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1.发明授权Method of immunizing humans against Salmonella typhi using a Vi-rEPA conjugate vaccine 失效使用Vi-rEPA结合疫苗免疫人类伤寒沙门氏菌的方法公开(公告)号：US07754227B2
公开(公告)日：2010-07-13
申请号：US11726304
申请日：2007-03-20
IPC分类号： A61K39/112
CPC分类号： A61K39/0275 , A61K2039/6037 , A61K2039/6068 , A61K2039/627 , C07K14/21 , C07K14/255 , Y02A50/482 , Y02A50/484
摘要： This invention relates to conjugates of the Vi polysaccharide of S. typhi with the carrier Pseudomonas aeruginosa recombinant exoprotein A (rEPA), and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, S. typhi bacterial infections. The conjugates, and compositions thereof, are useful as vaccines to induce serum antibodies against S. typhi and are useful to prevent and/or treat illnesses caused by S. typhi.
摘要翻译： 本发明涉及伤寒沙门氏菌的Vi多糖与载体铜绿假单胞菌重组外蛋白A（rEPA）的缀合物及其组合物，以及这些缀合物和/或其组合物用于在人体中诱导免疫原性应答的方法， 包括提供防治或减轻伤寒沙门菌细菌感染严重性的反应。 缀合物及其组合物可用作诱导针对伤寒沙雷氏菌的血清抗体的疫苗，并且可用于预防和/或治疗由伤寒沙门氏菌引起的疾病。
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2.发明授权Method of immunizing humans against Salmonella typhi using a Vi-rEPA conjugate vaccine 有权使用Vi-rEPA结合疫苗免疫人类伤寒沙门氏菌的方法公开(公告)号：US08202520B2
公开(公告)日：2012-06-19
申请号：US12790258
申请日：2010-05-28
IPC分类号： A61K39/385
CPC分类号： A61K39/0275 , A61K2039/6037 , A61K2039/6068 , A61K2039/627 , C07K14/21 , C07K14/255 , Y02A50/482 , Y02A50/484
摘要： This invention relates to conjugates of the Vi polysaccharide of S. typhi with the carrier Pseudomonas aeruginosa recombinant exoprotein A (rEPA), and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, S. typhi bacterial infections. The conjugates, and compositions thereof, are useful as vaccines to induce serum antibodies against S. typhi and are useful to prevent and/or treat illnesses caused by S. typhi.
摘要翻译： 本发明涉及伤寒沙门氏菌的Vi多糖与载体铜绿假单胞菌重组外蛋白A（rEPA）的缀合物及其组合物，以及这些缀合物和/或其组合物用于在人体中诱导免疫原性应答的方法， 包括提供防治或减轻伤寒沙门菌细菌感染严重性的反应。 缀合物及其组合物可用作诱导针对伤寒沙雷氏菌的血清抗体的疫苗，并且可用于预防和/或治疗由伤寒沙门氏菌引起的疾病。
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公开(公告)号：US07527797B1
公开(公告)日：2009-05-05
申请号：US10363618
申请日：2000-09-01
IPC分类号： A61K39/00 , A61K39/38 , A61K39/40 , A61K39/385 , A61K39/116 , A61K39/02 , A61K39/106 , A61K38/00 , A61K38/16 , A01N37/18 , C12P21/08 , C08H1/00 , C07K16/00
CPC分类号： A61K39/107 , A61K47/646
摘要： The invention pertains to conjugates of the capsular polysaccharide of Vibrio cholerae O139, or a structurally and/or immunologically related oligo- or poly-saccharide, and a carrier. These conjugates are useful as pharmaceutical compositions and/or vaccines to induce serum antibodies which have bactericidal (vibriocidal) activity against V. cholerae, in particular V. cholerae O139, and are useful to prevent, treat and/or reduce the severity of disease caused by V. cholerae infection, such as cholera. The present invention also relates to diagnostic tests for V. cholerae infection, and/or cholera caused by V. cholerae infection, using one or more of the oligo- or poly-saccharide-carrier conjugates or antibodies described above.
摘要翻译： 本发明涉及霍乱弧菌O139的荚膜多糖或结构和/或免疫相关的寡糖或多糖和载体的缀合物。 这些缀合物可用作药物组合物和/或疫苗以诱导对霍乱弧菌（特别是霍乱弧菌O139）具有杀菌（弧菌）活性）的血清抗体，并且可用于预防，治疗和/或降低引起的疾病的严重性 霍乱弧菌感染，如霍乱。 本发明还涉及使用一种或多种上述寡糖或多糖 - 载体缀合物或抗体的霍乱弧菌感染和/或由霍乱弧菌感染引起的霍乱的诊断测试。
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公开(公告)号：US08852605B2
公开(公告)日：2014-10-07
申请号：US11695735
申请日：2007-04-03
IPC分类号： A61K39/00 , A61K39/38 , A61K39/40 , A61K39/385 , A61K39/116 , A61K39/02 , A61K39/106 , A61K38/00 , A61K38/16 , A61K39/395 , A61K31/415 , A01N43/46
CPC分类号： A61K39/107 , A61K47/646
摘要： The disclosure pertains to conjugates of the capsular polysaccharide of Vibrio cholerae O139, or a structurally and/or immunologically related oligo- or poly-saccharide, and a carrier. These conjugates are useful as pharmaceutical compositions and/or vaccines to induce serum antibodies which have bactericidal (vibriocidal) activity against V. cholerae, in particular V. cholerae O139, and are useful to prevent, treat and/or reduce the severity of disease caused by V. cholerae infection, such as cholera. The present disclosure also relates to diagnostic tests for V. cholerae infection, and/or cholera caused by V. cholerae infection, using one or more of the oligo- or poly-saccharide-carrier conjugates or antibodies described above.
摘要翻译： 本公开涉及霍乱弧菌O139的荚膜多糖或结构和/或免疫相关的寡糖或多糖和载体的缀合物。 这些缀合物可用作药物组合物和/或疫苗以诱导对霍乱弧菌（特别是霍乱弧菌O139）具有杀菌（弧菌）活性）的血清抗体，并且可用于预防，治疗和/或降低引起的疾病的严重性 霍乱弧菌感染，如霍乱。 本公开还涉及使用一种或多种上述寡糖或多糖 - 载体缀合物或抗体的霍乱弧菌感染和/或由霍乱弧菌感染引起的霍乱的诊断测试。
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5.发明申请METHOD OF IMMUNIZING HUMANS AGAINST SALMONELLA TYPHI USING A VI-REPA CONJUGATE VACCINE 有权使用维生素C联合疫苗免疫沙门氏菌的人类免疫方法公开(公告)号：US20100239601A1
公开(公告)日：2010-09-23
申请号：US12790258
申请日：2010-05-28
IPC分类号： A61K39/385 , A61P31/04
CPC分类号： A61K39/0275 , A61K2039/6037 , A61K2039/6068 , A61K2039/627 , C07K14/21 , C07K14/255 , Y02A50/482 , Y02A50/484
摘要： This invention relates to conjugates of the Vi polysaccharide of S. typhi with the carrier Pseudomonas aeruginosa recombinant exoprotein A (rEPA), and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, S. typhi bacterial infections. The conjugates, and compositions thereof, are useful as vaccines to induce serum antibodies against S. typhi and are useful to prevent and/or treat illnesses caused by S. typhi.
摘要翻译： 本发明涉及伤寒沙门氏菌的Vi多糖与载体铜绿假单胞菌重组外蛋白A（rEPA）的缀合物及其组合物，以及这些缀合物和/或其组合物用于在人体中诱导免疫原性应答的方法， 包括提供防治或减轻伤寒沙门菌细菌感染严重性的反应。 缀合物及其组合物可用作诱导针对伤寒沙雷氏菌的血清抗体的疫苗，并且可用于预防和/或治疗由伤寒沙门氏菌引起的疾病。
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公开(公告)号：US06797275B1
公开(公告)日：2004-09-28
申请号：US09653433
申请日：2000-09-01
IPC分类号： A61K39112
CPC分类号： A61K39/0275 , A61K2039/6037 , A61K2039/6068 , A61K2039/627 , C07K14/21 , C07K14/255 , Y02A50/482 , Y02A50/484
摘要： This invention relates to conjugates of the Vi polysaccharide of S. typhi with the carrier Pseudomonas aeruginosa recombinant exoprotein A (rEPA), and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, S. typhi bacterial infections. The conjugates, and compositions thereof, are useful as vaccines to induce serum antibodies againt S. typhi and are useful to prevent and/or treat illnesses caused by S. typhi.
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公开(公告)号：US07247307B2
公开(公告)日：2007-07-24
申请号：US11015436
申请日：2004-12-16
申请人： Shousun Chen Szu , John B. Robbins , Edward Konadu, deceased , Yvonne Ageyman Konadu, legal representative
发明人： Shousun Chen Szu , John B. Robbins , Edward Konadu, deceased , Yvonne Ageyman Konadu, legal representative
IPC分类号： A61K39/108 , A61K39/385
CPC分类号： A61K39/0258 , A61K2039/6037 , Y02A50/474
摘要： This invention relates to conjugates of the O-specific polysaccharide of E. coli O157 with a carrier, and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in mammals, including responses which provide protection against, or reduce the severity of, bacterial infections. More particularly it relates to the use of polysaccharides containing the tetrasaccharide repeat unit: (→3)-α-DGalpNAc-(1→2)-α-D-PerpNAc-(1→3)-α-L-Fucp-(1→4)-β-D-Glcp-(1→), and conjugates thereof, to induce serum antibodies having bactericidal (killing) activity against hemolytic-uremic syndrome (HUS) causing E. coli, in particular E. coli O157. The conjugates, and compositions thereof, are useful as vaccines to induce serum antibodies which have bactericidal or bacteriostatic activity against E. coli, in particular E. coli O157, and are useful to prevent and/or treat illnesses caused by E. coli O157.The invention further relates to the antibodies which immunoreact with the O-specific polysaccharide of E. coli O157 and/or the carrier, that are induced by these conjugates and/or compositions thereof. The invention also relates to methods and kits using one or more of the polysaccharides, conjugates or antibodies described above.
摘要翻译： 本发明涉及大肠杆菌O157的O-特异性多糖与载体及其组合物的缀合物，以及这些缀合物和/或其组合物在哺乳动物中引发免疫原性应答的方法，包括提供保护的应答 反对或减轻细菌感染的严重性。 更具体地说，涉及使用含有四糖重复单元的多糖：（→3）-alpha-DGalpNAc-（1-> 2）-alpha-D-PerpNAc-（1-> 3）-alpha-L-Fucp - （1-> 4）-β-D-Glcp-（1->）及其缀合物，以诱导对引起大肠杆菌的溶血性尿毒综合征（HUS）具有杀菌（杀伤）活性的血清抗体，特别是E 大肠杆菌O157。 缀合物及其组合物可用作诱导对大肠杆菌特别是大肠杆菌O157具有杀菌或抑菌活性的血清抗体的疫苗，并且可用于预防和/或治疗由大肠杆菌O157引起的疾病。 本发明还涉及与这些缀合物和/或其组合物诱导的大肠杆菌O157和/或载体的O-特异性多糖免疫反应的抗体。 本发明还涉及使用上述一种或多种多糖，缀合物或抗体的方法和试剂盒。
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公开(公告)号：US08168195B2
公开(公告)日：2012-05-01
申请号：US12471049
申请日：2009-05-22
申请人： Shousun Chen Szu , John B. Robbins , Edward Konadu , Yvonne Ageyman Konadu, legal representative
发明人： Shousun Chen Szu , John B. Robbins , Edward Konadu
IPC分类号： A61K39/385
CPC分类号： A61K39/0258 , A61K2039/6037 , Y02A50/474
摘要： This invention relates to conjugates of the O-specific polysaccharide of E. coli O157 with a carrier, and compositions thereof, and to methods of using of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in mammals, including responses which provide protection against, or reduce the severity of, bacterial infections. More particularly it relates to the use of polysaccharides containing the tetrasaccharide repeat unit: (→3)-α-DGalpNAc-(1→2)-α-D-PerpNAc-(1→3)-α-L-Fucp-(1→4)-β-D-Glcp-(1→), and conjugates thereof, to induce serum antibodies having bactericidal (killing) activity against hemolytic-uremic syndrome (HUS) causing E. coli, in particular E. coli O157. The conjugates, and compositions thereof, are useful as vaccines to induce serum antibodies which have bactericidal or bacteriostatic activity against E. coli, in particular E. coli O157, and are useful to prevent and/or treat illnesses caused by E. coli O157.The invention further relates to the antibodies which immunoreact with the O-specific polysaccharide of E. coli O157 and/or the carrier, that are induced by these conjugates and/or compositions thereof. The invention also relates to methods and kits using one or more of the polysaccharides, conjugates or antibodies described above.
摘要翻译： 本发明涉及大肠杆菌O157的O-特异性多糖与载体及其组合物的缀合物，以及这些缀合物和/或其组合物在哺乳动物中引发免疫原性应答的方法，包括提供保护的应答 反对或减轻细菌感染的严重性。 更具体地说，涉及使用含有四糖重复单元的多糖：（→3）-α-DGalpNAc-（1→2）-α-D-PerpNAc-（1→3）-α-L-Fucp-（1 →4） - ＆bgr; -D-Glcp-（1→）及其缀合物，以诱导对引起大肠杆菌，特别是大肠杆菌O157的溶血性尿毒综合征（HUS）具有杀菌（杀伤）活性的血清抗体。 缀合物及其组合物可用作诱导对大肠杆菌特别是大肠杆菌O157具有杀菌或抑菌活性的血清抗体的疫苗，并且可用于预防和/或治疗由大肠杆菌O157引起的疾病。 本发明还涉及与这些缀合物和/或其组合物诱导的大肠杆菌O157和/或载体的O-特异性多糖免疫反应的抗体。 本发明还涉及使用上述一种或多种多糖，缀合物或抗体的方法和试剂盒。
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公开(公告)号：US20090232840A1
公开(公告)日：2009-09-17
申请号：US12471049
申请日：2009-05-22
IPC分类号： A61K39/385 , C07K16/12
CPC分类号： A61K39/0258 , A61K2039/6037 , Y02A50/474
摘要： This invention relates to conjugates of the O-specific polysaccharide of E. coli O157 with a carrier, and compositions thereof, and to methods of using of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in mammals, including responses which provide protection against, or reduce the severity of, bacterial infections. More particularly it relates to the use of polysaccharides containing the tetrasaccharide repeat unit: (→3)-α-DGalpNAc-(1→2)-α-D-PerpNAc-(1→3)-α-L-Fucp-(1→4)-β-D-Glcp-(1→), and conjugates thereof, to induce serum antibodies having bactericidal (killing) activity against hemolytic-uremic syndrome (HUS) causing E. coli, in particular E. coli O157. The conjugates, and compositions thereof, are useful as vaccines to induce serum antibodies which have bactericidal or bacteriostatic activity against E. coli, in particular E. coli O157, and are useful to prevent and/or treat illnesses caused by E. coli O157.The invention further relates to the antibodies which immunoreact with the O-specific polysaccharide of E. coli O157 and/or the carrier, that are induced by these conjugates and/or compositions thereof. The invention also relates to methods and kits using one or more of the polysaccharides, conjugates or antibodies described above.
摘要翻译： 本发明涉及大肠杆菌O157的O-特异性多糖与载体及其组合物的缀合物，以及这些缀合物和/或其组合物在哺乳动物中引发免疫原性应答的方法，包括提供保护的应答 反对或减轻细菌感染的严重性。 更具体地说，涉及使用含有四糖重复单元的多糖：（→3）-alpha-DGalpNAc-（1-> 2）-alpha-D-PerpNAc-（1-> 3）-alpha-L-Fucp - （1-> 4）-β-D-Glcp-（1->）及其缀合物，以诱导对引起大肠杆菌的溶血性尿毒综合征（HUS）具有杀菌（杀伤）活性的血清抗体，特别是E 大肠杆菌O157。 缀合物及其组合物可用作诱导对大肠杆菌特别是大肠杆菌O157具有杀菌或抑菌活性的血清抗体的疫苗，并且可用于预防和/或治疗由大肠杆菌O157引起的疾病。 本发明还涉及与这些缀合物和/或其组合物诱导的大肠杆菌O157和/或载体的O-特异性多糖免疫反应的抗体。 本发明还涉及使用上述一种或多种多糖，缀合物或抗体的方法和试剂盒。
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10.发明授权Methods of using Bacillus anthracis protective antigen sequences for vaccination 有权使用炭疽芽孢杆菌保护性抗原序列进行疫苗接种的方法公开(公告)号：US08703150B2
公开(公告)日：2014-04-22
申请号：US13244060
申请日：2011-09-23
CPC分类号： C07H21/04 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/32
摘要： The invention relates to improved methods of producing and recovering B. anthracis protective antigen (PA), especially modified PA which is protease resistant, and to methods of using of these PAs or nucleic acids encoding these PAs for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, B. anthracis bacterial infections and which are useful to prevent and/or treat illnesses caused by B. anthracis, such as inhalation anthrax, cutaneous anthrax and gastrointestinal anthrax.
摘要翻译： 本发明涉及生产和回收炭疽芽孢杆菌保护性抗原（PA），特别是蛋白酶抗性的经修饰的PA的改进方法，以及使用这些PA或编码这些PA的核酸在人体中引发免疫原性应答的方法，包括 对炭疽杆菌细菌感染提供保护或降低其严重程度的反应，其可用于预防和/或治疗由炭疽芽孢杆菌引起的疾病，例如吸入性炭疽，皮肤炭疽和胃肠道炭疽。
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