Method for producing highly pure tetrasodium salt of ethylenediaminetetraacetic acid
    3.
    发明授权
    Method for producing highly pure tetrasodium salt of ethylenediaminetetraacetic acid 有权
    乙二胺四乙酸高纯四钠盐的制备方法

    公开(公告)号:US06297397B1

    公开(公告)日:2001-10-02

    申请号:US09555584

    申请日:2000-06-01

    申请人: Cheong-Song Choi

    发明人: Cheong-Song Choi

    IPC分类号: C04C22900

    摘要: A method for producing highly purified crystals of tetrasodium. Salt of ethylenediaminetetraacetic acid including reacting ethylene diamine, NaCN and formalin in the presence of an alkali to yield a solution containing EDTA4Na and impurities. This solution is subjected to crystallization over a solvent to form EDTA4Na crystals. The solvent is a mixture of methanol and an alcohol of either ethanol or propanol. The methanol has a ratio by weight to the alcohol of 1:0.43-4.0. The EDTA4Na crystals are then recovered after subjecting the solution to crystallization.

    摘要翻译: 一种生产高纯度四钠晶体的方法。 乙二胺四乙酸的盐包括在碱存在下使乙二胺,NaCN和福尔马林反应,得到含有EDTA4Na和杂质的溶液。 将该溶液在溶剂上结晶形成EDTA4Na晶体。 溶剂是甲醇和乙醇或丙醇的醇的混合物。 甲醇的重量比为1:0.43-4.0。 然后在使溶液结晶后,回收EDTA4Na晶体。

    Crystallization of &agr;-L-aspartyl-L-phenylalanine methyl ester
    4.
    发明授权
    Crystallization of &agr;-L-aspartyl-L-phenylalanine methyl ester 失效
    α-L-天冬氨酰-L-苯丙氨酸甲酯的结晶

    公开(公告)号:US06657073B1

    公开(公告)日:2003-12-02

    申请号:US09653662

    申请日:2000-09-01

    申请人: Cheong-Song Choi

    发明人: Cheong-Song Choi

    IPC分类号: C07C22900

    CPC分类号: C07K5/0613

    摘要: The present invention provides a novel process for the crystallization of &agr;-L-aspartyl-L-phenylalanine methyl ester crystals wherein initial nucleation and initial crystal growth is conducted in a controlled manner in a metastable supersaturated solution, followed by further crystal growth via a cooling crystallization step. The process disclosed herein can be performed in an industrial scale.

    摘要翻译: 本发明提供了一种用于结晶α-L-天冬氨酰基-L-苯丙氨酸甲酯晶体的新方法,其中初始成核和初始晶体生长以可控的方式在亚稳态过饱和溶液中进行,随后通过冷却进一步晶体生长 结晶步骤。 本文公开的方法可以以工业规模进行。