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    Chiral compound suitable as a catalyst for asymmetric transfer hydrogenation
    8.
    发明授权
    Chiral compound suitable as a catalyst for asymmetric transfer hydrogenation 有权
    适用于不对称转移氢化催化剂的手性化合物

    公开(公告)号：US07884223B2

    公开(公告)日：2011-02-08

    申请号：US11667381

    申请日：2005-11-10

    申请人： Johannes Gerardus (Hans) De Vries ,  Gerardus Karel Maria Verzijl ,  Andreas Hendrikus Maria De Vries ,  Vincent Ritleng ,  Adeline Marie Joseèphe Voelklin

    发明人： Johannes Gerardus (Hans) De Vries ,  Gerardus Karel Maria Verzijl ,  Andreas Hendrikus Maria De Vries ,  Vincent Ritleng ,  Adeline Marie Joseèphe Voelklin

    IPC分类号： C07F15/00 ,  B01J31/00

    CPC分类号： C07F17/02

    摘要： The invention relates to an enantiomerically enriched chiral compound comprising a transition metal M, which comprises four, five or six coordinating groups of which at least one pair is linked together to form a bidentate ligand, in which M is directly bound via one single σ-bond to a carbon atom of an optionally substituted and/or optionally fused (hetero)aromatic ring of said bidentate ligand and in which M is directly bound to a nitrogen atom of a primary or secondary amino group of said bidentate ligand, thereby forming a metallacycle between said bidentate ligand and the metal M, said metal M being selected from the metals of groups 8 and 9 of the Periodic Table of the Elements, in particular iron, ruthenium, osmium, cobalt, rhodium, or iridium. The chiral compound can be used as a catalyst, preferably in an asymmetric transfer hydrogenation process. The invention further relates to a process for an asymmetric transfer hydrogenation of a prochiral compound in the presence of a hydrogen donor and the chiral compound of the invention comprising a transition metal chosen from the metals of groups 8, 9 and 10 of the Periodic Table, in particular iron, ruthenium, osmium, cobalt, rhodium, iridium, nickel, palladium or platinum as the catalyst.

    摘要翻译： 本发明涉及包含过渡金属M的对映异构体富集的手性化合物，其包含四个，五个或六个配位基团，其中至少一对连接在一起形成双齿配体，其中M通过一个单一的直接结合; 与所述二齿配位体的任选取代的和/或任选稠合的（杂）芳族环的碳原子键合，并且其中M直接键合到所述二齿配位体的伯或仲氨基的氮原子上，从而形成 所述二齿配体和金属M之间的金属循环，所述金属M选自元素周期表第8和9族的金属，特别是铁，钌，锇，钴，铑或铱。 手性化合物可以用作催化剂，优选在不对称转移氢化方法中。 本发明还涉及在氢供体和含有选自元素周期表第8,9和10族的金属的过渡金属的本发明的手性化合物的存在下前手性化合物的不对称转移氢化的方法， 特别是铁，钌，锇，钴，铑，铱，镍，钯或铂作为催化剂。

    Process for the preparation of enantiomerically enriched esters and alcohols
    9.
    发明授权
    Process for the preparation of enantiomerically enriched esters and alcohols 失效
    用于制备对映体富集的酯和醇的方法

    公开(公告)号：US06841691B2

    公开(公告)日：2005-01-11

    申请号：US10296840

    申请日：2001-05-21

    申请人： Gerardus Karel Maria Verzijl ,  Johannes Gerardus Vries De ,  Quirinus Bernardus Broxterman

    发明人： Gerardus Karel Maria Verzijl ,  Johannes Gerardus Vries De ,  Quirinus Bernardus Broxterman

    IPC分类号： C07B53/00 ,  C07B55/00 ,  C07C29/143 ,  C07C33/20 ,  C12P41/00 ,  C11G3/00

    CPC分类号： C12P41/004

    摘要： Method for the preparation of an enantiomerically enriched ester, in which a mixture of the enantiomers of the corresponding secondary alcohol is subjected, in the presence of an acyl donor, to an enantioselective conversion in the presence of a racemisation catalyst upon which the ester is formed and an acyl donor residue is obtained, and in which the acyl donor residue is irreversibly removed from the phase in which the enantioselective conversion takes place. Preferably the enantioselective conversion is carried out enzymatically and a transfer hydrogenation catalyst is used as racemisation catalyst.The secondary alcohol can be formed in situ from the corresponding ketone, in the presence of a hydrogen donor. It is also possible to use a mixture of the secondary alcohol and the corresponding ketone as substrate.Preferably the acyl donor is chosen so that the acyl donor residue is converted in situ into another compound and/or the acyl donor residue is removed via distillation under reduced pressure.The enantiomerically enriched esters obtained can subsequently be converted into the corresponding enantiomerically enriched alcohols, which are desirable intermediate products in the preparation of liquid crystals, agro chemicals or pharmaceuticals.

    摘要翻译： 制备对映异构体富集的酯的方法，其中将相应的仲醇的对映异构体的混合物在酰基供体的存在下在形成酯的外消旋催化剂存在下进行对映选择性转化 并且获得酰基供体残基，并且其中酰基供体残基从其中进行对映选择性转化的相不可逆地除去。 优选地，对映选择性转化酶进行酶促转移氢化催化剂作为外消旋化催化剂。仲醇可以在氢供体存在下由相应的酮原位形成。 还可以使用仲醇和相应的酮的混合物作为底物。优选地选择酰基供体，使得酰基供体残基原位转化成另一种化合物和/或通过蒸馏除去酰基供体残留物 所得到的对映异构体富集的酯可以随后转化成相应的对映异构体富集的醇，这在制备液晶，农用化学品或药物中是理想的中间产物。