公开(公告)号：US20130196317A1

公开(公告)日：2013-08-01

申请号：US13614391

申请日：2012-09-13

申请人： Stanley N. Lapidus ,  John F. Thompson ,  Doron Lipson ,  Patrice Milos ,  J. William Efcavitch ,  Stanley Letovsky

发明人： Stanley N. Lapidus ,  John F. Thompson ,  Doron Lipson ,  Patrice Milos ,  J. William Efcavitch ,  Stanley Letovsky

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q1/6869 ,  C12Q2600/156

摘要： The invention generally relates to methods for detecting fetal nucleic acids and methods for diagnosing fetal abnormalities. In certain embodiments, the invention provides methods for determining whether fetal nucleic acid is present in a maternal sample including obtaining a maternal sample suspected to include fetal nucleic acids, and performing a sequencing reaction on the sample to determine presence of at least a portion of a Y chromosome in the sample, thereby determining that fetal nucleic acid is present in the sample. In other embodiments, the invention provides methods for quantitative or qualitative analysis to detect fetal nucleic acid in a maternal sample, regardless of the ability to detect the Y chromosome, particularly for samples including normal nucleic acids from a female fetus.

公开(公告)号：US20130022977A1

公开(公告)日：2013-01-24

申请号：US13619039

申请日：2012-09-14

申请人： Stanley Lapidus ,  John F. Thompson ,  Doron Lipson ,  Patrice Milos ,  J. William Efcavitch ,  Stanley Letovsky

发明人： Stanley Lapidus ,  John F. Thompson ,  Doron Lipson ,  Patrice Milos ,  J. William Efcavitch ,  Stanley Letovsky

IPC分类号： C12Q1/68 ,  B82Y15/00

摘要： The invention generally relates to methods for detecting fetal nucleic acids and methods for diagnosing fetal abnormalities. In certain embodiments, the invention provides methods for determining whether fetal nucleic acid is present in a maternal sample including obtaining a maternal sample suspected to include fetal nucleic acids, and performing a sequencing reaction on the sample to determine presence of at least a portion of a Y chromosome in the sample, thereby determining that fetal nucleic acid is present in the sample. In other embodiments, the invention provides methods for quantitative or qualitative analysis to detect fetal nucleic acid in a maternal sample, regardless of the ability to detect the Y chromosome, particularly for samples including normal nucleic acids from a female fetus.

摘要翻译： 本发明一般涉及用于检测胎儿核酸的方法和用于诊断胎儿异常的方法。 在某些实施方案中，本发明提供了用于确定胎儿核酸是否存在于母体样品中的方法，包括获得怀疑包括胎儿核酸的母体样品，并对样品进行测序反应以确定至少部分 Y染色体，从而确定胎儿核酸存在于样品中。 在其它实施方案中，本发明提供用于定量或定性分析以检测母体样品中的胎儿核酸的方法，而不管检测Y染色体的能力，特别是对于包括来自雌性胎儿的正常核酸的样品的检测能力。

公开(公告)号：US20050059032A1

公开(公告)日：2005-03-17

申请号：US10741183

申请日：2003-12-19

申请人： Patrice Milos ,  Amy Mank-Seymour ,  Jodi Richmond ,  Aidan Power

发明人： Patrice Milos ,  Amy Mank-Seymour ,  Jodi Richmond ,  Aidan Power

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/156

摘要： The present invention features polymorphisms in genes encoding cardiac potassium channels that are predictive of a subject's susceptibility to developing a drug-induced arrhythmia. The present invention also provides methods of genotyping subjects to determine whether they carry the polymorphisms.

摘要翻译： 本发明的特征在于编码心脏钾通道的基因的多态性，其预测受试者对发展药物诱发的心律失常的易感性。 本发明还提供了对受试者进行基因分型以确定它们是否携带多态性的方法。