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公开(公告)号:US08501712B2
公开(公告)日:2013-08-06
申请号:US13453682
申请日:2012-04-23
申请人: Stephen J. Baker , Virginia Sanders , Tsutomu Akama , Carolyn Bellinger-Kawahara , Yvonne Freund , Kirk R. Maples , Jacob J. Plattner , Yong-Kang Zhang , Huchen Zhou , Vincent S. Hernandez
发明人: Stephen J. Baker , Virginia Sanders , Tsutomu Akama , Carolyn Bellinger-Kawahara , Yvonne Freund , Kirk R. Maples , Jacob J. Plattner , Yong-Kang Zhang , Huchen Zhou , Vincent S. Hernandez
IPC分类号: A61K31/69
CPC分类号: A61K31/69 , C07F5/027 , Y02A50/411
摘要: Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.
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公开(公告)号:US08168614B2
公开(公告)日:2012-05-01
申请号:US11676120
申请日:2007-02-16
申请人: Stephen J. Baker , Virginia Sanders , Tsutomu Akama , Carolyn Bellinger-Kawahara , Yvonne Freund , Kirk R. Maples , Jacob J. Plattner , Yong-Kang Zhang , Huchen Zhou , Vincent S. Hernandez
发明人: Stephen J. Baker , Virginia Sanders , Tsutomu Akama , Carolyn Bellinger-Kawahara , Yvonne Freund , Kirk R. Maples , Jacob J. Plattner , Yong-Kang Zhang , Huchen Zhou , Vincent S. Hernandez
IPC分类号: A61K31/69
CPC分类号: A61K31/69 , C07F5/027 , Y02A50/411
摘要: Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.
摘要翻译: 公开了通过使用含硼小分子治疗抗炎症状况的方法。
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公开(公告)号:US20100267981A1
公开(公告)日:2010-10-21
申请号:US12629753
申请日:2009-12-02
申请人: Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Steven J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zegar , Yong-Kang Zhang , Huchen Zhou
发明人: Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Steven J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zegar , Yong-Kang Zhang , Huchen Zhou
IPC分类号: C07F5/02
CPC分类号: C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
摘要: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
摘要翻译: 本发明涉及可用于治疗真菌感染的化合物,更具体地涉及甲真菌病和/或皮肤真菌感染的局部治疗。 本发明涉及对真菌具有活性的化合物,并具有允许化合物与患者接触时达到感染真菌的皮肤,指甲,毛发,爪或蹄特定部位的性质。 特别地,本发明化合物具有促进钉板穿透的物理化学性质。
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公开(公告)号:US20130059803A1
公开(公告)日:2013-03-07
申请号:US13607321
申请日:2012-09-07
申请人: Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zagar , Yong-Kang Zhang , Huchen Zhou
发明人: Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zagar , Yong-Kang Zhang , Huchen Zhou
IPC分类号: A61K31/69 , A61P31/10 , A61K31/7028
CPC分类号: C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
摘要: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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公开(公告)号:US08115026B2
公开(公告)日:2012-02-14
申请号:US12629753
申请日:2009-12-02
申请人: Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Steven J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zegar , Yong-Kang Zhang , Huchen Zhou
发明人: Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Steven J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zegar , Yong-Kang Zhang , Huchen Zhou
IPC分类号: C07F5/04
CPC分类号: C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
摘要: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
摘要翻译: 本发明涉及可用于治疗真菌感染的化合物,更具体地涉及甲真菌病和/或皮肤真菌感染的局部治疗。 本发明涉及对真菌具有活性的化合物,并具有允许化合物与患者接触时达到感染真菌的皮肤,指甲,毛发,爪或蹄特定部位的性质。 特别地,本发明化合物具有促进钉板穿透的物理化学性质。
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公开(公告)号:US20130064783A1
公开(公告)日:2013-03-14
申请号:US13607405
申请日:2012-09-07
申请人: Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zagar , Yong-Kang Zhang , Huchen Zhou
发明人: Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zagar , Yong-Kang Zhang , Huchen Zhou
IPC分类号: C07F5/04 , A61K31/7076 , A61K31/70 , A61K31/69 , C07F5/06
CPC分类号: C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
摘要: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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公开(公告)号:US20130059802A1
公开(公告)日:2013-03-07
申请号:US13607250
申请日:2012-09-07
申请人: Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zagar , Yong-Kang Zhang , Huchen Zhou
发明人: Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zagar , Yong-Kang Zhang , Huchen Zhou
IPC分类号: A61K31/69 , A61P31/10 , A61K31/7034 , A61K31/7024 , A61K31/7076
CPC分类号: C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
摘要: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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公开(公告)号:US20120289686A1
公开(公告)日:2012-11-15
申请号:US13356488
申请日:2012-01-23
申请人: Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zagar , Yong-Kang Zhang , Huchen Zhou
发明人: Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zagar , Yong-Kang Zhang , Huchen Zhou
CPC分类号: C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
摘要: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
摘要翻译: 本发明涉及可用于治疗真菌感染的化合物,更具体地涉及甲真菌病和/或皮肤真菌感染的局部治疗。 本发明涉及对真菌具有活性的化合物,并具有允许化合物与患者接触时达到感染真菌的皮肤,指甲,毛发,爪或蹄特定部位的性质。 特别地,本发明化合物具有促进钉板穿透的物理化学性质。
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公开(公告)号:US08722917B2
公开(公告)日:2014-05-13
申请号:US13356488
申请日:2012-01-23
申请人: Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael Dipierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zagar , Yong-Kang Zhang , Huchen Zhou
发明人: Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael Dipierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zagar , Yong-Kang Zhang , Huchen Zhou
IPC分类号: C07F5/04
CPC分类号: C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
摘要: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
摘要翻译: 本发明涉及可用于治疗真菌感染的化合物,更具体地涉及甲真菌病和/或皮肤真菌感染的局部治疗。 本发明涉及对真菌具有活性的化合物,并具有允许化合物与患者接触时达到感染真菌的皮肤,指甲,毛发,爪或蹄特定部位的性质。 特别地,本发明化合物具有促进钉板穿透的物理化学性质。
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公开(公告)号:US20070293457A1
公开(公告)日:2007-12-20
申请号:US11676120
申请日:2007-02-16
申请人: Stephen Baker , Virginia Sanders , Tsutomu Akama , Carolyn Bellinger-Kawahara , Yvonne Freund , Kirk Maples , Jacob Plattner , Yong-Kang Zhang , Huchen Zhou , Vincent Hernandez
发明人: Stephen Baker , Virginia Sanders , Tsutomu Akama , Carolyn Bellinger-Kawahara , Yvonne Freund , Kirk Maples , Jacob Plattner , Yong-Kang Zhang , Huchen Zhou , Vincent Hernandez
CPC分类号: A61K31/69 , C07F5/027 , Y02A50/411
摘要: Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.
摘要翻译: 公开了通过使用含硼小分子治疗抗炎症状况的方法。
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