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    INDAZOLE COMPOUNDS AND METHODS OF USE THEREOF
    7.
    发明申请
    INDAZOLE COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
    INDAZOLE化合物及其使用方法

    公开(公告)号：US20090099178A1

    公开(公告)日：2009-04-16

    申请号：US12340129

    申请日：2008-12-19

    申请人： Shripad S. Bhagwat ,  Yoshitaka Satoh ,  Steven T. Sakata ,  Chris A. Buhr ,  Ronald Albers ,  John Sapienza ,  Veronique Plantevin ,  Qi Chao ,  Kiran Sahasrabudhe ,  Rachel Stengone ,  Rama K. Narla

    发明人： Shripad S. Bhagwat ,  Yoshitaka Satoh ,  Steven T. Sakata ,  Chris A. Buhr ,  Ronald Albers ,  John Sapienza ,  Veronique Plantevin ,  Qi Chao ,  Kiran Sahasrabudhe ,  Rachel Stengone ,  Rama K. Narla

    IPC分类号： A61K31/5377 ,  C07D403/10 ,  C07D413/14 ,  A61P35/04 ,  A61P25/00 ,  C07D403/14 ,  A61K31/416

    CPC分类号： C07D403/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14

    摘要： This invention is directed to Indazole Compounds or pharmaceutically acceptable salts, solvates and hydrates thereof. The Indazole Compounds have utility in the treatment or prevention of a wide range of diseases and disorders that are responsive to the inhibition, modulation or regulation of kinases, such as inflammatory diseases, abnormal angiogenesis and diseases related thereto, cancer, atherosclerosis, a cardiovascular disease, a renal disease, an autoimmune condition, macular degeneration, disease-related wasting, an asbestos-related condition, pulmonary hypertension, diabetes, obesity, pain and others. Thus, methods of treating or preventing such diseases and disorders are also disclosed, as are pharmaceutical compositions comprising one or more of the Indazole Compounds. This invention is based, in part, upon the discovery of a novel class of 5-triazolyl substituted indazole molecules that have potent activity with respect to the modulation of protein kinases. Thus, the invention encompasses orally active molecules as well as parenterally active molecules which can be used at lower doses or serum concentrations for treating diseases or disorders associated with protein kinase signal transduction.

    摘要翻译： 本发明涉及吲唑化合物或其药学上可接受的盐，溶剂化物和水合物。 吲唑化合物可用于治疗或预防对抑制，调节或调节激酶（例如炎性疾病，异常血管生成和与之相关的疾病，癌症，动脉粥样硬化，心血管疾病）的各种疾病和病症 肾脏疾病，自身免疫性疾病，黄斑变性，疾病相关性消耗，石棉相关病症，肺动脉高压，糖尿病，肥胖，疼痛等。 因此，还公开了治疗或预防这些疾病和病症的方法，以及包含一种或多种吲唑化合物的药物组合物。 本发明部分基于发现关于蛋白激酶调节具有强力活性的新一类5-三唑基取代的吲唑分子。 因此，本发明包括口服活性分子以及可以以较低剂量或血清浓度用于治疗与蛋白激酶信号转导相关的疾病或病症的肠胃外活性分子。

    Platinum (II) antitumor compounds
    10.
    发明授权
    Platinum (II) antitumor compounds 失效
    铂（II）抗肿瘤化合物

    公开(公告)号：US06737537B2

    公开(公告)日：2004-05-18

    申请号：US10146971

    申请日：2002-05-15

    申请人： Faith M. Uckun ,  Rama K. Narla

    发明人： Faith M. Uckun ,  Rama K. Narla

    IPC分类号： C07F1500

    CPC分类号： C07F15/0093

    摘要： The present invention describes platinum (II) compounds and compositions useful for treating a subject with a tumor and/or inducing apoptosis in a population of cells. The present invention also describes pharmaceutical compositions containing the aforementioned inventive compound(s) in combination with a pharmaceutically acceptable carrier. Additionally, the invention further provides a method of inducing apoptosis in a population of cells and a method of treating a subject with a tumor, wherein the method comprises administering to the subject a therapeutically effective amount of the aforementioned compound(s) or composition(s).

    摘要翻译： 本发明描述了铂（II）化合物和用于治疗患有肿瘤的受试者和/或诱导细胞群中凋亡的组合物。 本发明还描述了含有上述本发明化合物与药学上可接受的载体组合的药物组合物。 另外，本发明还提供了诱导细胞群中细胞凋亡的方法和用肿瘤治疗受试者的方法，其中所述方法包括向受试者施用治疗有效量的上述化合物或组合物 ）。