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    METHODS AND SYSTEMS FOR ENDOBRONCHIAL DIAGNOSTICS
    1.
    发明申请
    METHODS AND SYSTEMS FOR ENDOBRONCHIAL DIAGNOSTICS 审中-公开
    内分泌诊断的方法与系统

    公开(公告)号：US20110295141A1

    公开(公告)日：2011-12-01

    申请号：US12954499

    申请日：2010-11-24

    申请人： Srikanth Radhakrishnan ,  Ryan Olivera ,  Niyazi Beyhan ,  Surag Mantri ,  Lutz Freitag

    发明人： Srikanth Radhakrishnan ,  Ryan Olivera ,  Niyazi Beyhan ,  Surag Mantri ,  Lutz Freitag

    IPC分类号： A61B5/08

    CPC分类号： A61B5/082

    摘要： A method for assessing lung function in a patient is disclosed. The method comprises isolating a lung compartment. Thereafter, in one embodiment, an inhaled gas of known composition is introduced into the lung and compared to the composition of the exhaled gas. Alternatively, accumulated CO2 content is measured within the isolated lung compartment over time, and compared to a baseline CO2 content. Alternatively, a change in pressure of an isolated lung compartment may be monitored. Alternatively, the magnitude of the range of CO2 values in an isolated lung compartment can be compared to a predetermined threshold. Any of the results obtained via these alternative embodiments may be used to determine lung function.

    摘要翻译： 公开了一种用于评估患者的肺功能的方法。 该方法包括分离肺隔室。 此后，在一个实施方案中，将已知组合物的吸入气体引入肺中并与呼出气体的组成进行比较。 或者，随着时间的推移在隔离的肺隔室内测量累积的CO 2含量，并与基线CO 2含量进行比较。 或者，可以监测隔离的肺隔室的压力变化。 或者，可以将隔离的肺隔室中的CO 2值的范围的大小与预定阈值进行比较。 通过这些替代实施方案获得的任何结果可用于确定肺功能。

    GASTRO-INTESTINLAL COMPRESSION DEVICE
    3.
    发明申请
    GASTRO-INTESTINLAL COMPRESSION DEVICE 有权
    GASTRO-INTESTINLAL压缩装置

    公开(公告)号：US20120065651A1

    公开(公告)日：2012-03-15

    申请号：US13186429

    申请日：2011-07-19

    申请人： Surag Mantri ,  Hoang Nguyen ,  Niyazi Beyhan

    发明人： Surag Mantri ,  Hoang Nguyen ,  Niyazi Beyhan

    IPC分类号： A61B17/11

    CPC分类号： A61B17/1114 ,  A61B2017/00818 ,  A61B2017/1132 ,  A61F5/0076 ,  A61F2002/044 ,  A61F2002/045

    摘要： Devices, methods, and systems for treating Type-2 Diabetes and/or obesity by facilitating the delivery of under-digested nutrients within the gastro-intestinal tract without substantial tissue removal are disclosed. In one aspect, the gastro-intestinal tract of a patient is modified by a gastro-intestinal treatment device comprising an elongate element configured to extend within the gastro-intestinal tract, a first attachment element and a second attachment element disposed on the elongate element, wherein the first attachment element and the second attachment element are configured to attach to the gastro-intestinal tract such that a portion of the gastro-intestinal tract is compressed between the first and the second attachment elements. The length of the gastro-intestinal tract modified by the device is effectively shortened, and its surface area is reduced.

    摘要翻译： 公开了通过促进胃肠道内消化不良的营养物质的递送而不需要大量去除组织来治疗2型糖尿病和/或肥胖症的装置，方法和系统。 在一个方面，患者的胃肠道由胃肠治疗装置改变，所述胃肠治疗装置包括构造成在胃肠道内延伸的细长元件，设置在细长元件上的第一附接元件和第二附接元件， 其中所述第一附接元件和所述第二附接元件构造成附接到胃肠道，使得胃肠道的一部分在第一和第二附接元件之间被压缩。 通过该装置修改的胃肠道的长度被有效地缩短，并且其表面积减小。

    DEVICES AND METHODS FOR SAFELY ACCESSING BONE MARROW AND OTHER TISSUES
    4.
    发明申请
    DEVICES AND METHODS FOR SAFELY ACCESSING BONE MARROW AND OTHER TISSUES 审中-公开
    用于安全地接受骨髓和其他组织的装置和方法

    公开(公告)号：US20100152616A1

    公开(公告)日：2010-06-17

    申请号：US12699847

    申请日：2010-02-03

    申请人： Niyazi Beyhan ,  Surag Mantri ,  Hoang Nguyen

    发明人： Niyazi Beyhan ,  Surag Mantri ,  Hoang Nguyen

    IPC分类号： A61B10/00

    CPC分类号： A61B10/025

    摘要： A device for safely accessing bone marrow and other tissues is disclosed. Such device comprises a needle assembly, a sensor mechanism, and an actuator configured to engage with the needle assembly via the sensor mechanism to advance a tissue penetrable needle through a first tissue region and into a second tissue region. In one aspect, the first tissue region is a bone cortex and the second tissue region is a bone marrow cavity. The sensor mechanism is configured to disengage the actuator from the needle once the needle has crossed the first tissue region (e.g., bone cortex) into the second tissue region (e.g., bone marrow cavity), thereby preventing the needle from advancing further into the second tissue region. In one aspect, the sensor mechanism is mechanical and comprises a pin assembly comprising a spring-loaded pin that extends through the needle. The pin assembly is configured such that advancement of the distal tip of the spring-loaded pin past the distal tip of the needle causes the actuator to disengage from the needle. The actuator is a rotatable actuator. A catheter-based embodiment of the device can be inserted in body passageways to access tissue internally within the body.

    摘要翻译： 公开了一种用于安全进入骨髓和其他组织的装置。 这种装置包括针组件，传感器机构和致动器，其构造成经由传感器机构与针组件接合，以将组织穿透针推进穿过第一组织区域并进入第二组织区域。 在一个方面，第一组织区域是骨皮质，第二组织区域是骨髓腔。 一旦针已经穿过第一组织区域（例如，骨皮质）进入第二组织区域（例如，骨髓腔），传感器机构构造成使致动器与针脱离，从而防止针进一步进入第二组织区域 组织区域。 在一个方面，传感器机构是机械的并且包括销组件，其包括延伸穿过针的弹簧加载销。 销组件被构造成使得弹簧加载的销的远端顶端超过针的远端使得致动器与针脱离。 致动器是可旋转的致动器。 该装置的基于导管的实施例可以插入身体通道中以在体内内部进入组织。

    Gastro-intestinal compression device
    5.
    发明授权
    Gastro-intestinal compression device 有权
    胃肠压缩装置

    公开(公告)号：US08870807B2

    公开(公告)日：2014-10-28

    申请号：US13186429

    申请日：2011-07-19

    申请人： Surag Mantri ,  Hoang Nguyen ,  Niyazi Beyhan

    发明人： Surag Mantri ,  Hoang Nguyen ,  Niyazi Beyhan

    IPC分类号： A61F2/04 ,  A61M5/00 ,  A61B17/11 ,  A61F5/00 ,  A61B17/00

    CPC分类号： A61B17/1114 ,  A61B2017/00818 ,  A61B2017/1132 ,  A61F5/0076 ,  A61F2002/044 ,  A61F2002/045

    摘要： Devices, methods, and systems for treating Type-2 Diabetes and/or obesity by facilitating the delivery of under-digested nutrients within the gastro-intestinal tract without substantial tissue removal are disclosed. In one aspect, the gastro-intestinal tract of a patient is modified by a gastro-intestinal treatment device comprising an elongate element configured to extend within the gastro-intestinal tract, a first attachment element and a second attachment element disposed on the elongate element, wherein the first attachment element and the second attachment element are configured to attach to the gastro-intestinal tract such that a portion of the gastro-intestinal tract is compressed between the first and the second attachment elements. The length of the gastro-intestinal tract modified by the device is effectively shortened, and its surface area is reduced.

    摘要翻译： 公开了通过促进胃肠道内消化不良的营养物质的递送而不需要大量去除组织来治疗2型糖尿病和/或肥胖症的装置，方法和系统。 在一个方面，患者的胃肠道由胃肠治疗装置改变，所述胃肠治疗装置包括构造成在胃肠道内延伸的细长元件，设置在细长元件上的第一附接元件和第二附接元件， 其中所述第一附接元件和所述第二附接元件构造成附接到胃肠道，使得胃肠道的一部分在第一和第二附接元件之间被压缩。 通过该装置修改的胃肠道的长度被有效地缩短，并且其表面积减小。

    LOCAL LUNG MEASUREMENT AND TREATMENT
    6.
    发明申请
    LOCAL LUNG MEASUREMENT AND TREATMENT 审中-公开
    当地的肺部测量和治疗

    公开(公告)号：US20110301483A1

    公开(公告)日：2011-12-08

    申请号：US12963412

    申请日：2010-12-08

    申请人： Niyazi Beyhan ,  Srikanth Radhakrishnan

    发明人： Niyazi Beyhan ,  Srikanth Radhakrishnan

    IPC分类号： A61B5/097 ,  A61B5/091 ,  A61B5/08

    CPC分类号： A61B5/082 ,  A61B5/0803 ,  A61B5/6853

    摘要： A method of determining potential treatment sites in a diseased lung is disclosed, in which an assessment catheter is introduced into a lung passageway. The catheter has a distal portion comprising an occluding member and a proximal portion configured to operatively mate with an external console. The catheter is used to identify one or more assessment sites within the airways of the lung. At each assessment site, at least one physiological, anatomical or biological characteristic is determined. A characteristic score for each assessment site is calculated based on a predetermined algorithm; and a treatment is determined based on the scores of the assessment sites. The algorithm takes into account several parameters including the disease characteristics as well as the number and proximity of each assessment site to at least one of the diseased regions. The method envisages treatment of emphysema, asthma or bronchopleural leak.

    摘要翻译： 公开了一种确定患病肺中潜在治疗部位的方法，其中将评估导管引入肺通道。 该导管具有远端部分，该远端部分包括封闭构件和配置成与外部控制台可操作地配合的近端部分。 导管用于识别肺气道内的一个或多个评估部位。 在每个评估部位，确定至少一个生理，解剖或生物特征。 基于预定算法计算每个评估点的特征得分; 并且基于评估地点的分数来确定治疗。 该算法考虑了几个参数，包括疾病特征以及每个评估位点与至少一个患病区域的数量和接近程度。 该方法设想治疗肺气肿，哮喘或支气管胸膜泄漏。

    Imaging catheter and methods of use for ultrasound-guided ablation
    9.
    发明授权
    Imaging catheter and methods of use for ultrasound-guided ablation 有权
    成像导管和超声引导消融的使用方法

    公开(公告)号：US06315732B1

    公开(公告)日：2001-11-13

    申请号：US09357378

    申请日：1999-07-20

    申请人： Veijo T. Suorsa ,  W. Martin Belef ,  Niyazi Beyhan ,  Donald S. Mamayek

    发明人： Veijo T. Suorsa ,  W. Martin Belef ,  Niyazi Beyhan ,  Donald S. Mamayek

    IPC分类号： A61B800

    CPC分类号： A61B8/12 ,  A61B8/0841 ,  A61B8/445 ,  A61B8/4461

    摘要： The present invention provides ultrasound imaging catheters, systems and methods for their use which will be particularly useful to monitor the positioning of ablation catheters. In one embodiment, an imaging catheter (10) includes a catheter body (11) having a distal end (12), a proximal end (14) and a longitudinal axis (16). A transducer (20) is rotatably coupled to the distal end. The transducer has an axis of rotation (24) that is at a non-zero angle relative to the catheter body longitudinal axis. Such a configuration provides an exemplary side-looking imaging catheter.

    摘要翻译： 本发明提供超声成像导管，其使用的系统和方法，其将特别有用于监测消融导管的定位。 在一个实施例中，成像导管（10）包括具有远端（12），近端（14）和纵向轴线（16）的导管主体（11）。 换能器（20）可旋转地联接到远端。 换能器具有相对于导管主体纵向轴线非零角度的旋转轴线（24）。 这种配置提供了示例性的侧视成像导管。

    Driveable catheter systems and methods
    10.
    发明申请
    Driveable catheter systems and methods 有权
    可驱动的导管系统和方法

    公开(公告)号：US20060084911A1

    公开(公告)日：2006-04-20

    申请号：US11254234

    申请日：2005-10-18

    申请人： W. Belef ,  John Ream ,  Thomas Moore ,  Steven Roe ,  Jeffrey Jones ,  Niyazi Beyhan ,  Arcadi Elbert

    发明人： W. Belef ,  John Ream ,  Thomas Moore ,  Steven Roe ,  Jeffrey Jones ,  Niyazi Beyhan ,  Arcadi Elbert

    IPC分类号： A61M31/00

    CPC分类号： A61B8/12 ,  A61B1/0016 ,  A61B8/4209 ,  A61B8/4461 ,  A61B46/10 ,  A61M25/0113 ,  A61M2025/0008

    摘要： The system (2) includes a catheter drive unit (22) and a catheter (24) extending therefrom movably mounted to a catheter drive sled (26). The catheter drive unit rotates and translates the catheter core (34) within the catheter sheath (36). The sled has a serrated, conical drive unit interface (82), with a bag-piercing tip (86) mateable with a translator drive output (92) so that a sterile drape (112) enclosing the catheter drive unit is automatically pierced when the catheter drive unit is mounted to the sled. A control unit (6) is spaced apart from the catheter drive unit and provides power and commands to the catheter drive unit and receives information and data from the catheter drive unit. The rotator and translator drive motors (54, 90) are operated from both the control unit and the catheter drive unit. Both the control unit and catheter drive unit have translation displacement displays (10, 30).

    摘要翻译： 系统（2）包括导管驱动单元（22）和从其可移动地安装到导管驱动滑架（26）上的导管（24）。 导管驱动单元旋转并平移导管芯（34）在导管套（36）内。 滑板具有锯齿状的锥形驱动单元接口（82），具有与翻译器驱动输出（92）配合的穿刺尖端（86），使得当包括导管驱动单元的无菌悬垂（112）自动穿透时 导管驱动单元安装在滑轨上。 控制单元（6）与导管驱动单元间隔开，并向导管驱动单元提供电力和命令，并从导管驱动单元接收信息和数据。 旋转器和转换器驱动马达（54,90）从控制单元和导管驱动单元两者操作。 控制单元和导管驱动单元都具有平移位移显示器（10,30）。