公开(公告)号：US08870883B2

公开(公告)日：2014-10-28

申请号：US13016774

申请日：2011-01-28

申请人： Robert Metzger ,  Stephen Brown ,  Garrett A. Sheffer

发明人： Robert Metzger ,  Stephen Brown ,  Garrett A. Sheffer

IPC分类号： A61B17/56 ,  A61B17/15 ,  A61B17/14 ,  A61B17/02

CPC分类号： A61B17/155 ,  A61B17/02 ,  A61B17/14 ,  A61B17/142 ,  A61B17/157

摘要： Various method and apparatuses may be used to perform a procedure, such as a resection of a portion of the anatomy for preparation of the implants of a prosthetic. Various resecting member, including saw blades having selected geometries and shapes, can be used to assist in the resection of an anatomy to provide for implantation of a prosthetic. In addition, a cutting block assembly may be used to guide the resecting member. The cutting block assembly may be moveably mounted relative to the portion to be resected.

摘要翻译： 可以使用各种方法和装置来执行手术，例如切除解剖结构的一部分以准备假体的植入物。 可以使用包括具有选定几何形状和形状的锯片的各种切除构件来辅助切除解剖结构以提供假体植入。 此外，可以使用切割块组件来引导切除部件。 切割块组件可相对于要切除的部分可移动地安装。

公开(公告)号：US08663956B2

公开(公告)日：2014-03-04

申请号：US13588322

申请日：2012-08-17

申请人： Sarah McFarland ,  Stephen Brown ,  Sheryl Luttringer

发明人： Sarah McFarland ,  Stephen Brown ,  Sheryl Luttringer

IPC分类号： C12N1/15

CPC分类号： C12N15/8243 ,  C12N9/88

摘要： Provided herein are host cells comprising carbonic anhydrase activity, wherein the cells are capable of producing C4-dicarboxylic acid. Also provided are methods of producing C4-dicarboxylic acid comprising (a) cultivating the host cells having carbonic anhydrase activity in a medium under suitable conditions to produce C4-dicarboxylic acid; and (b) recovering the C4-dicarboxylic acid.

摘要翻译： 本文提供了包含碳酸酐酶活性的宿主细胞，其中细胞能够产生C4-二羧酸。 还提供了生产C4-二羧酸的方法，其包括（a）在合适条件下培养在培养基中具有碳酸酐酶活性的宿主细胞以产生C4-二羧酸; 和（b）回收C4-二羧酸。

公开(公告)号：US08597180B2

公开(公告)日：2013-12-03

申请号：US13166878

申请日：2011-06-23

申请人： Thomas John Hector Copeland ,  Cormac O'Prey ,  Rebecca Ann Wilkins ,  Daniel Leonard Fuller ,  Stephen Brown ,  Christopher John Silk ,  Trevor Beckett

发明人： Thomas John Hector Copeland ,  Cormac O'Prey ,  Rebecca Ann Wilkins ,  Daniel Leonard Fuller ,  Stephen Brown ,  Christopher John Silk ,  Trevor Beckett

IPC分类号： A61B1/32

CPC分类号： A61B17/0218 ,  A61B17/3423 ,  A61B17/3431 ,  A61B17/3439 ,  A61B2017/0225 ,  A61B2017/3427 ,  A61B2017/3488

摘要： A surgical access assembly for positioning within an opening in tissue including an outer member positionable outside a patient and defining an opening therein to receive a surgical instrument. The outer member has a first portion and a second portion wherein at least one of the first and second portions is movable with respect to the other portion. The assembly also includes an inner member positionable within a patient and a flexible member extending between the inner member and outer member, wherein movement of one of the first and second portions of the outer member adjusts tension on the flexible member to retract tissue. A locking mechanism locks the outer member in a plurality of select expanded positions. The locking mechanism includes first engagement structure on the first portion engageable with the second portion and a slidable member movable to a locking position to retain the first and second portions in the select expanded position.

公开(公告)号：US08574886B2

公开(公告)日：2013-11-05

申请号：US13401663

申请日：2012-02-21

申请人： Regine Behr ,  William Widner ,  Maria Tang ,  Stephen Brown ,  Leslie Naggiar ,  Linda Sternberg

发明人： Alan Sloma ,  Regine Behr ,  William Widner ,  Maria Tang ,  David Sternberg ,  Stephen Brown

IPC分类号： C12N1/20 ,  C12N15/74 ,  C12N15/00 ,  C12P19/04 ,  C12P19/26 ,  C12P19/28 ,  C12P1/00 ,  C12P21/06 ,  C07H21/04

CPC分类号： C12P19/26 ,  C12N9/1051 ,  C12N15/52

摘要： The present invention relates to methods for producing a hyaluronic acid, comprising: (a) cultivating a Bacillus host cell under conditions suitable for production of the hyaluronic acid, wherein the Bacillus host cell comprises a nucleic acid construct comprising a hyaluronan synthase encoding sequence operably linked to a promoter sequence foreign to the hyaluronan synthase encoding sequence; and (b) recovering the hyaluronic acid from the cultivation medium. The present invention also relates to an isolated nucleic acid sequence encoding a hyaluronan synthase operon comprising a hyaluronan synthase gene and a UDP-glucose 6-dehydrogenase gene, and optionally one or more genes selected from the group consisting of a UDP-glucose pyrophosphorylase gene, UDP-N-acetylglucosamine pyrophosphorylase gene, and glucose-6-phosphate isomerase gene. The present invention also relates to isolated nucleic acid sequences encoding a UDP-glucose 6-dehydrogenase, UDP-glucose pyrophosphorylase, and UDP-N-acetylglucosamine pyrophosphorylase.

摘要翻译： 本发明涉及透明质酸的制备方法，其包括：（a）在适于产生透明质酸的条件下培养芽孢杆菌属宿主细胞，其中所述芽孢杆菌宿主细胞包含可操作地连接的透明质酸合酶编码序列的核酸构建体 涉及透明质酸合酶编码序列外源的启动子序列; 和（b）从培养基中回收透明质酸。 本发明还涉及编码包含透明质酸合酶基因和UDP-葡萄糖-6-脱氢酶基因的透明质酸合酶操纵子的分离的核酸序列，以及任选地一种或多种选自UDP-葡萄糖焦磷酸化酶基因， UDP-N-乙酰葡糖胺焦磷酸化酶基因和葡萄糖-6-磷酸异构酶基因。 本发明还涉及编码UDP-葡萄糖-6-脱氢酶，UDP-葡萄糖焦磷酸化酶和UDP-N-乙酰葡糖胺焦磷酸化酶的分离的核酸序列。

公开(公告)号：US20120041269A1

公开(公告)日：2012-02-16

申请号：US13166878

申请日：2011-06-23

申请人： Thomas John Hector Copeland ,  Cormac O'Prey ,  Rebecca Ann Wilkins ,  Daniel Leonard Fuller ,  Stephen Brown ,  Christopher John Silk ,  Trevor Beckett

发明人： Thomas John Hector Copeland ,  Cormac O'Prey ,  Rebecca Ann Wilkins ,  Daniel Leonard Fuller ,  Stephen Brown ,  Christopher John Silk ,  Trevor Beckett

IPC分类号： A61B1/32

CPC分类号： A61B17/0218 ,  A61B17/3423 ,  A61B17/3431 ,  A61B17/3439 ,  A61B2017/0225 ,  A61B2017/3427 ,  A61B2017/3488

摘要： A surgical access assembly for positioning within an opening in tissue including an outer member positionable outside a patient and defining an opening therein to receive a surgical instrument. The outer member has a first portion and a second portion wherein at least one of the first and second portions is movable with respect to the other portion. The assembly also includes an inner member positionable within a patient and a flexible member extending between the inner member and outer member, wherein movement of one of the first and second portions of the outer member adjusts tension on the flexible member to retract tissue. A locking mechanism locks the outer member in a plurality of select expanded positions. The locking mechanism includes first engagement structure on the first portion engageable with the second portion and a slidable member movable to a locking position to retain the first and second portions in the select expanded position.

摘要翻译： 一种用于定位在组织中的开口内的外科进入组件，包括可定位在患者外部并在其中限定其中的开口以接收外科器械的外部构件。 外部构件具有第一部分和第二部分，其中第一和第二部分中的至少一个可相对于另一部分移动。 组件还包括可定位在患者体内的内部构件和在内部构件和外部构件之间延伸的柔性构件，其中外部构件的第一和第二部分中的一个的运动调节柔性构件上的张力以缩回组织。 锁定机构将外部构件锁定在多个选择的扩张位置。 锁定机构包括可与第二部分接合的第一部分上的第一接合结构和可移动到锁定位置以将第一和第二部分保持在选择扩张位置的可滑动构件。

公开(公告)号：US20110144044A1

公开(公告)日：2011-06-16

申请号：US12654193

申请日：2009-12-14

申请人： Michael Kichuk ,  Jason Bell ,  Stephen Brown ,  Shan Chaudhuri

发明人： Michael Kichuk ,  Jason Bell ,  Stephen Brown ,  Shan Chaudhuri

IPC分类号： A61K31/704 ,  A61K31/715

CPC分类号： A61K31/715 ,  A23L29/219 ,  A23L33/105 ,  A23L33/175 ,  A23V2002/00 ,  A61K31/198 ,  A61K31/704 ,  A61K36/258 ,  A61K2300/00 ,  A23V2200/316 ,  A23V2250/032 ,  A23V2250/044 ,  A23V2250/0626 ,  A23V2250/0654 ,  A23V2250/1578 ,  A23V2250/161 ,  A23V2250/1618 ,  A23V2250/2108 ,  A23V2250/2124 ,  A23V2250/314 ,  A23V2250/5102 ,  A23V2250/54246 ,  A23V2250/54252 ,  A23V2250/641 ,  A23V2250/70 ,  A23V2250/7056 ,  A23V2250/706

摘要： The composition of a dietary supplement is provided for increasing post workout recovery, increasing replenishment and regaining energy following exercise. A method for achieving the same is also provided. The present composition comprises branched chain amino acids, caffeine and a source of carbohydrates including waxy maize. The dietary supplement may further comprise one or more of Ginseng providing ginsenoside saponins, and Fenugreek seeds providing 4-Hydroxyisoleucine.

摘要翻译： 提供膳食补充剂的组成，用于增加锻炼后恢复，增加运动后的补充和恢复能量。 还提供了实现该方法的方法。 本发明组合物包含支链氨基酸，咖啡因和碳水化合物源，包括蜡质玉米。 膳食补充剂可以进一步包含一种或多种提供人参皂甙皂苷的人参和提供4-羟基异亮氨酸的葫芦巴种子。

公开(公告)号：US07594208B1

公开(公告)日：2009-09-22

申请号：US11610392

申请日：2006-12-13

申请人： Terry Borer ,  Ian Chesal ,  James Schleicher ,  David Mendel ,  Mike Hutton ,  Boris Ratchev ,  Yaska Sankar ,  Babette van Antwerpen ,  Gregg Baeckler ,  Richard Yuan ,  Stephen Brown ,  Vaughn Betz ,  Kevin Chan

发明人： Terry Borer ,  Ian Chesal ,  James Schleicher ,  David Mendel ,  Mike Hutton ,  Boris Ratchev ,  Yaska Sankar ,  Babette van Antwerpen ,  Gregg Baeckler ,  Richard Yuan ,  Stephen Brown ,  Vaughn Betz ,  Kevin Chan

IPC分类号： G06F17/50 ,  G06F9/45

CPC分类号： G06F17/5045

摘要： Techniques for optimizing the placement and synthesis of a circuit design on a programmable integrated circuit are provided. The performance of a circuit design is analyzed after it has been compiled with different values for selected input parameters. The input parameter values that produce the best results for an output metric are then chosen to synthesis and place the circuit design on the programmable integrated circuit. In one embodiment, the values of the output metrics are averaged for all test compiles that share the same input parameters, but different seeds. In another embodiment, the compile with the best output metrics, as determined by the user, are selected. These techniques allow a user to automatically trade off compile-time to get a better-optimized circuit.

摘要翻译： 提供了用于优化可编程集成电路上的电路设计的放置和合成的技术。 在对已选择的输入参数编译不同的值后，对电路设计的性能进行分析。 然后选择为输出量度产生最佳结果的输入参数值，以将电路设计合成并将其放置在可编程集成电路上。 在一个实施例中，对于共享相同输入参数但是不同种子的所有测试编译器，对输出度量的值进行平均。 在另一个实施例中，选择由用户确定的具有最佳输出度量的编译。 这些技术允许用户自动交换编译时间以获得更优化的电路。

公开(公告)号：US20090075651A1

公开(公告)日：2009-03-19

申请号：US11887948

申请日：2006-04-10

申请人： Malcolm MacNaughtan ,  Christopher Ridgway Drane ,  Craig Andrew Scott ,  Stephen Brown

发明人： Malcolm MacNaughtan ,  Christopher Ridgway Drane ,  Craig Andrew Scott ,  Stephen Brown

IPC分类号： H04W4/00

CPC分类号： H04W64/00 ,  G01S5/0036 ,  G01S5/0252 ,  G01S5/14

摘要： Methods and systems for determining whether a mobile radio terminal is on or out of a zone in a radio communications network. The methods and systems provide for generating a profile representative of the zone using measurements taken by the mobile radio terminal and/or the network and/or using predicted values. A comparison is then made between subsequent measurements or values and the profile to make a determination as to whether the mobile radio terminal is in or out of the zone. The methods and systems are applicable to any zone-based application including differential call charging, security applications, buddy finder services, mobile gaming and location based services in general.

摘要翻译： 用于确定移动无线电终端是否在无线电通信网络中的区域之外的方法和系统。 所述方法和系统提供使用由移动无线电终端和/或网络进行的测量和/或使用预测值来生成代表该区域的简档。 然后在随后的测量或值和简档之间进行比较，以确定移动无线电终端是否在区域内或外。 方法和系统适用于任何基于区域的应用，包括差分呼叫计费，安全应用，好友查找器服务，移动游戏和基于位置的服务。

公开(公告)号：US07490060B2

公开(公告)日：2009-02-10

申请号：US09946742

申请日：2001-09-04

申请人： Stephen Brown ,  Angela Chen ,  Thomas N. DeSouza

发明人： Stephen Brown ,  Angela Chen ,  Thomas N. DeSouza

IPC分类号： G06Q40/00

CPC分类号： G06Q40/04

摘要： A system for processing transaction data associated with a market transaction is provided that includes a pre-processor module configured to receive transaction data and to create objects associated with the transaction data, a marketspace module connected to the pre-processor module and configured to hold the objects, and an execution engine connected to the marketspace module and configured to retrieve the objects from the marketspace module and to match at least one object to at least another object (based upon the pluggable algorithm).

摘要翻译： 提供了一种用于处理与市场交易相关联的交易数据的系统，其包括配置成接收交易数据并创建与交易数据相关联的对象的预处理器模块，连接到预处理器模块的市场空间模块，并且被配置为保持 对象和连接到市场空间模块并被配置为从市场空间模块检索对象并且将至少一个对象与至少另一个对象（基于可插入算法）相匹配的执行引擎。

公开(公告)号：US07401314B1

公开(公告)日：2008-07-15

申请号：US11148588

申请日：2005-06-09

申请人： Karl Schabas ,  Stephen Brown ,  Deshanand Singh ,  Terry Borer ,  Shawn Malhotra

发明人： Karl Schabas ,  Stephen Brown ,  Deshanand Singh ,  Terry Borer ,  Shawn Malhotra

IPC分类号： G06F17/50

CPC分类号： G06F17/5054

摘要： A method for designing a system on a target device utilizing field programmable gate arrays (FPGAs) includes duplicating a plurality of components in response to slack values associated with connections to the components in placement locations.

摘要翻译： 使用现场可编程门阵列（FPGA）在目标设备上设计系统的方法包括响应于与放置位置中的组件的连接相关联的松弛值复制多个组件。