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公开(公告)号：US08039236B2
公开(公告)日：2011-10-18
申请号：US12406330
申请日：2009-03-18
申请人： Shin-ichi Hashimoto , Kazuhiko Tabata , Aya Kubota , Hajime Ikeda
发明人： Shin-ichi Hashimoto , Kazuhiko Tabata , Aya Kubota , Hajime Ikeda
摘要： The present invention provides a protein which catalyzes the synthesis of a dipeptide different from L-Ala-L-Ala, a process for producing the protein which catalyzes the synthesis of a dipeptide, a process for producing a dipeptide using the protein which catalyzes the synthesis of a dipeptide, and a process for producing the dipeptide using a culture of a microorganism producing the protein which catalyzes the synthesis of a dipeptide or the like as an enzyme source.
摘要翻译： 本发明提供了催化不同于L-Ala-L-Ala的二肽的合成的蛋白质，用于生产催化二肽合成的蛋白质的方法，使用催化合成的蛋白质生产二肽的方法 的二肽的方法，以及使用产生作为酶源的二肽等的合成的蛋白质的微生物的培养物来生成二肽的方法。
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公开(公告)号：US20090191589A1
公开(公告)日：2009-07-30
申请号：US12406330
申请日：2009-03-18
申请人： Shin-ichi Hashimoto , Kazuhiko Tabata , Aya Kubota , Hajime Ikeda
发明人： Shin-ichi Hashimoto , Kazuhiko Tabata , Aya Kubota , Hajime Ikeda
IPC分类号： C12P21/02
摘要： The present invention provides a protein which catalyzes the synthesis of a dipeptide different from L-Ala-L-Ala, a process for producing the protein which catalyzes the synthesis of a dipeptide, a process for producing a dipeptide using the protein which catalyzes the synthesis of a dipeptide, and a process for producing the dipeptide using a culture of a microorganism producing the protein which catalyzes the synthesis of a dipeptide or the like as an enzyme source.
摘要翻译： 本发明提供了催化不同于L-Ala-L-Ala的二肽的合成的蛋白质，用于生产催化二肽合成的蛋白质的方法，使用催化合成的蛋白质生产二肽的方法 的二肽的方法，以及使用产生作为酶源的二肽等的合成的蛋白质的微生物的培养物来生成二肽的方法。
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公开(公告)号：US07514242B2
公开(公告)日：2009-04-07
申请号：US10746264
申请日：2003-12-29
摘要： The present invention provides a protein which catalyzes the synthesis of a dipeptide different from L-Ala-L-Ala, a process for producing the protein which catalyzes the synthesis of a dipeptide, a process for producing a dipeptide using the protein which catalyzes the synthesis of a dipeptide, and a process for producing the dipeptide using a culture of a microorganism producing the protein which catalyzes the synthesis of a dipeptide or the like as an enzyme source.
摘要翻译： 本发明提供了催化不同于L-Ala-L-Ala的二肽的合成的蛋白质，用于生产催化二肽合成的蛋白质的方法，使用催化合成的蛋白质生产二肽的方法 的二肽的方法，以及使用产生作为酶源的二肽等的合成的蛋白质的微生物的培养物来生成二肽的方法。
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公开(公告)号：US20080213827A1
公开(公告)日：2008-09-04
申请号：US11630397
申请日：2005-06-24
CPC分类号： C12P21/02
摘要： The present invention provides a process for producing a dipeptide or a dipeptide derivative by using a protein having the activity to form the dipeptide or dipeptide derivative from one or more kinds of amino acids or amino acid derivatives, or a culture of cells having the ability to produce the protein or a treated matter of the culture as a enzyme source, which comprise;allowing the enzyme source, one or more kinds of amino acids or amino acid derivatives and ATP to be present in an aqueous medium; allowing the dipeptide or dipeptide derivative to form and accumulate in the medium; and recovering the dipeptide or dipeptide derivative from the medium.
摘要翻译： 本发明提供了通过使用具有从一种或多种氨基酸或氨基酸衍生物形成二肽或二肽衍生物的活性的蛋白质或具有以下能力的细胞培养物来生产二肽或二肽衍生物的方法： 产生蛋白质或培养物的处理物质作为酶源，其包含： 允许酶源，一种或多种氨基酸或氨基酸衍生物和ATP存在于水性介质中; 允许二肽或二肽衍生物在培养基中形成和积累; 并从培养基中回收二肽或二肽衍生物。
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公开(公告)号：US20120258490A1
公开(公告)日：2012-10-11
申请号：US13430937
申请日：2012-03-27
CPC分类号： C12N9/93 , C07K5/06 , C07K14/34 , C12N9/1229 , C12P21/02
摘要： The present invention provides a process for producing a dipeptide or a dipeptide derivative using a phosphate donor, a substance selected from the group consisting of adenosine-5′-monophosphate, adenosine-5′-diphosphate and adenosine-5′-triphosphate, one or more kinds of amino acids or amino acid derivatives, and as enzyme sources, a protein having polyphosphate kinase activity, or a culture of cells having the ability to produce the protein or a treated matter of the culture, and a protein having the activity to ATP-dependently form the dipeptide or dipeptide derivative from one or more kinds of amino acids or amino acid derivatives, or a culture of cells having the ability to produce the protein or a treated matter of the culture.
摘要翻译： 本发明提供了使用磷酸盐供体，选自腺苷-5'-磷酸，腺苷-5'-二磷酸和腺苷-5'-三磷酸的物质制备二肽或二肽衍生物的方法，其中一种或 更多种类的氨基酸或氨基酸衍生物，作为酶源，具有多磷酸激酶活性的蛋白质，或具有产生蛋白质的能力的细胞培养物或培养物的处理物质，以及具有ATP活性的蛋白质 依赖性地形成来自一种或多种氨基酸或氨基酸衍生物的二肽或二肽衍生物，或具有产生蛋白质的能力的细胞培养物或培养物的处理物质。
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公开(公告)号：US08257943B2
公开(公告)日：2012-09-04
申请号：US11165226
申请日：2005-06-24
CPC分类号： C12N9/93 , C07K5/06 , C07K14/34 , C12N9/1229 , C12P21/02
摘要： The present invention provides a process for producing a dipeptide or a dipeptide derivative using a phosphate donor, a substance selected from the group consisting of adenosine-5′-monophosphate, adenosine-5′-diphosphate and adenosine-5′-triphosphate, one or more kinds of amino acids or amino acid derivatives, and as enzyme sources, a protein having polyphosphate kinase activity, or a culture of cells having the ability to produce the protein or a treated matter of the culture, and a protein having the activity to ATP-dependently form the dipeptide or dipeptide derivative from one or more kinds of amino acids or amino acid derivatives, or a culture of cells having the ability to produce the protein or a treated matter of the culture.
摘要翻译： 本发明提供了使用磷酸盐供体，选自腺苷-5'-磷酸，腺苷-5'-二磷酸和腺苷-5'-三磷酸的物质制备二肽或二肽衍生物的方法，其中一种或 更多种类的氨基酸或氨基酸衍生物，作为酶源，具有多磷酸激酶活性的蛋白质，或具有产生蛋白质的能力的细胞培养物或培养物的处理物质，以及具有ATP活性的蛋白质 依赖性地形成来自一种或多种氨基酸或氨基酸衍生物的二肽或二肽衍生物，或具有产生蛋白质的能力的细胞培养物或培养物的处理物质。
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7.发明授权Amino acid racemase having low substrate specificity and process for producing racemic amino acid 有权具有低底物特异性的氨基酸消旋酶和用于生产外消旋氨基酸的方法公开(公告)号：US07247466B2
公开(公告)日：2007-07-24
申请号：US10506152
申请日：2003-02-28
摘要： The present invention provides a protein having low-substrate-specific amino acid racemase activity; DNA encoding the protein; a recombinant DNA comprising the DNA; a transformant carrying the recombinant DNA; a process for producing the protein by using the transformant; and a process for producing a racemic amino acid which comprises allowing a culture of the transformant or a treated matter thereof as an enzyme source and an amino acid to be present in an aqueous medium to racemize the amino acid in the aqueous medium, and recovering the racemic amino acid from the aqueous medium.
摘要翻译： 本发明提供了具有低底物特异性氨基酸消旋酶活性的蛋白质; 编码蛋白质的DNA; 包含DNA的重组DNA; 携带重组DNA的转化体; 通过使用转化体生产蛋白质的方法; 以及制备外消旋氨基酸的方法，其包括使转化体或其处理物质的培养物作为酶源，并且氨基酸存在于水性介质中以使水性介质中的氨基酸外消旋化，并回收 来自水介质的外消旋氨基酸。
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公开(公告)号：US20050287627A1
公开(公告)日：2005-12-29
申请号：US11165226
申请日：2005-06-24
CPC分类号： C12N9/93 , C07K5/06 , C07K14/34 , C12N9/1229 , C12P21/02
摘要： The present invention provides a process for producing a dipeptide or a dipeptide derivative using a phosphate donor, a substance selected from the group consisting of adenosine-5′-monophosphate, adenosine-5′-diphosphate and adenosine-5′-triphosphate, one or more kinds of amino acids or amino acid derivatives, and as enzyme sources, a protein having polyphosphate kinase activity, or a culture of cells having the ability to produce the protein or a treated matter of the culture, and a protein having the activity to ATP-dependently form the dipeptide or dipeptide derivative from one or more kinds of amino acids or amino acid derivatives, or a culture of cells having the ability to produce the protein or a treated matter of the culture.
摘要翻译： 本发明提供了使用磷酸盐供体，选自腺苷-5'-磷酸，腺苷-5'-二磷酸和腺苷-5'-三磷酸的物质制备二肽或二肽衍生物的方法，其中一种或 更多种类的氨基酸或氨基酸衍生物，作为酶源，具有多磷酸激酶活性的蛋白质，或具有产生蛋白质的能力的细胞培养物或培养物的处理物质，以及具有ATP活性的蛋白质 依赖性地形成来自一种或多种氨基酸或氨基酸衍生物的二肽或二肽衍生物，或具有产生蛋白质的能力的细胞培养物或培养物的处理物质。
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9.发明申请Low-substrate-specific amino acid racemase and process for producing racemic amino acid 失效低底物特异性氨基酸消旋酶及其制备外消旋氨基酸的方法公开(公告)号：US20090226999A1
公开(公告)日：2009-09-10
申请号：US11808186
申请日：2007-06-07
摘要： The present invention provides a protein having low-substrate-specific amino acid racemase activity; DNA encoding the protein; a recombinant DNA comprising the DNA; a transformant carrying the recombinant DNA; a process for producing the protein by using the transformant; and a process for producing a racemic amino acid which comprises allowing a culture of the transformant or a treated matter thereof as an enzyme source and an amino acid to be present in an aqueous medium to racemize the amino acid in the aqueous medium, and recovering the racemic amino acid from the aqueous medium.
摘要翻译： 本发明提供了具有低底物特异性氨基酸消旋酶活性的蛋白质; 编码蛋白质的DNA; 包含DNA的重组DNA; 携带重组DNA的转化体; 通过使用转化体生产蛋白质的方法; 以及制备外消旋氨基酸的方法，其包括使转化体或其处理物质的培养物作为酶源，并且氨基酸存在于水性介质中以使水性介质中的氨基酸外消旋化，并回收 来自水介质的外消旋氨基酸。
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公开(公告)号：US07186532B2
公开(公告)日：2007-03-06
申请号：US10415107
申请日：2001-10-29
CPC分类号： C12R1/19 , C12P13/06 , C12P41/001
摘要： The present invention relates to: a process for producing D-serine wherein a microbial cell which is modified to have a higher L-serine deaminase activity than Escherichia coli DH5α strain, a culture of said cell, or a processed product thereof is brought into contact with DL-serine in a DL-serine-containing medium to decompose L-serine, and the remaining D-serine is recovered from the medium; and a microorganism used for this production process. D-serine is a useful compound as a synthetic intermediate for useful medicaments such as D-cycloserine.
摘要翻译： 本发明涉及：生产D-丝氨酸的方法，其中将经修饰以具有比大肠杆菌DH5α菌株更高的L-丝氨酸脱氨酶活性，所述细胞培养物或其加工产物的微生物细胞接触 在DL-丝氨酸培养基中用DL-丝氨酸分解L-丝氨酸，从培养基中回收剩余的D-丝氨酸; 和用于该生产过程的微生物。 D-丝氨酸是有用的药物如D-环丝氨酸作为合成中间体的有用化合物。
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