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公开(公告)号:US07674819B2
公开(公告)日:2010-03-09
申请号:US11415935
申请日:2006-05-02
申请人: Stephen Douglas Barrett , Victor Fedij , Lain-Yen Hu , Donna M. Iula , Bruce A. Lefker , Raj Kumar Raheja , Karen Sexton , Jennifer Ann Van Camp
发明人: Stephen Douglas Barrett , Victor Fedij , Lain-Yen Hu , Donna M. Iula , Bruce A. Lefker , Raj Kumar Raheja , Karen Sexton , Jennifer Ann Van Camp
IPC分类号: A61K31/40 , C07D207/04
CPC分类号: C07D207/273 , C07D207/27 , C07D401/06 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要: The present invention is directed to a new class of benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
摘要翻译: 本发明涉及一类新的苯腈和它们作为雄激素受体调节剂的用途。 本发明的其它方面涉及这些化合物用于减少过量的皮脂分泌和刺激毛发生长的用途。
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公开(公告)号:US07799823B2
公开(公告)日:2010-09-21
申请号:US11557225
申请日:2006-11-07
申请人: Stephen Douglas Barrett , Victor Fedij , Lain-Yen Hu , Donna M Iula , Bruce A Lefker , Raj Kumar Raheja , Karen Sexton , Jennifer Ann Van Camp
发明人: Stephen Douglas Barrett , Victor Fedij , Lain-Yen Hu , Donna M Iula , Bruce A Lefker , Raj Kumar Raheja , Karen Sexton , Jennifer Ann Van Camp
IPC分类号: A61K31/4015 , C07D207/12
CPC分类号: C07D207/273 , C07D207/27 , C07D401/06 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要: The present invention is directed to a new class of benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
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公开(公告)号:US06900244B2
公开(公告)日:2005-05-31
申请号:US10444349
申请日:2003-05-23
申请人: Jennifer Ann Van Camp , James W. Malecha , Julie M. Miyashiro , Gary A. DeCrescenzo , Joe T. Collins , Monica J. Kalman
发明人: Jennifer Ann Van Camp , James W. Malecha , Julie M. Miyashiro , Gary A. DeCrescenzo , Joe T. Collins , Monica J. Kalman
IPC分类号: C07D295/18 , A61K31/136 , A61K31/165 , A61K31/198 , A61K31/216 , A61K31/222 , A61K31/223 , A61K31/351 , A61K31/40 , A61K31/401 , A61K31/4406 , A61K31/445 , A61K31/4468 , A61K31/47 , A61K31/5375 , A61P3/06 , A61P3/10 , A61P9/10 , A61P25/28 , C07C215/16 , C07C215/68 , C07C217/08 , C07C219/06 , C07C225/06 , C07C229/18 , C07C229/28 , C07C229/36 , C07C229/48 , C07C237/06 , C07C259/06 , C07D207/16 , C07D211/60 , C07D211/62 , C07D213/36 , C07D213/38 , C07D215/06 , C07D215/14 , C07D295/185 , C07D309/14 , C07D335/02 , C07C229/40 , A61K31/195 , C07C237/20
CPC分类号: C07D295/185 , C07C215/68 , C07C217/08 , C07C219/06 , C07C229/18 , C07C229/36 , C07C229/48 , C07C237/06 , C07C259/06 , C07C2601/08 , C07C2601/14 , C07D207/16 , C07D211/60 , C07D211/62 , C07D213/38 , C07D215/14 , C07D309/14 , C07D335/02
摘要: The present invention is directed to selective LXR modulators, small molecule compounds corresponding to Formula I and is further directed to a process of treating a condition in a mammal that is modulated by LXR using a therapeutically effective dose of a compound of Formula I.
摘要翻译: 本发明涉及选择性LXR调节剂,对应于式I的小分子化合物,并且还涉及使用治疗有效剂量的式I化合物治疗由LXR调节的哺乳动物状况的方法。
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公开(公告)号:US06828446B2
公开(公告)日:2004-12-07
申请号:US10327741
申请日:2002-12-23
申请人: Nizal S. Chandrakumar , Christopher R. Dalton , James W. Malecha , Michael B. Tollefson , Jennifer Ann Van Camp , Phillip B. Cox
发明人: Nizal S. Chandrakumar , Christopher R. Dalton , James W. Malecha , Michael B. Tollefson , Jennifer Ann Van Camp , Phillip B. Cox
IPC分类号: C07D31904
CPC分类号: C07D319/08 , C07C323/41 , C07C323/42 , C07C2601/02 , C07C2601/04 , C07D213/32 , C07D311/16 , C07D317/56 , C07D317/64 , C07D333/38 , C07D409/12
摘要: The present invention is directed to selective LXR modulators, small molecule compounds corresponding to Formula I and is further directed to a process of treating a condition in a mammal that is modulated by LXR using a therapeutically effective dose of a compound of Formula I.
摘要翻译: 本发明涉及选择性LXR调节剂,对应于式I的小分子化合物,并且还涉及使用治疗有效剂量的式I化合物治疗由LXR调节的哺乳动物状况的方法。
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公开(公告)号:US06822120B2
公开(公告)日:2004-11-23
申请号:US10445370
申请日:2003-05-23
申请人: Daniel P. Becker , Gary A. DeCrescenzo , James W. Malecha , Julie M. Miyashiro , Jennifer Ann Van Camp , Joe T. Collins
发明人: Daniel P. Becker , Gary A. DeCrescenzo , James W. Malecha , Julie M. Miyashiro , Jennifer Ann Van Camp , Joe T. Collins
IPC分类号: C07C31704
CPC分类号: C07C317/22 , C07C317/24
摘要: The present invention is directed to selective LXR modulators, small molecule compounds corresponding to Formula I and is further directed to a process of treating a condition in a mammal that is modulated by LXR using a therapeutically effective dose of a compound of Formula I.
摘要翻译: 本发明涉及选择性LXR调节剂,对应于式I的小分子化合物,并且还涉及使用治疗有效剂量的式I化合物治疗由LXR调节的哺乳动物状况的方法。
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