-
公开(公告)号:US20080312435A1
公开(公告)日:2008-12-18
申请号:US11667728
申请日:2005-10-31
申请人: Shiuji Saito , Hiroshi Ohta , Tomoko Ishizaki , Mitsukane Yoshinaga , Makoto Tatsuzuki , Yuji Yokobori , Yasumitsu Tomishima , Aki Morita , Yoshihisa Toda , Kimiko Tokugawa , Ayaka Kaku , Tomomi Murakami , Hiromitsu Yoshimura , Shingo Sekine , Takao Yoshimizu
发明人: Shiuji Saito , Hiroshi Ohta , Tomoko Ishizaki , Mitsukane Yoshinaga , Makoto Tatsuzuki , Yuji Yokobori , Yasumitsu Tomishima , Aki Morita , Yoshihisa Toda , Kimiko Tokugawa , Ayaka Kaku , Tomomi Murakami , Hiromitsu Yoshimura , Shingo Sekine , Takao Yoshimizu
IPC分类号: C07D417/12 , C07D213/75 , C07D277/46 , C07D231/40 , C07D263/48
CPC分类号: C07D417/12 , C07D213/75 , C07D231/40 , C07D401/12 , C07D409/12 , C07D413/12
摘要: An imine compound represented by the formula: wherein A represents a heterocyclic group; R1, R2, an R3 each represent a hydrogen atom, a halogen atom, a C1-10 alkyl group optionally substituted with an aryl group(s) substituted with a halogen atom(s), a C3-10 cycloalkyl group, a C1-6 haloalkyl group, a C1-10 alkoxy group, etc.; R4 represents an optionally substituted C1-10 alkyl, C2-6 alkenyl, or aryl group; R5 represents a hydrogen atom, a C1-10 alkoxy group, a C1-6 haloalkyl group, an optionally substituted C1-10 alkyl or C2-6 alkenyl group, an optionally substituted aryl or heterocyclic group, etc.; W represents —CO—, —CO—CO—, —CO—NH—, —CS—NH—, or —SO2—, or a cannabinoid-receptor agonist comprising said imine compound as an active ingredient. The imine compound of the present invention has a cannabinoid-receptor agonist effect, and is useful as a therapeutic or prophylactic drug for pains and autoimmune diseases.
摘要翻译: 由下式表示的亚胺化合物:其中A表示杂环基; R 1,R 2,R 3各自表示氢原子,卤素原子,任选被被卤素原子取代的芳基取代的C 1-10烷基,C 3-10环烷基, 6卤代烷基,C1-10烷氧基等; R 4表示任选取代的C 1-10烷基,C 2-6烯基或芳基; R5表示氢原子,C1-10烷氧基,C1-6卤代烷基,任选取代的C 1-10烷基或C 2-6烯基,任选取代的芳基或杂环基等; W表示-CO-,-CO-CO-,-CO-NH-,-CS-NH-或-SO 2 - 或包含所述亚胺化合物作为活性成分的大麻素受体激动剂。 本发明的亚胺化合物具有大麻素受体激动剂作用,可用作疼痛和自身免疫疾病的治疗或预防药物。