的治疗和预防血管痉挛，脑缺血或脑梗死的药物解决。 通过使用这样的含海藻糖的试剂可以抑制血管收缩等现象，并且可以抑制内膜和中膜介质的增厚以及预防或治疗血管痉挛和血管痉挛依赖性疾病。

公开(公告)号：US20100003301A1

公开(公告)日：2010-01-07

申请号：US12514077

申请日：2007-11-08

申请人： Nobuo Sasaki ,  Yuichi Tei ,  Kazuyo Igawa ,  Shigeki Suzuki ,  Koutaro Shimizu

发明人： Nobuo Sasaki ,  Yuichi Tei ,  Kazuyo Igawa ,  Shigeki Suzuki ,  Koutaro Shimizu

IPC分类号： A61F2/00

CPC分类号： A61K9/0024 ,  A61F2002/30303 ,  A61F2230/0063 ,  A61L27/12 ,  A61L27/54 ,  A61L2300/404 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/802 ,  A61L2430/02

摘要： A bone filling material having controlled release of a pharmaceutical agent such as a growth factor, and a drug release controlling carrier having controlled release of a pharmaceutical agent is provided by inactivating a functional group which can strongly bind to the pharmaceutical agent of the bone filling material with a blocking agent. The bone filling material and the drug release controlling carrier of the present invention comprises: a calcium-based material such as hydroxyapatite, carbonate apatite, fluorapatite, chlorapatite, β-TCP, and α-TCP; a blocking agent of the calcium-based material such as serine and dextran; and a pharmaceutical agent.

摘要翻译： 通过使能够与骨填充材料的药剂牢固结合的官能团失活来提供具有药剂如受体释放的骨填充材料，例如生长因子和具有药物释放控制的药物释放控制载体 与阻断剂。 本发明的骨填充材料和药物释放控制载体包括：钙基材料如羟基磷灰石，碳酸磷灰石，氟磷灰石，氯磷灰石，β-TCP和α-TCP; 钙基材料如丝氨酸和葡聚糖的封闭剂; 和药剂。

公开(公告)号：US20120123542A1

公开(公告)日：2012-05-17

申请号：US13386032

申请日：2010-07-22

申请人： Shigeki Suzuki ,  Yuichi Tei ,  Nobuo Sasaki ,  Jianmei He

发明人： Shigeki Suzuki ,  Yuichi Tei ,  Nobuo Sasaki ,  Jianmei He

IPC分类号： A61F2/28

CPC分类号： A61F2/28 ,  A61F2002/30143 ,  A61F2002/30156 ,  A61F2002/30158 ,  A61F2002/3038 ,  A61F2002/30448 ,  A61F2002/30604 ,  A61F2002/30784 ,  A61F2002/3082

摘要： Provided are an artificial bone constructing unit which is capable of being built into a free shape according to build-up design, and effectively guiding bone replacement, and an artificial bone system. Specifically disclosed are an artificial bone constructing unit and an artificial bone constructing system, wherein in principal, the artificial bone constructing unit which constructs an artificial bone is so made into a block shape that when blocks are assembled, continuous holes through a plurality of blocks are formed.

摘要翻译： 提供一种人造骨构造单元，其能够根据积聚设计被自由形状，并且有效地引导骨置换，以及人造骨系统。 具体公开了一种人造骨构造单元和人造骨构造系统，其中，构成人造骨的人造骨构造单元的原理是将其制成块状，当块组装时，通过多个块的连续孔为 形成。