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公开(公告)号:US07880000B2
公开(公告)日:2011-02-01
申请号:US11126000
申请日:2005-05-09
申请人: Stephanie D. Geuns-Meyer , Brian L. Hodous , Stuart C. Chaffee , Paul A. Tempest , Philip R. Olivieri , Rebecca E. Johnson , Brian K. Albrecht , Vinod F. Patel , Victor J. Cee , Joseph L. Kim , Steven Bellon , Xiaotian Zhu , Yuan Cheng , Ning Xi , Karina Romero , Hanh Nho Nguyen , Holly L. Deak
发明人: Stephanie D. Geuns-Meyer , Brian L. Hodous , Stuart C. Chaffee , Paul A. Tempest , Philip R. Olivieri , Rebecca E. Johnson , Brian K. Albrecht , Vinod F. Patel , Victor J. Cee , Joseph L. Kim , Steven Bellon , Xiaotian Zhu , Yuan Cheng , Ning Xi , Karina Romero , Hanh Nho Nguyen , Holly L. Deak
IPC分类号: C07D401/14 , C07D403/14 , A61K31/53 , A61K31/4427 , A61K31/506 , A61P19/02 , A61P35/00
CPC分类号: C07D213/73 , C07D239/42 , C07D401/04 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D471/04
摘要: The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other poliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.
摘要翻译: 本发明涉及具有通式I的化合物,其中A,B,D,E,G,H1-5和R1-4在本文中定义,以及能够调节各种蛋白激酶受体酶的合成中间体, 从而影响与这些激酶的活性相关的各种疾病状态和状况。 例如,这些化合物能够调节激酶,从而影响血管生成过程并治疗血管生成相关疾病和其它包括癌症和炎症的复发性疾病。 本发明还包括药物组合物,包括该化合物,以及治疗与蛋白激酶活性有关的疾病状态的方法。
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公开(公告)号:US08476434B2
公开(公告)日:2013-07-02
申请号:US12952156
申请日:2010-11-22
申请人: Stephanie D. Geuns-Meyer , Brian L. Hodous , Stuart C. Chaffee , Paul Tempest , Ning Xi , Phillip R. Olivieri , Joseph L. Kim , Steven Bellon , Xiaotian Zhu , Yuan Cheng , Brian K. Albrecht , Vinod F. Patel , Victor J. Cee , Karina Romero , Hanh Nho Nguyen , Holly L. Deak , Rebecca E. Johnson
发明人: Stephanie D. Geuns-Meyer , Brian L. Hodous , Stuart C. Chaffee , Paul Tempest , Ning Xi , Phillip R. Olivieri , Joseph L. Kim , Steven Bellon , Xiaotian Zhu , Yuan Cheng , Brian K. Albrecht , Vinod F. Patel , Victor J. Cee , Karina Romero , Hanh Nho Nguyen , Holly L. Deak , Rebecca E. Johnson
IPC分类号: C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , A61K31/4427 , A61K31/506 , A61K31/54 , A61P19/02 , A61P35/00
CPC分类号: C07D213/73 , C07D239/42 , C07D401/04 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D471/04
摘要: The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other proliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.
摘要翻译: 本发明涉及具有通式I的化合物,其中A,B,D,E,G,H1-5和R1-4在本文中定义,以及能够调节各种蛋白激酶受体酶的合成中间体, 从而影响与这些激酶的活性相关的各种疾病状态和状况。 例如,化合物能够调节激酶,从而影响血管发生过程并治疗血管生成相关疾病和其它增殖性疾病,包括癌症和炎症。 本发明还包括药物组合物,包括该化合物,以及治疗与蛋白激酶活性有关的疾病状态的方法。
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