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公开(公告)号:US20070270401A1
公开(公告)日:2007-11-22
申请号:US11696892
申请日:2007-04-05
申请人: Steffen STEURER , Bodo BETZEMEIER , Darryl MCCONNELL , Thomas GERSTBERGER , Matthias GRAUERT , Matthias HOFFMANN , Maria IMPAGNATIELLO , Lars van der VEEN , Ulrike WEYER-CZERNILOFSKY
发明人: Steffen STEURER , Bodo BETZEMEIER , Darryl MCCONNELL , Thomas GERSTBERGER , Matthias GRAUERT , Matthias HOFFMANN , Maria IMPAGNATIELLO , Lars van der VEEN , Ulrike WEYER-CZERNILOFSKY
IPC分类号: A61K31/43 , A61K31/497 , C07D513/04
CPC分类号: C07D513/04
摘要: The present invention encompasses compounds of general formula (1) wherein R1 to R5 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
摘要翻译: 本发明包括通式(1)的化合物,其中R 1至R 5定义如权利要求1,其适用于治疗以过量或 异常细胞增殖,以及其用于制备具有上述性质的药物的用途。
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公开(公告)号:US20080081802A1
公开(公告)日:2008-04-03
申请号:US11696900
申请日:2007-04-05
申请人: Darryl MCCONNELL , Bodo BETZEMEIER , Thomas GERSTBERGER , Maria IMPAGNATIELLO , Steffen STEURER , Lars van der VEEN , Ulrike WEYER-CZERNILOFSKY
发明人: Darryl MCCONNELL , Bodo BETZEMEIER , Thomas GERSTBERGER , Maria IMPAGNATIELLO , Steffen STEURER , Lars van der VEEN , Ulrike WEYER-CZERNILOFSKY
IPC分类号: A61K31/00 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/497 , A61K31/535 , A61K31/54 , A61P43/00 , C07D211/32 , C07D217/00 , C07D279/10 , C07D401/00 , C07D413/00
CPC分类号: C07D513/04
摘要: The present invention encompasses compounds of general formula (1) wherein R1 to R6 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
摘要翻译: 本发明包括通式(1)的化合物,其中R 1至R 6定义如权利要求1,其适用于治疗以过量或 异常细胞增殖,以及其用于制备具有上述性质的药物的用途。
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公开(公告)号:US20130165439A1
公开(公告)日:2013-06-27
申请号:US13775601
申请日:2013-02-25
IPC分类号: A61K31/5377 , A61K45/06 , A61K31/496 , C07D471/04 , A61K31/437
CPC分类号: C07D471/04
摘要: The present invention encompasses compounds of general formula (I) wherein the groups R1 to R5 are defined as in claim 1, which are suitable for treating diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.
摘要翻译: 本发明包括通式(I)的化合物,其中R 1至R 5基团如权利要求1中所定义,其适用于治疗以细胞增殖过度或异常为特征的疾病,及其用于制备具有上述 属性。
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公开(公告)号:US20130023519A1
公开(公告)日:2013-01-24
申请号:US13357021
申请日:2012-01-24
IPC分类号: A61K31/5377 , C07D401/14 , A61K31/506 , A61P35/00 , C07D401/06 , A61K31/551 , A61K31/553 , C07D413/14 , C07D405/14
CPC分类号: C07D401/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要: 5-alkynyl-pyridine of general formula (I) their use as inhibitors of the activity of PI3Kalpha, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. The groups R1 to R6 and n have the meanings given in the claims and in the specification.
摘要翻译: 通式(I)的5-炔基 - 吡啶它们作为PI3Kα的活性抑制剂,含有它们的药物组合物的用途,以及它们作为治疗和/或预防以细胞增殖过多或异常为特征的疾病的药物的用途 病情如癌症。 基团R1至R6和n具有权利要求书和说明书中给出的含义。
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公开(公告)号:US20120028958A1
公开(公告)日:2012-02-02
申请号:US13012081
申请日:2011-01-24
IPC分类号: A61K31/553 , C07D401/14 , C07D417/14 , C07D491/113 , C07D471/10 , C07D487/04 , C07D405/14 , C07D471/04 , A61K31/5377 , A61K31/506 , A61K31/541 , A61K31/551 , A61K31/519 , A61P35/00 , A61P29/00 , A61P31/00 , A61P37/06 , C07D413/14
CPC分类号: C07D413/14 , C07D401/06 , C07D401/14 , C07D405/14 , C07D471/10 , C07D487/04 , C07D491/113 , C07D498/04
摘要: The present invention encompasses compounds of general formula (1) whereinR1 to R4 R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
摘要翻译: 本发明包括通式(1)的化合物,其中R 1 -R 4 R 3如权利要求1中所定义,其适用于治疗以细胞增殖过度或异常为特征的疾病,以及其用于制备具有上述药物的用途 提到的属性。
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公开(公告)号:US20120028952A1
公开(公告)日:2012-02-02
申请号:US13012082
申请日:2011-01-24
IPC分类号: A61K31/506 , C07D413/14 , A61K31/5377 , C07D401/14 , C07D405/14 , C07D409/14 , C07D471/04 , A61K31/553 , C07D417/14 , A61K31/541 , A61K31/55 , A61K31/551 , C07D471/10 , A61P35/00 , A61P31/00 , A61P29/00 , A61P37/06 , C07D401/06
CPC分类号: A61K31/553 , A61K31/495 , A61K31/506 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , C07D239/26 , C07D239/48 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/10 , C07D487/08
摘要: The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
摘要翻译: 本发明包括通式(1)的化合物,其中R 1至R 3如权利要求1中所定义,其适用于治疗以细胞增殖过度或异常为特征的疾病,以及其用于制备具有上述特征的药物的用途, 上述属性。
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公开(公告)号:US20140073621A1
公开(公告)日:2014-03-13
申请号:US14087179
申请日:2013-11-22
IPC分类号: C07D471/10 , C07D405/14 , C07D409/14 , C07D471/04 , C07D401/06 , C07D401/14
CPC分类号: A61K31/553 , A61K31/495 , A61K31/506 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , C07D239/26 , C07D239/48 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/10 , C07D487/08
摘要: The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
摘要翻译: 本发明包括通式(1)的化合物,其中R 1至R 3如权利要求1中所定义,其适用于治疗以细胞增殖过度或异常为特征的疾病,以及其用于制备具有上述特征的药物的用途, 上述属性。
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公开(公告)号:US20130023533A1
公开(公告)日:2013-01-24
申请号:US13357014
申请日:2012-01-24
IPC分类号: A61K31/506 , A61P35/00 , C07D413/14 , A61K31/5377 , C07D401/06 , C07D401/14
CPC分类号: C07D401/06 , C07D401/14 , C07D413/14
摘要: 5-alkynyl-pyridine of general formula (I) which are inhibitors of the activity of PI3K alpha, and their use in the treatment of diseases characterized by excessive or abnormal cell proliferation, such as cancer.
摘要翻译: 作为PI3Kα活性抑制剂的通式(I)的5-炔基 - 吡啶,以及它们用于治疗特征为过度或异常细胞增殖的疾病如癌症的用途。
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