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11 条记录 (耗时 0.036 秒)

    Process and device to reduce interstitial fluid pressure in tissue
    5.
    发明授权
    Process and device to reduce interstitial fluid pressure in tissue 失效
    减少组织中间质液压力的过程和装置

    公开(公告)号：US5484399A

    公开(公告)日：1996-01-16

    申请号：US181356

    申请日：1994-01-13

    申请人： Gene R. DiResta ,  Jongbin Lee ,  Ehud Arbit

    发明人： Gene R. DiResta ,  Jongbin Lee ,  Ehud Arbit

    IPC分类号： A61M1/00 ,  A61M25/00 ,  A61N1/30

    CPC分类号： A61M1/008 ,  A61M1/0031 ,  A61M2025/0002 ,  A61M2205/3344 ,  A61M2205/3351

    摘要： A method and apparatus are provided for reducing interstitial fluid pressure in tissues, particularly in tumors, by applying suction to the interior of the tissue. The method comprises inserting into the tissue one or more needle-like, elongated tubes, each having at least one hole at or near the end that is inserted into the tissue and each having means to apply suction to the protruding end. The reduced pressure produced inside the tissue by this method is useful to: facilitate penetration by drugs and therapeutic macromolecules into the tissue; enhance radiation treatment of tumors by increasing the oxygen supply in the tumor; and remove fluid to reduce edema in tissues, e.g. brain edema. Means may be provided to measure the pressure within the tissue and to use this measurement to control the suction applied to the tissue through the tubes.

    摘要翻译： 提供了一种方法和装置，用于通过向组织的内部施加抽吸来减少组织，特别是肿瘤中的间质液压。 该方法包括向组织中插入一个或多个针状细长的管，每个细长管具有插入到组织中的端部处或附近的至少一个孔，并且每个具有向突出端施加吸力的装置。 通过该方法在组织内产生的减压可用于：促进药物和治疗性大分子渗入组织中; 通过增加肿瘤中的氧供应来增强肿瘤的放射治疗; 并去除流体以减少组织中的水肿，例如， 脑水肿 可以提供装置来测量组织内的压力并且使用该测量来控制通过管施加到组织的吸力。

    Compositions For Buccal Delivery of Human Growth Hormone
    6.
    发明申请
    Compositions For Buccal Delivery of Human Growth Hormone 失效
    用于人类生长激素的颊传递的组合物

    公开(公告)号：US20080207513A1

    公开(公告)日：2008-08-28

    申请号：US11993941

    申请日：2006-07-05

    申请人： Puchun Liu ,  Steven Dinh ,  Jongbin Lee

    发明人： Puchun Liu ,  Steven Dinh ,  Jongbin Lee

    IPC分类号： A61K38/00 ,  A61P43/00

    CPC分类号： A61K38/27 ,  A61K9/006

    摘要： The present invention provides pharmaceutical compositions for buccal delivery of human growth hormone (hGH) comprising a delivery agent and hGH. The compositions of the present invention provide improved delivery of hGH compared to comparable oral compositions, resulting in increased serum concentrations of hGH. The present invention further provides for methods of stimulating tissue growth in an animal by buccally co-administering hGH and a delivery agent.

    摘要翻译： 本发明提供用于口服输送包含递送剂和hGH的人生长激素（hGH）的药物组合物。 与可比较的口服组合物相比，本发明的组合物提供了hGH的改善的递送，导致hGH的血清浓度增加。 本发明进一步提供通过颊内共施用hGH和递送剂刺激动物中的组织生长的方法。

    Compositions and methods for buccal delivery of human growth hormone
    10.
    发明授权
    Compositions and methods for buccal delivery of human growth hormone 失效
    用于口服输送人生长激素的组合物和方法

    公开(公告)号：US08030271B2

    公开(公告)日：2011-10-04

    申请号：US11993941

    申请日：2006-07-05

    申请人： Puchun Liu ,  Steven Dinh ,  Jongbin Lee

    发明人： Puchun Liu ,  Steven Dinh ,  Jongbin Lee

    IPC分类号： A61K38/27 ,  A61P3/04

    CPC分类号： A61K38/27 ,  A61K9/006

    摘要： The present invention provides pharmaceutical compositions for buccal delivery of human growth hormone (hGH) comprising a delivery agent and hGH. The compositions of the present invention provide improved delivery of hGH compared to comparable oral compositions, resulting in increased serum concentrations of hGH. The present invention further provides for methods of stimulating tissue growth in an animal by buccally co-administering hGH and a delivery agent.

    摘要翻译： 本发明提供用于口服输送包含递送剂和hGH的人生长激素（hGH）的药物组合物。 与可比较的口服组合物相比，本发明的组合物提供了hGH的改善的递送，导致hGH的血清浓度增加。 本发明进一步提供通过颊内共施用hGH和递送剂刺激动物中的组织生长的方法。