摘要:
The present invention provides an agent containing L-tyrosine that prevents methemoglobin formation, and a vesicle comprising the above agent for preventing methemoglobin formation. More specifically, the present invention provides an oxygen infusion preparation suitable for long-term storage, which prevents an increase in methemoglobin content as a result of oxidation of hemoglobin or the like encapsulated in an vesicle having a lipid bilayer membrane structure.
摘要:
An oligosaccharide lipid is provided which has 2 to 20 saccharide units, and has a hydrophobic group linked by an ether linkage to an anomer carbon on a reducing end group. A stabilizer for a phospholipid vesicle is also provided which comprises an oligosaccharide derivative having 2 to 20 saccharide units, and having a hydrophobic group linked by an amide linkage or an ether linkage to an anomer carbon on a reducing end group constituted of an aldose.
摘要:
A pharmaceutical composition containing an artificial oxygen carrier, which has high oxygen carrying efficiency; and has a required colloid osmotic pressure, an appropriate crystalloid osmotic pressure, pH, and electrolyte balance. The composition is prepared by appropriately adding at least one substance selected from the group consisting of a compound capable of providing a colloid osmotic pressure, an electrolyte, a saccharide, an amino acid, an antioxidant, a pH adjuster, and an isotonizing agent to a preparation including a liposome-encapsulated hemoglobin in which a hemoglobin is encapsulated in a liposome or to a preparation including a conjugate of a porphyrin-iron complex and albumin.
摘要:
A method and an apparatus for regenerating an oxygen-binding ability by reducing the methemoglobin contained in hemoglobin-vesicle by light irradiation. This method includes adding electron donors such as amino acids, saccharides, alcohols, and/or flavin derivatives in appropriate amounts to the inner aqueous phase of the hemoglobin-vesicle, applying light to the vesicle when the content of methemoglobin increases as a result of oxidation of hemoglobin, thereby reducing the metohemoglobin. In this manner, the oxygen-binding ability is recovered, thereby maintaining the function of the hemoglobin-vesicle.
摘要:
The present invention provides a method for preserving an oxygen infusion containing an aqueous suspension of molecular assemblies which contain hemoglobin or a heme compound, by: a) modifying the molecular assemblies with polyoxyethylene; and b) converting the hemoglobin or the heme compound into a deoxy-form by removing oxygen from the suspension.
摘要:
A fuel pump has substantially coaxial outer and inner pump chambers. An impeller has partition walls correspondingly to the inner pump chamber to define inner vane grooves. A rear surface is located at a rear side in a rotative direction of each inner vane groove. At least a radially inner side of the rear surface inclines rearward in the rotative direction from the radially inner side to a radially outer side. A first line connects a radially inner end of the rear surface with a radially outer end of the rear surface. A second line radially extends from the radially inner end of the rear surface. The first line and the second line therebetween define a backward tilt angle α2, which satisfies a relationship of 30°≦α2≦80°.
摘要:
A fuel pump has substantially coaxial outer and inner pump chambers. An impeller has partition walls correspondingly to the inner pump chamber to define inner vane grooves. A rear surface is located at a rear side in a rotative direction of each inner vane groove. At least a radially inner side of the rear surface inclines rearward in the rotative direction from the radially inner side to a radially outer side. A first line connects a radially inner end of the rear surface with a radially outer end of the rear surface. A second line radially extends from the radially inner end of the rear surface. The first line and the second line therebetween define a backward tilt angle α2, which satisfies a relationship of 30°≦α2≦80°.
摘要:
A fluid pump includes a motor portion that has a stationary part and a rotator. The inner circumferential periphery of the stationary part and the outer circumferential periphery of the rotator define a fuel passage therebetween. The rotator is rotatable around the inner circumferential periphery of the stationary part. The motor portion drives a pump portion for pumping fuel through the fuel passage. The rotator includes a permanent magnet that is formed by injection molding a composite material containing a magnetic material and resin. The permanent magnet has one end with respect to the axial direction of the permanent magnet. The one end defines an axial end surface. The axial end surface has an injection port mark.
摘要:
Provided is a method for producing vesicles which comprise a lipid as a main component and which encapsulate a functional substance therein. The method includes the steps of (a) putting the functional substance, lipid and water in a cylindrical container; and (b) producing the vesicles encapsulating the functional substance in lipid vesicles which comprise the lipid as a major component and which encapsulate the functional substance therein, by kneading the contents of the container with simultaneous rotational movement of the container around its center axis together with revolutionary movement of the container about a predetermined axis of revolution.
摘要:
A stator of an electric motor includes coil cores, bobbins and coils. The coil cores include six coil cores, which are arranged at equal angular intervals in a circumferential direction. The bobbins respectively cover outer peripheral surfaces of the coil cores, and the coils are respectively wound around outer peripheral surfaces of the bobbins. Among the six coils, each diametrically opposed two coils are electrically connected to each other through the corresponding connection line. Positioning members displace positions of the connection lines from one another, so that interference between the connection lines and interference between the connection line and the coils are limited.