摘要:
An object of the present invention is to find a novel pharmacological effect of a compound having an HDAC inhibitory effect. The compound having an HDAC inhibitory effect of the invention has an excellent effect of cell morphological change on trabecular meshwork cells and/or effect of intraocular pressure reduction, and is therefore useful as a preventive and/or therapeutic agent for a disease considered to be associated with aqueous humor circulation and/or intraocular pressure, particularly as a preventive and/or therapeutic agent for glaucoma or ocular hypertension.
摘要:
A method for treating glaucoma or ocular hypertension comprising administering to a patient a pharmacologically effective amount of a compound represented by the following (1) or a salt thereof: wherein X represents CH or N; R1 represents a hydrogen atom, a hydroxy group, a halogen atom, an alkyl group, an alkoxy group, a cycloalkyl group, a cycloalkoxy group, a (cycloalkyl)methoxy group, or R2 represents a hydrogen atom, an alkyl group, a cycloalkyl group, an alkylcarbonyl group or an alkyloxycarbonyl group; and Ra and Rb are the same or different and represent a hydrogen atom, a hydroxy group, a halogen atom, an alkyl group, an alkoxy group, a cycloalkyl group or a cycloalkoxy group.
摘要翻译:一种治疗青光眼或高眼压症的方法,其特征在于,向患者施用药理学有效量的下述(1)表示的化合物或其盐:其中,X表示CH或N; R1表示氢原子,羟基,卤素原子,烷基,烷氧基,环烷基,环烷氧基,(环烷基)甲氧基,或R2表示氢原子,烷基,环烷基 基团,烷基羰基或烷氧基羰基; R a和R b相同或不同,表示氢原子,羟基,卤素原子,烷基,烷氧基,环烷基或环烷氧基。
摘要:
A method of forming a wooden mold may include, but is not limited to, the following processes. A resin solution may be impregnated into at least one wood board thereby forming at least one resin-impregnated wood board. The resin solution may include a resin component. The resin component may include at least one water-soluble bifunctional acrylic resin and at least one trifunctional or higher-functional acrylic resin. The at least one resin-impregnated wood board may be deformed. The resin component in the at least one resin-impregnated wood board may be cured at the same time or after the at least one resin-impregnated wood board may be deformed.