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    Vaginal treatment composition
    1.
    发明申请
    Vaginal treatment composition 有权
    阴道治疗组合物

    公开(公告)号：US20070026074A1

    公开(公告)日：2007-02-01

    申请号：US11194064

    申请日：2005-07-29

    申请人： Stephanie Martin ,  Lei Huang ,  Shu-Ping Yang ,  Yanbin Huang ,  Julie Villanueva ,  Sharon Greene ,  Kelly Arehart ,  Curtis Sayre ,  Robert Johnson

    发明人： Stephanie Martin ,  Lei Huang ,  Shu-Ping Yang ,  Yanbin Huang ,  Julie Villanueva ,  Sharon Greene ,  Kelly Arehart ,  Curtis Sayre ,  Robert Johnson

    IPC分类号： A61K9/14 ,  A61K31/70 ,  A61K31/045

    CPC分类号： A61K9/0034 ,  A61K31/192 ,  A61K31/70 ,  A61K47/36

    摘要： A vaginal treatment composition that rapidly forms a gel when placed into contact with monovalent or polyvalent cations, such as sodium (Na+) and calcium (Ca2+) cations naturally found in vaginal mucosa, is provided. The gel may form in less than about 1 hour, in some embodiments less than about 1 minute, and in some embodiments, less than about 30 seconds. Among other things, such rapid gelation reduces the likelihood of leakage during use. In addition, because the gel may form intravaginally, it is more likely to retain its structure and shape over an extended period of time. In this manner, the gel may provide the prolonged release of a therapeutic agent that inhibits and/or treats vaginal infection. For instance, the gel may remain within the vagina for about 2 to about 48 hours to provide the desired effect.

    摘要翻译： 当与一价或多价阳离子接触时迅速形成凝胶的阴道处理组合物，例如天然存在的钠（Na +）+和钙（Ca 2+）+阳离子 提供阴道粘膜。 凝胶可以在小于约1小时，在一些实施方案中小于约1分钟，并且在一些实施方案中小于约30秒形成。 除此之外，这种快速凝胶化可降低使用过程中泄漏的可能性。 另外，因为凝胶可以阴道内形成，所以更可能在延长的时间段内保持其结构和形状。 以这种方式，凝胶可提供抑制和/或治疗阴道感染的治疗剂的延长释放。 例如，凝胶可以保留在阴道内约2至约48小时以提供期望的效果。

    Therapeutic agents for inhibiting and/or treating vaginal infection
    2.
    发明申请
    Therapeutic agents for inhibiting and/or treating vaginal infection 失效
    用于抑制和/或治疗阴道感染的治疗剂

    公开(公告)号：US20060105963A1

    公开(公告)日：2006-05-18

    申请号：US11194039

    申请日：2005-07-29

    申请人： Shu-Ping Yang ,  Lei Huang ,  Stephanie Martin ,  Julie Villanueva ,  Sharon Greene ,  Kelly Arehart ,  Curtis Sayre ,  Robert Johnson

    发明人： Shu-Ping Yang ,  Lei Huang ,  Stephanie Martin ,  Julie Villanueva ,  Sharon Greene ,  Kelly Arehart ,  Curtis Sayre ,  Robert Johnson

    IPC分类号： A61K31/70 ,  A61K31/045

    CPC分类号： A61K31/7004 ,  A61K9/0034 ,  A61K31/047

    摘要： A vaginal treatment composition that employs a therapeutic agent to inhibit and/or treat vaginal infection is provided. The therapeutic agent is capable of inhibiting and/or killing Gardnerella (e.g., Gardnerella vaginalis), Candida (e.g., Candida albicans), and/or Trichomonas (e.g., Trichomonas vaginalis) pathogens. Desirably, such antimicrobial efficacy is achieved without substantially inhibiting the growth of Lactobacillus acidophilus. For instance, sugars and/or sugar alcohols may be employed in the present invention as a therapeutic agent for inhibiting and/or treating vaginal infection. In one particular embodiment, D-xylitol is used as the therapeutic agent.

    摘要翻译： 提供了使用治疗剂抑制和/或治疗阴道感染的阴道治疗组合物。 治疗剂能够抑制和/或杀死加德纳（Gardnerella vaginalis），假丝酵母​​（例如白色假丝酵母）和/或毛滴虫（例如阴道毛滴虫）病原体。 理想地，实现了这样的抗微生物效能，而基本上不抑制嗜酸乳杆菌的生长。 例如，本发明中可以使用糖和/或糖醇作为抑制和/或治疗阴道感染的治疗剂。 在一个具体实施方案中，D-木糖醇用作治疗剂。

    Vaginal treatment composition containing xylitol
    3.
    发明授权
    Vaginal treatment composition containing xylitol 有权
    含有木糖醇的阴道治疗组合物

    公开(公告)号：US07786176B2

    公开(公告)日：2010-08-31

    申请号：US11194064

    申请日：2005-07-29

    申请人： Stephanie M. Martin ,  Lei Huang ,  Shu-Ping Yang ,  Yanbin Huang ,  Julie Villanueva ,  Sharon Linda Greene ,  Kelly Arehart ,  Curtis Sayre ,  Robert B. Johnson

    发明人： Stephanie M. Martin ,  Lei Huang ,  Shu-Ping Yang ,  Yanbin Huang ,  Julie Villanueva ,  Sharon Linda Greene ,  Kelly Arehart ,  Curtis Sayre ,  Robert B. Johnson

    IPC分类号： A61K31/045

    CPC分类号： A61K9/0034 ,  A61K31/192 ,  A61K31/70 ,  A61K47/36

    摘要： A vaginal treatment composition that rapidly forms a gel when placed into contact with monovalent or polyvalent cations, such as sodium (Na+) and calcium (Ca2+) cations naturally found in vaginal mucosa, is provided. The gel may form in less than about 1 hour, in some embodiments less than about 1 minute, and in some embodiments, less than about 30 seconds. Among other things, such rapid gelation reduces the likelihood of leakage during use. In addition, because the gel may form intravaginally, it is more likely to retain its structure and shape over an extended period of time. In this manner, the gel may provide the prolonged release of a therapeutic agent that inhibits and/or treats vaginal infection. For instance, the gel may remain within the vagina for about 2 to about 48 hours to provide the desired effect.

    摘要翻译： 提供了一种当与阴离子粘膜天然存在的单价或多价阳离子（例如钠（Na +）和钙（Ca 2+））阳离子接触时，迅速形成凝胶的阴道治疗组合物。 凝胶可以在小于约1小时，在一些实施方案中小于约1分钟，并且在一些实施方案中小于约30秒形成。 除此之外，这种快速凝胶化可降低使用过程中泄漏的可能性。 另外，因为凝胶可以阴道内形成，所以更可能在延长的时间段内保持其结构和形状。 以这种方式，凝胶可提供抑制和/或治疗阴道感染的治疗剂的延长释放。 例如，凝胶可以保留在阴道内约2至约48小时以提供期望的效果。

    Xylitol for treatment of vaginal infections
    4.
    发明授权
    Xylitol for treatment of vaginal infections 失效
    木糖醇用于治疗阴道感染

    公开(公告)号：US07619008B2

    公开(公告)日：2009-11-17

    申请号：US11194039

    申请日：2005-07-29

    申请人： Shu-Ping Yang ,  Lei Huang ,  Stephanie M. Martin ,  Julie Villanueva ,  Sharon Greene ,  Kelly Arehart ,  Curtis Sayre ,  Robert B. Johnson

    发明人： Shu-Ping Yang ,  Lei Huang ,  Stephanie M. Martin ,  Julie Villanueva ,  Sharon Greene ,  Kelly Arehart ,  Curtis Sayre ,  Robert B. Johnson

    IPC分类号： A61K31/045

    CPC分类号： A61K31/7004 ,  A61K9/0034 ,  A61K31/047

    摘要： A vaginal treatment composition that employs a therapeutic agent to inhibit and/or treat vaginal infection is provided. The therapeutic agent is capable of inhibiting and/or killing Gardnerella (e.g., Gardnerella vaginalis), Candida (e.g., Candida albicans), and/or Trichomonas (e.g., Trichomonas vaginalis) pathogens. Desirably, such antimicrobial efficacy is achieved without substantially inhibiting the growth of Lactobacillus acidophilus. For instance, sugars and/or sugar alcohols may be employed in the present invention as a therapeutic agent for inhibiting and/or treating vaginal infection. In one particular embodiment, D-xylitol is used as the therapeutic agent.

    摘要翻译： 提供了使用治疗剂抑制和/或治疗阴道感染的阴道治疗组合物。 治疗剂能够抑制和/或杀死加德纳（Gardnerella vaginalis），念珠菌（例如白色念珠菌）和/或滴虫（例如阴道毛滴虫）病原体。 理想地，实现了这样的抗微生物效能，而基本上不抑制嗜酸乳杆菌的生长。 例如，本发明中可以使用糖和/或糖醇作为抑制和/或治疗阴道感染的治疗剂。 在一个具体实施方案中，D-木糖醇用作治疗剂。

    Degradable therapeutic delivery device
    6.
    发明申请
    Degradable therapeutic delivery device 有权
    可降解治疗输送装置

    公开(公告)号：US20070243229A1

    公开(公告)日：2007-10-18

    申请号：US11405262

    申请日：2006-04-17

    申请人： Molly Smith ,  Kelly Arehart ,  Lei Huang ,  Shu-Ping Yang ,  Yanbin Huang

    发明人： Molly Smith ,  Kelly Arehart ,  Lei Huang ,  Shu-Ping Yang ,  Yanbin Huang

    IPC分类号： A61F2/02 ,  C08G63/91

    CPC分类号： A61K47/34 ,  A61F6/08 ,  A61K9/0036 ,  A61K31/00 ,  A61K31/19 ,  A61M31/002 ,  C08G63/12 ,  C08G63/16 ,  C08G63/914

    摘要： A biodegradable biodelivery device is disclosed. The biodelivery device is formed from a polymer comprising the reaction product of a polyol and a polyacid. When exposed to water, the polymer degrades through hydrolysis. Of particular advantage, the polymer can be formed so as to be elastic and flexible. In one embodiment, the polymer is formed into a vaginal insert. As the polymer degrades, the polymer releases acid to a vaginal environment for decreasing the pH of the environment.

    摘要翻译： 公开了一种可生物降解的生物输送装置。 生物输送装置由包含多元醇和多元酸的反应产物的聚合物形成。 当暴露于水时，聚合物通过水解降解。 特别有利的是，聚合物可以形成为具有弹性和柔性。 在一个实施方案中，聚合物形成阴道插入物。 当聚合物降解时，聚合物将酸释放到阴道环境中以降低环境的pH。

    Bacteria binding products
    9.
    发明申请
    Bacteria binding products 审中-公开
    细菌结合产品

    公开(公告)号：US20070134337A1

    公开(公告)日：2007-06-14

    申请号：US10583423

    申请日：2004-12-22

    申请人： Julie Villanueva ,  Curtis Sayre ,  Lei Huang ,  Kevin McGrath ,  Ning Wei

    发明人： Julie Villanueva ,  Curtis Sayre ,  Lei Huang ,  Kevin McGrath ,  Ning Wei

    IPC分类号： A61K9/14 ,  C12Q1/18 ,  B32B5/02

    CPC分类号： D06M11/45 ,  A61L2/02 ,  A61L2/232 ,  D01F1/103 ,  D06M11/79 ,  D06M15/55 ,  D06M15/61 ,  D06M23/08 ,  Y10T442/2525

    摘要： There is provided products for the removal of negatively charged particles like bacteria from surfaces. The products have a positive charge that may be developed through the use of cationic treatments. The product or substrate from which it is made may be dipped in an aqueous solution of a non-antimicrobial treatment having a positive charge and the excess solution squeezed out. Treatment of the resulting coated substrate with heat at a temperature and for a time sufficient adheres the coating to the substrate. Alternatively, a non-antimicrobial, cationically charged chemical may be imbedded in a substrate web such that it will bloom to the surface when the web is exposed to water. A suitable substrate web may be a pulp and synthetic fiber fabric made by coforming or hydroengling and may be a laminate including other layers. The treated substrate and product remove a substantial amount of the bacteria from a surface yet do not appreciably kill the bacteria. Harsh, oxidizing, chemicals are not used in the preparation of the products and so the products are mild in their effect on the user's skin. The removal of the bacteria, in contrast to killing the bacteria, does not encourage the bacteria to develop immunity to the treatment.

    摘要翻译： 提供了从表面除去带负电荷的颗粒如细菌的产品。 这些产品具有通过使用阳离子处理可以开发的正电荷。 可以将其制成的产品或基材浸渍在具有正电荷且过量溶液挤出的非抗微生物处理的水溶液中。 在一段温度和一段时间内用热量处理所得的涂覆的基材足以将涂层粘附到基材上。 或者，非抗微生物的带阳离子电荷的化学品可以嵌入在基材网中，使得当幅材暴露于水时，其将开花到表面。 合适的基材纤维网可以是通过共成型或水化加工制成的纸浆和合成纤维织物，并且可以是包括其它层的层压体。 经处理的底物和产物从表面除去大量的细菌，但不会明显杀死细菌。 苛刻，氧化，化学品不用于制备产品，因此产品对用户皮肤的影响温和。 与杀死细菌相反，细菌的去除不会鼓励细菌发挥对治疗的免疫力。

    Urogenital infection inhibition
    10.
    发明申请
    Urogenital infection inhibition 审中-公开
    泌尿生殖器感染抑制

    公开(公告)号：US20060127459A1

    公开(公告)日：2006-06-15

    申请号：US11012758

    申请日：2004-12-15

    申请人： Lei Huang ,  Shu-Ping Yang ,  Yanbin Huang

    发明人： Lei Huang ,  Shu-Ping Yang ,  Yanbin Huang

    IPC分类号： A61K31/765 ,  A61K9/70

    CPC分类号： A61K9/0034 ,  A61K9/0036 ,  A61K31/75 ,  A61K31/765

    摘要： There is provided compositions and methods to inhibit the adherence of pathogenic microorganisms to cells. The composition includes water soluble PEO/PEG polymers which may be hydrophilic or amphiphilic block copolymers. One example of a suitable composition is polyethylene glycol or polyethylene oxide with a chemical formula of H—(OCH2CH2)n-OH. Another example of a suitable composition is amphiphilic block copolymer with a chemical formula PEOm-Xp-PEOn, where PEO is —(OCH2CH2)n-O and X is PPO(—(OCH2CH2CH2)m-), or PLGA (poly(lactic-co-glycolic acid), or PMMA (polymethyl methacrylate), or PBO (polybutylene oxide). The pathogenic microorganism may be a bacterial, fungal, viral or trichomonial pathogen and the composition prevents adherence of the pathogenic microorganism in, for example, a urogenital tract of a mammal and aids in reducing malodor generation. The composition may be applied to vaginal health products like, for example, moisturizer, gel, jelly, cream, insert (tablet), ointment, foam. The composition may also be applied to a feminine hygiene product, like, for example, a tampon, feminine pad, feminine wipe or panty liners.

    摘要翻译： 提供了抑制致病微生物对细胞的粘附的组合物和方法。 该组合物包括可以是亲水性或两亲性嵌段共聚物的水溶性PEO / PEG聚合物。 合适组合物的一个实例是具有化学式为H-（OCH 2 CH 2）n -OH的聚乙二醇或聚环氧乙烷。 合适的组合物的另一个实例是具有化学式PEOm-Xp-PEOn的两亲嵌段共聚物，其中PEO是 - （OCH2CH2）nO，X是PPO（ - （OCH2CH2CH2）m-）或PLGA（聚（乳酸 - 乙醇酸）或PMMA（聚甲基丙烯酸甲酯）或PBO（聚环氧丁烷），病原微生物可以是细菌，真菌，病毒或毛滴虫病原体，并且该组合物可防止病原微生物在例如泌尿生殖道 哺乳动物，有助于减少恶臭的产生，该组合物可用于例如保湿剂，凝胶，果冻，霜剂，插入物（片剂），软膏，泡沫等阴道保健品，该组合物也可用于女性卫生 产品，例如，棉塞，女性衬垫，女性擦拭物或内裤衬里。