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    Efficient production of heterologous proteins using mannosyl transferase inhibitors
    3.
    发明授权
    Efficient production of heterologous proteins using mannosyl transferase inhibitors 有权
    使用甘露糖基转移酶抑制剂有效生产异源蛋白

    公开(公告)号：US08309325B2

    公开(公告)日：2012-11-13

    申请号：US12993716

    申请日：2009-05-18

    申请人： Ranjit Desai ,  Lihu Yang

    发明人： Ranjit Desai ,  Lihu Yang

    IPC分类号： C12P21/02 ,  C07D277/36

    CPC分类号： C12P21/005 ,  C07D277/36 ,  C12P21/02

    摘要： Compounds and methods are described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of certain benzylidene thiazolidinediones inhibitors of Pmt-mediated O-linked glycosylation.

    摘要翻译： 描述了用于生产具有降低量的O-连接糖基化的蛋白质组合物的化合物和方法。 该方法包括在某些亚苄基噻唑烷二酮类Pmt介导的O-连接糖基化抑制剂存在下培养的细胞中产生蛋白质。

    EFFICIENT PRODUCTION OF HETEROLOGOUS PROTEINS USING MANNOSYL TRANSFERASE INHIBITORS
    4.
    发明申请
    EFFICIENT PRODUCTION OF HETEROLOGOUS PROTEINS USING MANNOSYL TRANSFERASE INHIBITORS 有权
    使用芒硝转移酶抑制剂有效生产异位蛋白

    公开(公告)号：US20110076721A1

    公开(公告)日：2011-03-31

    申请号：US12993716

    申请日：2009-05-18

    申请人： Ranjit Desai ,  Lihu Yang

    发明人： Ranjit Desai ,  Lihu Yang

    IPC分类号： C12P21/02 ,  C07D277/36

    CPC分类号： C12P21/005 ,  C07D277/36 ,  C12P21/02

    摘要： Compounds and methods are described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of certain benzylidene thiazolidine-diones inhibitors of Pmt-mediated O-linked glycosylation.

    摘要翻译： 描述了用于生产具有降低量的O-连接糖基化的蛋白质组合物的化合物和方法。 该方法包括在存在Pmt介导的O-连接糖基化的某些亚苄基噻唑烷二酮抑制剂存在下培养的细胞中产生蛋白质。

    Efficient production of heterologous proteins using mannosyl transferase inhibitors
    5.
    发明授权
    Efficient production of heterologous proteins using mannosyl transferase inhibitors 有权
    使用甘露糖基转移酶抑制剂有效生产异源蛋白

    公开(公告)号：US08765409B2

    公开(公告)日：2014-07-01

    申请号：US13588022

    申请日：2012-08-17

    申请人： Ranjit Desai ,  Lihu Yang

    发明人： Ranjit Desai ,  Lihu Yang

    IPC分类号： C12P21/00 ,  C07D277/36

    CPC分类号： C12P21/005 ,  C07D277/36 ,  C12P21/02

    摘要： Compounds and methods are described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of certain benzylidene thiazolidinediones inhibitors of Pmt-mediated O-linked glycosylation.

    摘要翻译： 描述了用于生产具有降低量的O-连接糖基化的蛋白质组合物的化合物和方法。 该方法包括在某些亚苄基噻唑烷二酮类Pmt介导的O-连接糖基化抑制剂存在下培养的细胞中产生蛋白质。

    Method and apparatus using intensity gradients for visual identification of 2D matrix symbols
    6.
    发明授权
    Method and apparatus using intensity gradients for visual identification of 2D matrix symbols 有权
    使用强度梯度进行二维矩阵符号视觉识别的方法和装置

    公开(公告)号：US06941026B1

    公开(公告)日：2005-09-06

    申请号：US09592839

    申请日：2000-06-13

    申请人： Sateesh Gopalakrishna Nadabar ,  Ranjit Desai

    发明人： Sateesh Gopalakrishna Nadabar ,  Ranjit Desai

    IPC分类号： G06K7/14 ,  G06K9/40 ,  G06K9/56

    CPC分类号： G06K7/1443 ,  G06K7/14

    摘要： Visual information regarding intensity and intensity-based gradient information is used in a multi-step process for accurately locating and decoding an encoded visual symbol matrix. A symbol is preprocessed with filtering and morphology. A set of coarse locations of candidate symbols is filtered according to coarse geometric criteria to determine which image locations are most viable. Depending upon the symbol type, and information about the edges of the symbols, additional symbol-specific filtering and refinements can be applied or skipped. For 2D matrices filtering according to intensity variance criteria is followed by an edge-locating refinement and by identifying finder patterns and timing patterns. Once finder patterns and timing patterns are precisely located, the data region is decoded. Where a data region does not decode validly, another pass is run, using the non-morphed image, resulting in an overall saving of time, as rejections may require operator intervention.

    摘要翻译： 关于基于强度和强度的梯度信息的视觉信息被用于准确地定位和解码编码的视觉符号矩阵的多步骤过程中。 符号被过滤和形态预处理。 根据粗略几何标准过滤一组候选符号的粗略位置，以确定哪些图像位置是最可行的。 根据符号类型和关于符号边缘的信息，可以应用或跳过附加的符号特定过滤和细化。 对于根据强度方差标准的2D矩阵滤波，其后跟边缘定位细化，并通过识别取景器图案和时序图案。 一旦查找器图案和定时模式被精确地定位，则对数据区进行解码。 在数据区域无法有效解码的情况下，使用未变形的图像运行另一遍，导致总体节省时间，因为拒绝可能需要操作员干预。

    Fast image retrieval using multi-scale edge representation of images
    8.
    发明授权
    Fast image retrieval using multi-scale edge representation of images 失效
    使用图像的多尺度边缘表示的快速图像检索

    公开(公告)号：US06072904A

    公开(公告)日：2000-06-06

    申请号：US2097

    申请日：1997-12-31

    申请人： Ranjit Desai ,  Mohamed Abdel-Mottaleb

    发明人： Ranjit Desai ,  Mohamed Abdel-Mottaleb

    IPC分类号： G06T1/00 ,  G06F17/30 ,  G06T7/00 ,  G06T7/60 ,  G06K9/54 ,  G06K9/62 ,  H04N1/00

    CPC分类号： G06F17/30259 ,  Y10S707/99932 ,  Y10S707/99933 ,  Y10S707/99943 ,  Y10S707/99945

    摘要： An image retrieval system for retrieving images from a data base in dependence upon the degree of correspondence with a user-input target image. The target image and each image in the data base are characterized by a vector of edge characteristics within each image. Retrieval is effected by a comparison of the characteristic vectors, rather than a comparison of the images themselves. To optimize performance, a set of characteristic vectors, at different levels of abstraction of the image, are associated with each data base image; images which are similar to the target image, at any level of abstraction, are retrieved. To further optimize the speed of search, the data base is partitioned into clusters, and the search is limited to the cluster most similar to the target image.

    摘要翻译： 一种用于根据与用户输入目标图像的对应程度从数据库中检索图像的图像检索系统。 数据库中的目标图像和每个图像的特征在于每个图像内的边缘特征向量。 通过比较特征向量而不是图像本身的比较来实现检索。 为了优化性能，在图像的抽象级别的一组特征向量与每个数据库图像相关联; 检索与任何抽象级别的目标图像类似的图像。 为了进一步优化搜索速度，数据库被划分成簇，搜索限于与目标图像最相似的簇。

    Ppar alpha selective compounds for the treatment of dyslipidemia and other lipid disorders
    9.
    发明申请
    Ppar alpha selective compounds for the treatment of dyslipidemia and other lipid disorders 失效
    Pparα选择性化合物用于治疗血脂异常和其他脂质障碍

    公开(公告)号：US20060089404A1

    公开(公告)日：2006-04-27

    申请号：US10522646

    申请日：2003-07-25

    申请人： Ranjit Desai ,  Soumya Sahoo

    发明人： Ranjit Desai ,  Soumya Sahoo

    IPC分类号： C07D311/04 ,  A61K31/353

    CPC分类号： C07D311/04 ,  A61K45/06 ,  C07D311/16 ,  C07D311/18 ,  C07D311/58

    摘要： A class of chromane and chromene compounds having the structure shown below and pharmaceutically acceptable salts thereof are useful as therapeutic compounds, particularly in the treatment and control of hyperlipidemia, hypercholesterolemia, dyslipidemia, and other lipid disorders, and in delaying the onset of or reducing the risk of conditions and sequelae that are associated with these diseases, such as atherosclerosis.

    摘要翻译： 具有以下所示结构的一系列色烯和色烯化合物及其药学上可接受的盐可用作治疗化合物，特别是用于治疗和控制高脂血症，高胆固醇血症，血脂异常和其它脂质疾病，并延迟其发作或减少 与这些疾病相关的病症和后遗症的风险，如动脉粥样硬化。

    Process to prepare dihydropyridine and derivatives thereof
    10.
    发明授权
    Process to prepare dihydropyridine and derivatives thereof 失效
    二氢吡啶及其衍生物的制备方法

    公开(公告)号：US5977369A

    公开(公告)日：1999-11-02

    申请号：US579758

    申请日：1995-12-28

    申请人： Ranjit Desai ,  Daniel Alfonso Aguilar ,  Mohammad Aslam ,  Nicholas Gallegos

    发明人： Ranjit Desai ,  Daniel Alfonso Aguilar ,  Mohammad Aslam ,  Nicholas Gallegos

    IPC分类号： C07D211/90 ,  C07D211/86

    CPC分类号： C07D211/90

    摘要： A novel process is disclosed for the preparation of dihydropyridine compounds and derivatives thereof, and more particularly felodipine. The process to prepare felodipine involves a two step procedure condensing 2,3-dichlorobenzaldehyde with methyl acetoacetate in the presence of a catalyst system. The resultant benzylidine intermediate is sequentially reacted with ethyl aminocrotonate to provide felodipine. The novelty of the present invention resides in part on (1) a new catalyst system not previously disclosed for the preparation of felodipine, (2) the absence of acid(s), (3) the control of reaction conditions to yield lower amounts of unreacted aldehyde compared to known reactions, (4) a simplified purification process, and (5) formation of negligible quantities of symmetrical diester byproducts.

    摘要翻译： 公开了制备二氢吡啶化合物及其衍生物，更特别是非洛地平的新方法。 制备非洛地平的方法涉及在催化剂体系存在下将2,3-二氯苯甲醛与乙酰乙酸甲酯缩合的两步法。 将所得的苄基中间体与氨基巴豆酸乙酯依次反应以提供非洛地平。 本发明的新颖性部分在于（1）以前未公开制备非洛地平的新催化剂体系，（2）不存在酸，（3）控制反应条件以产生较低量的 未反应的醛与已知的反应相比，（4）简化的纯化过程，和（5）形成可忽略量的对称的二酯副产物。