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1.发明申请USE OF MONOCLONAL ANTIBODIES SPECIFIC TO THE O-ACETYLATED FORM OF GD2 GANGLIOSIDE FOR TREATMENT OF CERTAIN CANCERS 有权使用特定于GD2 GANGLIOSO的O-乙酰甲胺治疗某些癌症的单克隆抗体公开(公告)号：US20100150910A1
公开(公告)日：2010-06-17
申请号：US12445071
申请日：2007-10-10
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/3084 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The invention relates to the use of monoclonal antibodies that only recognise the O-acetylated form of the GD2 ganglioside, or fragments of said antibody, for the diagnosis and the treatment of cancers in which the cells express the O-acetylated GD2, said antibody or said fragment recognising the O-acetylated GD2 molecules expressed by the tumoral cells and not recognising the GD2 molecules expressed at the surface of the peripheral nerves, in order to increase the specificity of the diagnosis and reduce the toxicity of the treatments. The invention also relates to artificially modified antibodies advantageously used for treating and diagnosing cancers in which the cells express the O-acetylated GD2.
摘要翻译： 本发明涉及仅识别GD2神经节苷脂的O-乙酰化形式或所述抗体的片段的单克隆抗体用于诊断和治疗其中细胞表达O-乙酰化GD2的所述抗体或所述抗体的所述抗体或 所述片段识别由肿瘤细胞表达的O-乙酰化GD2分子，并且不识别在外周神经表面表达的GD2分子，以增加诊断的特异性并降低治疗的毒性。 本发明还涉及有利地用于治疗和诊断细胞表达O-乙酰化GD2的癌症的人造修饰的抗体。
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2.发明授权Use of monoclonal antibodies specific to the O-acetylated form of GD2 ganglioside for treatment of certain cancers 有权使用特异于O-乙酰化形式的GD2神经节苷脂的单克隆抗体用于治疗某些癌症公开(公告)号：US08951524B2
公开(公告)日：2015-02-10
申请号：US12445071
申请日：2007-10-10
CPC分类号： C07K16/3084 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The invention relates to the use of monoclonal antibodies that only recognise the O-acetylated form of the GD2 ganglioside, or fragments of said antibody, for the diagnosis and the treatment of cancers in which the cells express the O-acetylated GD2, said antibody or said fragment recognising the O-acetylated GD2 molecules expressed by the tumoral cells and not recognising the GD2 molecules expressed at the surface of the peripheral nerves, in order to increase the specificity of the diagnosis and reduce the toxicity of the treatments. The invention also relates to artificially modified antibodies advantageously used for treating and diagnosing cancers in which the cells express the O-acetylated GD2.
摘要翻译： 本发明涉及仅识别GD2神经节苷脂的O-乙酰化形式或所述抗体的片段的单克隆抗体用于诊断和治疗其中细胞表达O-乙酰化GD2的所述抗体或所述抗体的所述抗体或 所述片段识别由肿瘤细胞表达的O-乙酰化GD2分子，并且不识别在外周神经表面表达的GD2分子，以增加诊断的特异性并降低治疗的毒性。 本发明还涉及有利地用于治疗和诊断细胞表达O-乙酰化GD2的癌症的人造修饰的抗体。
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