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公开(公告)号:US07842838B2
公开(公告)日:2010-11-30
申请号:US12545547
申请日:2009-08-21
申请人: Stephen E. Webber , Frank Ruebsam , Martin Tran , Peter Dragovich , Liansheng Li , Douglas Eric Murphy , David Kucera , Zhongxiang Sun , Chinh Viet Tran
发明人: Stephen E. Webber , Frank Ruebsam , Martin Tran , Peter Dragovich , Liansheng Li , Douglas Eric Murphy , David Kucera , Zhongxiang Sun , Chinh Viet Tran
IPC分类号: C07C303/00
CPC分类号: C07D487/04
摘要: The invention is directed to pyrro[1,2-b]pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
摘要翻译: 本发明涉及吡咯并[1,2-b]哒嗪酮化合物和含有可用于治疗丙型肝炎病毒感染的化合物的药物组合物。
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公开(公告)号:US07582754B2
公开(公告)日:2009-09-01
申请号:US12266190
申请日:2008-11-06
申请人: Stephen E. Webber , Frank Ruebsam , Martin Tran , Peter Dragovich , Liansheng Li , Douglas Eric Murphy , David Kucera , Zhongxiang Sun , Chinh Viet Tran
发明人: Stephen E. Webber , Frank Ruebsam , Martin Tran , Peter Dragovich , Liansheng Li , Douglas Eric Murphy , David Kucera , Zhongxiang Sun , Chinh Viet Tran
IPC分类号: C07D513/04 , A61K31/542 , A61K31/5415
CPC分类号: C07D487/04
摘要: The invention is directed to pyrro[1,2-b]pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
摘要翻译: 本发明涉及吡咯并[1,2-b]哒嗪酮化合物和含有可用于治疗丙型肝炎病毒感染的化合物的药物组合物。
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公开(公告)号:US07462611B2
公开(公告)日:2008-12-09
申请号:US11766697
申请日:2007-06-21
申请人: Frank Ruebsam , Martin Tran , Stephen E. Webber , Peter Dragovich , Liansheng Li , Douglas Murphy , David Kucera , Zhongxiang Sun , Chinh Viet Tran
发明人: Frank Ruebsam , Martin Tran , Stephen E. Webber , Peter Dragovich , Liansheng Li , Douglas Murphy , David Kucera , Zhongxiang Sun , Chinh Viet Tran
IPC分类号: C07D513/04 , A61K31/542 , A61K31/5415
CPC分类号: C07D487/04
摘要: The invention is directed to pyrro[1,2-b]pyridazinone compounds of Formula I and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus: wherein R4 is selected from Ring A is 5 or 6- membered aryl or heterocyclyl, and the remaining substituents are defined herein.
摘要翻译: 本发明涉及式I的吡咯并[1,2-b]哒嗪酮化合物和含有可用于治疗丙型肝炎病毒感染的化合物的药物组合物:其中R 4选自环A是5或6-元芳基或 杂环基,其余的取代基在本文中定义。
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公开(公告)号:US08097613B2
公开(公告)日:2012-01-17
申请号:US12481391
申请日:2009-06-09
IPC分类号: C07D513/04 , A61K31/542
CPC分类号: C07D513/04 , C07D417/04
摘要: The invention is directed to [1,2,4]thiadiazine 1,1-dioxide compounds of formula I wherein A is B is and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
摘要翻译: 本发明涉及其中A为B的式I的[1,2,4]噻二嗪1,1-二氧化物化合物和含有可用于治疗丙型肝炎病毒感染的化合物的药物组合物。
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公开(公告)号:US20080146625A1
公开(公告)日:2008-06-19
申请号:US11999670
申请日:2007-12-06
申请人: Steven Joseph Berthel , Robert Francis Kester , Douglas Eric Murphy , Thomas Jay Prins , Frank Ruebsam , Chinh Viet Tran , Dionisios Vourloumis
发明人: Steven Joseph Berthel , Robert Francis Kester , Douglas Eric Murphy , Thomas Jay Prins , Frank Ruebsam , Chinh Viet Tran , Dionisios Vourloumis
IPC分类号: A61K31/425 , C07D231/10 , A61K31/426 , C07D277/20 , A61P3/00 , A61K31/41 , C07D285/12
CPC分类号: C07D231/40 , C07D241/20 , C07D261/14 , C07D277/46 , C07D277/56 , C07D277/82 , C07D285/08 , C07D401/06
摘要: Disclosed herein are pyrazole glucokinase activators of the formula (I): that are useful for the treatment of metabolic diseases and disorders.
摘要翻译: 本文公开了式(I)的吡唑葡糖激酶活化剂:其可用于治疗代谢性疾病和病症。
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公开(公告)号:US07935699B2
公开(公告)日:2011-05-03
申请号:US11879935
申请日:2007-07-19
申请人: Steven Joseph Berthel , Robert Francis Kester , Douglas Eric Murphy , Thomas Jay Prins , Frank Ruebsam , Ramakanth Sarabu , Chinh Viet Tran , Dionisios Vourloumis
发明人: Steven Joseph Berthel , Robert Francis Kester , Douglas Eric Murphy , Thomas Jay Prins , Frank Ruebsam , Ramakanth Sarabu , Chinh Viet Tran , Dionisios Vourloumis
IPC分类号: A61K31/5377 , A61K31/415 , A61P3/00 , C07D231/00
CPC分类号: C07D231/40 , C07D405/12 , C07D413/06
摘要: Disclosed herein are pyrazole glucokinase activators of the formula (I) useful for the treatment of metabolic diseases and disorders, preferably diabetes mellitus.
摘要翻译: 本文公开了可用于治疗代谢性疾病和病症(优选糖尿病)的式(I)的吡唑葡糖激酶活化剂。
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公开(公告)号:US07902248B2
公开(公告)日:2011-03-08
申请号:US11999670
申请日:2007-12-06
申请人: Steven Joseph Berthel , Robert Francis Kester , Douglas Eric Murphy , Thomas Jay Prins , Frank Ruebsam , Chinh Viet Tran , Dionisios Vourloumis
发明人: Steven Joseph Berthel , Robert Francis Kester , Douglas Eric Murphy , Thomas Jay Prins , Frank Ruebsam , Chinh Viet Tran , Dionisios Vourloumis
IPC分类号: A61K31/415 , A61K31/428 , C07D231/10 , C07D277/20
CPC分类号: C07D231/40 , C07D241/20 , C07D261/14 , C07D277/46 , C07D277/56 , C07D277/82 , C07D285/08 , C07D401/06
摘要: Disclosed herein are pyrazole glucokinase activators of the formula (I): that are useful for the treatment of metabolic diseases and disorders.
摘要翻译: 本文公开了式(I)的吡唑葡糖激酶活化剂:其可用于治疗代谢性疾病和病症。
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公开(公告)号:US20080021032A1
公开(公告)日:2008-01-24
申请号:US11879935
申请日:2007-07-19
申请人: Steven Joseph Berthel , Robert Francis Kester , Douglas Eric Murphy , Thomas Jay Prins , Frank Ruebsam , Ramakanth Sarabu , Chinh Viet Tran , Dionisios Vourloumis
发明人: Steven Joseph Berthel , Robert Francis Kester , Douglas Eric Murphy , Thomas Jay Prins , Frank Ruebsam , Ramakanth Sarabu , Chinh Viet Tran , Dionisios Vourloumis
IPC分类号: A61K31/5377 , A61K31/415 , A61P3/00 , A61P3/10
CPC分类号: C07D231/40 , C07D405/12 , C07D413/06
摘要: Disclosed herein are pyrazole glucokinase activators of the formula (I) useful for the treatment of metabolic diseases and disorders, preferably diabetes mellitus.
摘要翻译: 本文公开了可用于治疗代谢性疾病和病症(优选糖尿病)的式(I)的吡唑葡糖激酶活化剂。
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公开(公告)号:US20140309432A1
公开(公告)日:2014-10-16
申请号:US14261325
申请日:2014-04-24
申请人: Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , Evan S. Krygowski , John O. Link , James Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila Zipfel
发明人: Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , Evan S. Krygowski , John O. Link , James Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila Zipfel
IPC分类号: C07F5/02 , C07D491/052
CPC分类号: C07D491/052 , A61K31/4188 , A61K31/7056 , A61K31/7064 , A61K31/7072 , A61K38/06 , A61K38/07 , A61K38/21 , A61K45/06 , A61K47/60 , C07D405/12 , C07F5/025 , Y10S514/894 , A61K2300/00
摘要: The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号:US09156823B2
公开(公告)日:2015-10-13
申请号:US13884578
申请日:2011-11-16
申请人: Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , Evan S. Krygowski , John O. Link , James Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila Zipfel
发明人: Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , Evan S. Krygowski , John O. Link , James Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila Zipfel
IPC分类号: C07D403/14 , A61K31/4184 , C07D491/113 , A61K31/5377 , C07D491/107 , A61K31/4188 , A61K31/4178 , A61K45/06 , C07D405/14 , C07D417/14 , C07D471/08 , C07D491/10 , C07D493/04 , C07D495/04 , C07D513/04
CPC分类号: C07D403/14 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61K31/5377 , A61K45/06 , C07D405/14 , C07D417/14 , C07D471/08 , C07D491/10 , C07D491/107 , C07D491/113 , C07D493/04 , C07D495/04 , C07D513/04 , A61K2300/00
摘要: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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