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公开(公告)号:US08318769B2
公开(公告)日:2012-11-27
申请号:US12420488
申请日:2009-04-08
申请人: Stefan Oberboersch , Melanie Reich , Stefan Schunk , Michael Franz-Martin Engels , Ruth Jostock , Tieno Germann , Jean De Vry , Klaus Schiene , Sabine Hees
发明人: Stefan Oberboersch , Melanie Reich , Stefan Schunk , Michael Franz-Martin Engels , Ruth Jostock , Tieno Germann , Jean De Vry , Klaus Schiene , Sabine Hees
IPC分类号: C07D215/58 , C07D401/14 , C07D213/30 , C07D401/12 , C07D265/36 , A61K31/4709 , A61K31/4465 , A61K31/497 , A61K31/55 , A61K31/45 , A61K31/536 , A61P29/00 , A61P37/08 , A61P27/14 , A61P25/28 , A61P17/00 , A61P17/06 , A61P31/04
CPC分类号: C07D401/14
摘要: Substituted sulfonamide compounds corresponding to formula I: processes for the preparation thereof, pharmaceutical compositions containing these compounds, and the use of such substituted sulfonamide compounds in pharmaceutical compositions for the treatment and/or inhibition of pain and other conditions at least partly mediated by the bradykinin 1 receptor.
摘要翻译: 对应于式I的取代的磺酰胺化合物:其制备方法,含有这些化合物的药物组合物,以及这些取代的磺酰胺化合物在药物组合物中用于治疗和/或抑制至少部分缓激肽介导的疼痛和其它病症的用途 1受体。
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公开(公告)号:US20090264400A1
公开(公告)日:2009-10-22
申请号:US12420488
申请日:2009-04-08
申请人: Stefan Oberboersch , Melanie Reich , Stefan Schunk , Michael Franz-Martin Engels , Ruth Jostock , Tieno Germann , Jean De Vry , Klaus Schiene , Sabine Hees
发明人: Stefan Oberboersch , Melanie Reich , Stefan Schunk , Michael Franz-Martin Engels , Ruth Jostock , Tieno Germann , Jean De Vry , Klaus Schiene , Sabine Hees
IPC分类号: A61K31/4545 , C07D401/14 , A61K31/55 , A61P25/00
CPC分类号: C07D401/14
摘要: Substituted sulfonamide compounds corresponding to formula I: processes for the preparation thereof, pharmaceutical compositions containing these compounds, and the use of such substituted sulfonamide compounds in pharmaceutical compositions for the treatment and/or inhibition of pain and other conditions at least partly mediated by the bradykinin 1 receptor.
摘要翻译: 对应于式I的取代的磺酰胺化合物:其制备方法,含有这些化合物的药物组合物,以及这些取代的磺酰胺化合物在药物组合物中用于治疗和/或抑制至少部分缓激肽介导的疼痛和其它病症的用途 1受体。
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公开(公告)号:US20100317644A1
公开(公告)日:2010-12-16
申请号:US12862297
申请日:2010-08-24
申请人: Stefan OBERBOERSCH , Melanie Reich , Stefan Schunk , Sabine Hees , Ruth Jostock , Michael Franz-Martin Engels , Achim Kless , Thomas Christoph , Klaus Schiene , Tieno Germann , Edward Bijsterveld
发明人: Stefan OBERBOERSCH , Melanie Reich , Stefan Schunk , Sabine Hees , Ruth Jostock , Michael Franz-Martin Engels , Achim Kless , Thomas Christoph , Klaus Schiene , Tieno Germann , Edward Bijsterveld
IPC分类号: A61K31/397 , C07D211/34 , C07D401/12 , C07D403/12 , C07D471/04 , C07D407/14 , C07D413/14 , A61K31/445 , A61K31/40 , A61K31/197 , A61K31/472 , C07D207/48 , A61K31/405 , A61K31/4025 , A61K31/4535 , A61K31/47 , A61K31/496 , A61K31/4545 , A61K31/4375 , A61K31/5377 , C07C317/48 , A61P29/00 , A61P25/04 , A61P25/06 , A61P3/10 , A61P11/00 , A61P35/00 , C07D217/16 , C07D209/18 , C07D409/12 , C07D215/58 , C07D401/14 , A61P3/04
CPC分类号: C07D409/14 , C07D401/12 , C07D401/14 , C07D403/14 , C07D471/04
摘要: Substituted sulfonamide derivatives, a process for their preparation, pharmaceutical compositions containing these compounds, and to the use of substituted sulfonamide derivatives in the treatment or inhibition of pain and/or various disorders or disease states.
摘要翻译: 取代的磺酰胺衍生物,其制备方法,含有这些化合物的药物组合物,以及取代的磺酰胺衍生物在治疗或抑制疼痛和/或各种疾病或疾病状态中的用途。
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公开(公告)号:US08435978B2
公开(公告)日:2013-05-07
申请号:US12862297
申请日:2010-08-24
申请人: Stefan Oberboersch , Melanie Reich , Stefan Schunk , Sabine Hees , Ruth Jostock , Michael Franz-Martin Engels , Achim Kless , Thomas Christoph , Klaus Schiene , Tieno Germann , Edward Bijsterveld
发明人: Stefan Oberboersch , Melanie Reich , Stefan Schunk , Sabine Hees , Ruth Jostock , Michael Franz-Martin Engels , Achim Kless , Thomas Christoph , Klaus Schiene , Tieno Germann , Edward Bijsterveld
IPC分类号: A61K31/453 , A61K31/496 , A61K31/4709 , C07D401/00 , C07D401/14 , C07D221/02
CPC分类号: C07D409/14 , C07D401/12 , C07D401/14 , C07D403/14 , C07D471/04
摘要: Substituted sulfonamide derivatives, a process for their preparation, pharmaceutical compositions containing these compounds, and to the use of substituted sulfonamide derivatives in the treatment or inhibition of pain and/or various disorders or disease states.
摘要翻译: 取代的磺酰胺衍生物,其制备方法,含有这些化合物的药物组合物,以及取代的磺酰胺衍生物在治疗或抑制疼痛和/或各种疾病或疾病状态中的用途。
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公开(公告)号:US20100324009A1
公开(公告)日:2010-12-23
申请号:US12862271
申请日:2010-08-24
申请人: Stefan OBERBOERSCH , Melanie Reich , Stefan Schunk , Sabine Hees , Ruth Jostock , Michael Franz-Martin Engels , Achim Kless , Thomas Christoph , Klaus Schiene , Tieno Germann , Edward Bijsterveld
发明人: Stefan OBERBOERSCH , Melanie Reich , Stefan Schunk , Sabine Hees , Ruth Jostock , Michael Franz-Martin Engels , Achim Kless , Thomas Christoph , Klaus Schiene , Tieno Germann , Edward Bijsterveld
IPC分类号: A61K31/397 , C07D211/34 , C07D207/48 , C07C317/48 , C07D217/16 , C07D209/18 , C07D409/12 , C07D215/58 , C07D401/14 , C07D401/12 , C07D403/12 , C07D471/04 , C07D407/14 , C07D413/14 , A61K31/445 , A61K31/40 , A61K31/197 , A61K31/472 , A61K31/405 , A61K31/4025 , A61K31/4535 , A61K31/47 , A61K31/496 , A61K31/4545 , A61K31/4375 , A61K31/5377 , A61P29/00 , A61P25/04 , A61P25/06 , A61P3/10 , A61P11/00 , A61P35/00
CPC分类号: C07D409/14 , C07D401/12 , C07D401/14 , C07D403/14 , C07D471/04
摘要: Substituted sulfonamide derivatives, a process for their preparation, pharmaceutical compositions containing these compounds, and to the use of substituted sulfonamide derivatives in the treatment or inhibition of pain and/or various disorders or disease states.
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公开(公告)号:US08541573B2
公开(公告)日:2013-09-24
申请号:US12397771
申请日:2009-03-04
申请人: Stefan Oberboersch , Ruth Jostock , Klaus Schiene , Jean De Vry , Tieno Germann , Sabine Hees , Stefan Schunk , Melanie Reich
发明人: Stefan Oberboersch , Ruth Jostock , Klaus Schiene , Jean De Vry , Tieno Germann , Sabine Hees , Stefan Schunk , Melanie Reich
IPC分类号: A61K31/538 , A61K31/496 , C07D401/14 , C07D498/04
CPC分类号: C07D401/12 , C07D211/58 , C07D401/14
摘要: Substituted sulfonamide compounds corresponding to the formula I processes for the preparation thereof, pharmaceutical compositions containing these compounds and the use of substituted sulfonamide compounds for the preparation of pharmaceutical compositions for treating pain and other conditions at least partly mediated via the bradykinin 1 receptor.
摘要翻译: 对应于式I的取代磺酰胺化合物的制备方法,含有这些化合物的药物组合物和使用取代的磺酰胺化合物制备用于治疗至少部分通过缓激肽1受体介导的疼痛和其它病症的药物组合物。
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公开(公告)号:US20090298812A1
公开(公告)日:2009-12-03
申请号:US12397771
申请日:2009-03-04
申请人: Stefan Oberboersch , Ruth Jostock , Klaus Schiene , Jean De Vry , Tieno Germann , Sabine Hees , Stefan Schunk , Melanie Reich
发明人: Stefan Oberboersch , Ruth Jostock , Klaus Schiene , Jean De Vry , Tieno Germann , Sabine Hees , Stefan Schunk , Melanie Reich
IPC分类号: A61K31/55 , C07D401/14 , A61K31/497 , C07D401/02
CPC分类号: C07D401/12 , C07D211/58 , C07D401/14
摘要: Substituted sulfonamide compounds corresponding to the formula I processes for the preparation thereof, pharmaceutical compositions containing these compounds and the use of substituted sulfonamide compounds for the preparation of pharmaceutical compositions for treating pain and other conditions at least partly mediated via the bradykinin 1 receptor.
摘要翻译: 对应于式I的取代磺酰胺化合物的制备方法,含有这些化合物的药物组合物和使用取代的磺酰胺化合物制备用于治疗至少部分通过缓激肽1受体介导的疼痛和其它病症的药物组合物。
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公开(公告)号:US08580965B2
公开(公告)日:2013-11-12
申请号:US11873065
申请日:2007-10-16
申请人: Stefan Oberboersch , Melanie Reich , Stefan Schunk , Sabine Hees , Ruth Jostock , Michael Engels , Achim Kless , Thomas Christoph , Klaus Schiene , Tieno Germann , Edward Bijsterveld
发明人: Stefan Oberboersch , Melanie Reich , Stefan Schunk , Sabine Hees , Ruth Jostock , Michael Engels , Achim Kless , Thomas Christoph , Klaus Schiene , Tieno Germann , Edward Bijsterveld
IPC分类号: C07D211/52 , C07D401/02 , C07D409/04
CPC分类号: C07D409/12 , C07D211/38 , C07D211/52 , C07D401/04 , C07D401/12 , C07D409/04
摘要: Substituted sulfonamide compounds with bradykinin receptor (B1R) modulating activity; processes for the preparation thereof, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat or inhibit pain and/or other disorders and/or disease states.
摘要翻译: 具有缓激肽受体(B1R)调节活性的取代磺酰胺化合物; 其制备方法,包含这些化合物的药物组合物,以及使用这些化合物治疗或抑制疼痛和/或其它疾病和/或疾病状态的方法。
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公开(公告)号:US20080249128A1
公开(公告)日:2008-10-09
申请号:US11873065
申请日:2007-10-16
申请人: Stefan OBERBOERSCH , Melanie Reich , Stefan Schunk , Sabine Hees , Ruth Jostock , Michael Engels , Achim Kless , Thomas Christoph , Klaus Schiene , Tieno Germann , Edward Bijsterveld
发明人: Stefan OBERBOERSCH , Melanie Reich , Stefan Schunk , Sabine Hees , Ruth Jostock , Michael Engels , Achim Kless , Thomas Christoph , Klaus Schiene , Tieno Germann , Edward Bijsterveld
IPC分类号: A61K31/4545 , C07D409/14 , C07D401/14 , C07D401/04 , A61P25/00 , A61P11/00 , A61P29/00 , A61P3/10 , A61K31/4725 , C07D409/04 , C07D401/02
CPC分类号: C07D409/12 , C07D211/38 , C07D211/52 , C07D401/04 , C07D401/12 , C07D409/04
摘要: Substituted sulfonamide compounds with bradykinin receptor (B1R) modulating activity; processes for the preparation thereof, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat or inhibit pain and/or other disorders and/or disease states.
摘要翻译: 具有缓激肽受体(B1R)调节活性的取代磺酰胺化合物; 其制备方法,包含这些化合物的药物组合物,以及使用这些化合物治疗或抑制疼痛和/或其它疾病和/或疾病状态的方法。
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公开(公告)号:US08119805B2
公开(公告)日:2012-02-21
申请号:US12613974
申请日:2009-11-06
申请人: Melanie Reich , Stefan Schunk , Ruth Jostock , Sabine Hees , Tieno Germann , Michael Franz-Martin Engels
发明人: Melanie Reich , Stefan Schunk , Ruth Jostock , Sabine Hees , Tieno Germann , Michael Franz-Martin Engels
IPC分类号: C07D221/02 , C07D221/20 , C07D401/14 , C07D417/14 , C07D409/14 , C07D403/14 , A61K31/496 , A61K31/497 , A61K31/445
CPC分类号: C07D401/12 , C07D211/96 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/08 , C07D471/10
摘要: Substituted disulfonamide compounds corresponding to formula I: In which R1, R2, R3, R4a, R4b, R5a, R5b, R8, R9a, R9b, R10, R11, a, b, s, t and A have defined meanings, pharmaceutical compositions containing one or more such compounds, processes for preparing such compounds, and a method of using such compounds for the treatment or inhibition of pain and/or other conditions mediated by the bradykinin receptor 1 (BR1).
摘要翻译: 对应于式I的取代的二磺酰胺化合物:其中R1,R2,R3,R4a,R4b,R5a,R5b,R8,R9a,R9b,R10,R11,a,b,s,t和A具有定义的含义, 一种或多种这样的化合物,制备这些化合物的方法,以及使用这些化合物治疗或抑制由缓激肽受体1(BR1)介导的疼痛和/或其它病症的方法。
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