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    Process for producing optically active 2-hydroxy-4-arylbutyric acid or its ester
    6.
    发明授权
    Process for producing optically active 2-hydroxy-4-arylbutyric acid or its ester 失效
    光学活性2-羟基-4-芳基丁酸或其酯的制备方法

    公开(公告)号：US06258975B1

    公开(公告)日：2001-07-10

    申请号：US09477740

    申请日：2000-01-05

    申请人： Masahiko Kurauchi ,  Yoshimasa Hagiwara ,  Hiroyuki Matsueda ,  Takashi Nakano ,  Kunisuke Izawa

    发明人： Masahiko Kurauchi ,  Yoshimasa Hagiwara ,  Hiroyuki Matsueda ,  Takashi Nakano ,  Kunisuke Izawa

    IPC分类号： C07C6976

    CPC分类号： C07C69/732 ,  C07C51/377 ,  C07C67/317 ,  C07C67/343 ,  C07C59/48 ,  C07C69/738

    摘要： Provided is an industrially useful process for producing an optically active 2-hydroxy-4-arylbutyric acid or its ester. An optically active acyloxysuccinic anhydride is reacted with an aromatic compound in the presence of a Lewis acid to produce an optically active 2-acyloxy-4-oxo-4-arylbutyric acid. The 2-acyloxy-4-oxo-4-arylbutyric acid is converted to an optically active 2-acyloxy-4-arylbutyric acid through catalytic reduction. The 2-acyloxy-4-arylbutyric acid is hydrolyzed in the presence of an acid or an alkali to produce an optically active 2-hydroxy-4-arylbutyric acid. The 2-hydroxy-4-arylbutyric acid is reacted with an alcohol in the presence of an acid to produce an optically active 2-hydroxy-4-arylbutyric acid ester.

    摘要翻译： 提供了用于制备光学活性2-羟基-4-芳基丁酸或其酯的工业上有用的方法。 在路易斯酸存在下，使光学活性的酰氧基琥珀酸酐与芳族化合物反应，得到光学活性的2-酰氧基-4-氧代-4-芳基丁酸。 通过催化还原将2-酰氧基-4-氧代-4-芳基丁酸转化成光学活性的2-酰氧基-4-芳基丁酸。 2-酰氧基-4-芳基丁酸在酸或碱的存在下水解，得到光学活性的2-羟基-4-芳基丁酸。 2-羟基-4-芳基丁酸与醇在酸的存在下与醇反应，得到光学活性的2-羟基-4-芳基丁酸酯。