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公开(公告)号:US08058475B2
公开(公告)日:2011-11-15
申请号:US12143433
申请日:2008-06-20
申请人: Stefan Oberboersch , Beatrix Merla , Bernd Sundermann , Werner Englberger , Hagen-Heinrich Hennies , Achim Kless , Petra Bloms-Funke , Babette-Yvonne Koegel , Heinze Graubaum
发明人: Stefan Oberboersch , Beatrix Merla , Bernd Sundermann , Werner Englberger , Hagen-Heinrich Hennies , Achim Kless , Petra Bloms-Funke , Babette-Yvonne Koegel , Heinze Graubaum
IPC分类号: C07C251/34 , A61K31/15
CPC分类号: C07C211/26 , C07C211/29 , C07C211/40 , C07C233/06 , C07C233/13 , C07C233/18 , C07C233/65 , C07C233/66 , C07C233/73 , C07C251/42 , C07C251/44 , C07C275/26 , C07C311/20 , C07C311/29 , C07C2601/08 , C07C2601/14 , C07C2603/74 , C07D209/14 , C07D333/14 , C07D333/22 , C07D409/12
摘要: Novel cyclohexylmethyl compounds corresponding to formula I wherein R1, R2, R3, R4 and R5, have the meanings given in the description. Pharmaceutical formulations containing these compounds, as well as a processes for preparing these compounds and related methods of treatment are also provided.
摘要翻译: 对应于式I的新型环己基甲基化合物,其中R 1,R 2,R 3,R 4和R 5具有在说明书中给出的含义。 还提供了含有这些化合物的药物制剂,以及制备这些化合物的方法和相关的治疗方法。
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公开(公告)号:US20090111842A1
公开(公告)日:2009-04-30
申请号:US12258936
申请日:2008-10-27
申请人: Beatrix Merla , Stefan Oberboersch , Bernd Sundermann , Werner Englberger , Hagen-Heinrich Hennies , Babette-Yvonne Koegel , Stephan Schunk , Heinz Graubaum
发明人: Beatrix Merla , Stefan Oberboersch , Bernd Sundermann , Werner Englberger , Hagen-Heinrich Hennies , Babette-Yvonne Koegel , Stephan Schunk , Heinz Graubaum
IPC分类号: A61K31/438 , C07D471/10 , A61K31/407 , C07D491/107 , A61P25/00
CPC分类号: C07D493/10 , C07D471/10 , C07D491/10 , C07D495/10
摘要: Spirocyclic cyclohexane compounds corresponding to formula I a process for manufacturing such compounds, pharmaceutical compositions that contain such compounds, and the use of such spirocyclic cyclohexane compounds for the production of pharmaceuticals, and particularly for the treatment of pain.
摘要翻译: 对应于式I的螺环环己烷化合物是制备这种化合物的方法,含有这些化合物的药物组合物,以及这种螺环环己烷化合物在制备药物中的用途,特别是用于治疗疼痛。
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公开(公告)号:US08124788B2
公开(公告)日:2012-02-28
申请号:US12258936
申请日:2008-10-27
申请人: Beatrix Merla , Stefan Oberboersch , Bernd Sundermann , Werner Englberger , Hagen-Heinrich Hennies , Babette-Yvonne Koegel , Stephan Schunk , Heinz Graubaum
发明人: Beatrix Merla , Stefan Oberboersch , Bernd Sundermann , Werner Englberger , Hagen-Heinrich Hennies , Babette-Yvonne Koegel , Stephan Schunk , Heinz Graubaum
IPC分类号: C07D209/56 , A61K31/404
CPC分类号: C07D493/10 , C07D471/10 , C07D491/10 , C07D495/10
摘要: Spirocyclic cyclohexane compounds corresponding to formula I a process for manufacturing such compounds, pharmaceutical compositions that contain such compounds, and the use of such spirocyclic cyclohexane compounds for the production of pharmaceuticals, and particularly for the treatment of pain.
摘要翻译: 对应于式I的螺环环己烷化合物是制备这种化合物的方法,含有这些化合物的药物组合物,以及这种螺环环己烷化合物在制备药物中的用途,特别是用于治疗疼痛。
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公开(公告)号:US20050192333A1
公开(公告)日:2005-09-01
申请号:US11019372
申请日:2004-12-23
申请人: Claudia Hinze , Bernd Sundermann , Stefan Oberboersch , Werner Englberger , Elmark Friderichs , Sven Frormann , Babette-Yvonne Koegel , Klaus Linz , Beatrix Merla , Derek Saunders , Wolfgang Schroeder , Hans Schick , Birgitta Henkel , Helmut Sonnenschein
发明人: Claudia Hinze , Bernd Sundermann , Stefan Oberboersch , Werner Englberger , Elmark Friderichs , Sven Frormann , Babette-Yvonne Koegel , Klaus Linz , Beatrix Merla , Derek Saunders , Wolfgang Schroeder , Hans Schick , Birgitta Henkel , Helmut Sonnenschein
IPC分类号: C07D471/10 , C07D491/10 , C07D495/10 , A61K31/407
CPC分类号: C07D471/10 , C07D491/10 , C07D495/10
摘要: Spirocyclic cyclohexane compounds, methods for their production, pharmaceutical compositions containing these compounds, and the use of these spirocyclic cyclohexane compounds for treating conditions associated with the nociceptin/ORL1 receptor system, e.g. pain, drug withdrawal, anxiety, etc.
摘要翻译: 螺环环己烷化合物,其制备方法,含有这些化合物的药物组合物,以及这些螺环环己烷化合物用于治疗与伤害感受肽/ ORL1受体系统相关的病症的用途,例如, 疼痛,戒毒,焦虑等
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公开(公告)号:US07332519B2
公开(公告)日:2008-02-19
申请号:US11019372
申请日:2004-12-23
申请人: Claudia Hinze , Bernd Sundermann , Stefan Oberboersch , Werner Englberger , Elmark Friderichs , Sven Frormann , Babette-Yvonne Koegel , Klaus Linz , Beatrix Merla , Derek Saunders , Wolfgang Schroeder , Hans Schick , Birgitta Henkel , Helmut Sonnenschein
发明人: Claudia Hinze , Bernd Sundermann , Stefan Oberboersch , Werner Englberger , Elmark Friderichs , Sven Frormann , Babette-Yvonne Koegel , Klaus Linz , Beatrix Merla , Derek Saunders , Wolfgang Schroeder , Hans Schick , Birgitta Henkel , Helmut Sonnenschein
IPC分类号: A61K31/404 , C07D209/56
CPC分类号: C07D471/10 , C07D491/10 , C07D495/10
摘要: Spirocyclic cyclohexane compounds, methods for their production, pharmaceutical compositions containing these compounds, and the use of these spirocyclic cyclohexane compounds for treating conditions associated with the nociceptin/ORL1 receptor system, e.g. pain, drug withdrawal, anxiety, etc.
摘要翻译: 螺环环己烷化合物,其制备方法,含有这些化合物的药物组合物,以及这些螺环环己烷化合物用于治疗与伤害感受肽/ ORL1受体系统相关的病症的用途,例如, 疼痛,戒毒,焦虑等
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公开(公告)号:US08106055B2
公开(公告)日:2012-01-31
申请号:US12112406
申请日:2008-04-30
申请人: Stefan Oberboersch , Melanie Reich , Bernd Sundermann , Utz-Peter Jagusch , Beatrix Merla , Stefan Schunk , Werner Englberger , Timo Struenker , Hagen-Heinrich Hennies , Edward Bijsterveld , Fritz Theil , Heinz Graubaum
发明人: Stefan Oberboersch , Melanie Reich , Bernd Sundermann , Utz-Peter Jagusch , Beatrix Merla , Stefan Schunk , Werner Englberger , Timo Struenker , Hagen-Heinrich Hennies , Edward Bijsterveld , Fritz Theil , Heinz Graubaum
IPC分类号: A61K31/497 , A61K31/47 , C07D401/12 , C07D215/08
CPC分类号: C07D207/04 , C07C233/56 , C07C235/20 , C07C235/22 , C07C311/17 , C07C311/20 , C07C311/29 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D211/08 , C07D333/20 , C07D409/04
摘要: Substituted amide compounds corresponding to formula I: processes for preparing them, pharmaceutical compositions containing these compounds, and the use of substituted amide derivatives for the preparation of medicaments for the treatment of pain and various other conditions.
摘要翻译: 对应于式I的取代的酰胺化合物:其制备方法,含有这些化合物的药物组合物,以及使用取代的酰胺衍生物制备用于治疗疼痛和各种其它病症的药物。
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公开(公告)号:US07728028B2
公开(公告)日:2010-06-01
申请号:US12143566
申请日:2008-06-20
申请人: Beatrix Merla , Stefan Oberboersch , Bernd Sundermann , Werner Englberger , Hagen-Heinrich Hennies , Heinz Graubaum
发明人: Beatrix Merla , Stefan Oberboersch , Bernd Sundermann , Werner Englberger , Hagen-Heinrich Hennies , Heinz Graubaum
IPC分类号: A61K31/4164 , C07D233/06 , A61P25/30 , A61P25/24
CPC分类号: C07D233/28
摘要: Substituted imidazoline derivatives corresponding to Formula I: a method for producing them from substituted aldehyde compounds of Formula B: and the use of such imidazoline derivatives and aldehyde compounds to treat pain, depression, urinary incontinence, diarrhea, pruritus, alcohol and drug misuse, drug dependency, lethargy and/or anxiety.
摘要翻译: 对应于式I的取代的咪唑啉衍生物:由式B的取代的醛化合物制备它们的方法:以及使用这些咪唑啉衍生物和醛化合物来治疗疼痛,抑郁症,尿失禁,腹泻,瘙痒,酒精和药物滥用,药物 依赖,嗜睡和/或焦虑。
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公开(公告)号:US07608619B2
公开(公告)日:2009-10-27
申请号:US12143519
申请日:2008-06-20
申请人: Beatrix Merla , Stefan Oberboersch , Bernd Sundermann , Werner Englberger , Hagen-Heinrich Hennies , Heinz Graubaum
发明人: Beatrix Merla , Stefan Oberboersch , Bernd Sundermann , Werner Englberger , Hagen-Heinrich Hennies , Heinz Graubaum
IPC分类号: A61K31/5377 , A61K31/421 , A61K31/454 , C07D413/02 , C07D413/14 , C07D263/48
CPC分类号: C07D263/48 , C07D413/04 , C07D413/06 , C07D413/14
摘要: Substituted oxazole derivatives corresponding to formula I: a method for producing such compounds, pharmaceutical compositions containing such compounds, and the use of such compounds to treat pain, depression, urinary incontinence, diarrhoea, pruritus, alcohol and drug misuse, drug dependency, lethargy and/or anxiety.
摘要翻译: 对应于式I的取代的恶唑衍生物:制备这种化合物的方法,含有这些化合物的药物组合物,以及这些化合物用于治疗疼痛,抑郁症,尿失禁,腹泻,瘙痒,酒精和药物滥用,药物依赖性,嗜睡和 /或焦虑。
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公开(公告)号:US20090069330A1
公开(公告)日:2009-03-12
申请号:US12143519
申请日:2008-06-20
申请人: Beatrix Merla , Stefan Oberboersch , Bernd Sundermann , Werner Englberger , Hagen-Heinrich Hennies , Heinz Graubaum
发明人: Beatrix Merla , Stefan Oberboersch , Bernd Sundermann , Werner Englberger , Hagen-Heinrich Hennies , Heinz Graubaum
IPC分类号: A61K31/5377 , C07D413/14 , C07D413/02 , A61K31/421 , C07D263/48 , A61K31/454
CPC分类号: C07D263/48 , C07D413/04 , C07D413/06 , C07D413/14
摘要: Substituted oxazole derivatives corresponding to formula 1: a method for producing such compounds, pharmaceutical compositions containing such compounds, and the use of such compounds to treat pain, depression, urinary incontinence, diarrhoea, pruritus, alcohol and drug misuse, drug dependency, lethargy and/or anxiety.
摘要翻译: 对应于式1的取代的恶唑衍生物:制备这种化合物的方法,含有这些化合物的药物组合物,以及这些化合物用于治疗疼痛,抑郁症,尿失禁,腹泻,瘙痒,酒精和药物滥用,药物依赖性,嗜睡和 /或焦虑。
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公开(公告)号:US20080306084A1
公开(公告)日:2008-12-11
申请号:US12112406
申请日:2008-04-30
申请人: Stefan Oberboersch , Melanie Reich , Bernd Sundermann , Utz-Peter Jagusch , Beatrix Merla , Stefan Schunk , Werner Englberger , Timo Struenker , Hagen-Heinrich Hennies , Edward Bijsterveld , Fritz Theil , Heinz Graubaum
发明人: Stefan Oberboersch , Melanie Reich , Bernd Sundermann , Utz-Peter Jagusch , Beatrix Merla , Stefan Schunk , Werner Englberger , Timo Struenker , Hagen-Heinrich Hennies , Edward Bijsterveld , Fritz Theil , Heinz Graubaum
IPC分类号: A61K31/496 , C07D215/36 , A61K31/47 , C07D401/06
CPC分类号: C07D207/04 , C07C233/56 , C07C235/20 , C07C235/22 , C07C311/17 , C07C311/20 , C07C311/29 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D211/08 , C07D333/20 , C07D409/04
摘要: Substituted amide compounds corresponding to formula I: processes for preparing them, pharmaceutical compositions containing these compounds, and the use of substituted amide derivatives for the preparation of medicaments for the treatment of pain and various other conditions.
摘要翻译: 对应于式I的取代的酰胺化合物:其制备方法,含有这些化合物的药物组合物,以及使用取代的酰胺衍生物制备用于治疗疼痛和各种其它病症的药物。
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