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    Catheter Having a Detachable Tip
    1.
    发明申请
    Catheter Having a Detachable Tip 失效
    导管有一个可拆卸的提示

    公开(公告)号：US20090264858A1

    公开(公告)日：2009-10-22

    申请号：US12107527

    申请日：2008-04-22

    申请人： Stephen Nash ,  Patricia O'Beirne ,  David Johnson ,  Stephen Gormley ,  Grace Kelly

    发明人： Stephen Nash ,  Patricia O'Beirne ,  David Johnson ,  Stephen Gormley ,  Grace Kelly

    IPC分类号： A61M31/00 ,  A61M25/00

    CPC分类号： A61M25/0069 ,  A61M2025/0057 ,  A61M2025/1093

    摘要： A catheter is disclosed that has a detachable tip for delivery of a therapeutic substance to a chronic total occlusion (CTO) within a body vessel. The tip is made from a biodegradable material and includes an active agent dispersed therethrough. The detachable tip pierces into the calcified lesion, detaches from the catheter, and remains embedded within the lesion as the tip degrades, thereby releasing the active agent. The active agent is a therapeutic substance effective to treat of a CTO. The active agent may be a drug, an enzyme, bacteria, or a parasite that degrades or softens the calcified lesion.

    摘要翻译： 公开了一种导管，其具有用于将治疗物质递送至体内容器内的慢性完全闭塞（CTO）的可拆卸末端。 尖端由可生物降解的材料制成并且包括分散在其中的活性剂。 可拆卸的尖端刺入钙化的病变，从导管分离，并且随着尖端降解而保持嵌入损伤内，从而释放活性剂。 活性剂是有效治疗CTO的治疗物质。 活性剂可以是降解或软化钙化病变的药物，酶，细菌或寄生虫。

    Catheter having a detachable tip
    2.
    发明授权
    Catheter having a detachable tip 失效
    导管具有可拆卸的尖端

    公开(公告)号：US08016799B2

    公开(公告)日：2011-09-13

    申请号：US12107527

    申请日：2008-04-22

    申请人： Stephen Nash ,  Patricia O'Beirne ,  David Johnson ,  Stephen Gormley ,  Grace Kelly

    发明人： Stephen Nash ,  Patricia O'Beirne ,  David Johnson ,  Stephen Gormley ,  Grace Kelly

    IPC分类号： A61M5/32

    CPC分类号： A61M25/0069 ,  A61M2025/0057 ,  A61M2025/1093

    摘要： A catheter is disclosed that has a detachable tip for delivery of a therapeutic substance to a chronic total occlusion (CTO) within a body vessel. The tip is made from a biodegradable material and includes an active agent dispersed therethrough. The detachable tip pierces into the calcified lesion, detaches from the catheter, and remains embedded within the lesion as the tip degrades, thereby releasing the active agent. The active agent is a therapeutic substance effective to treat of a CTO. The active agent may be a drug, an enzyme, bacteria, or a parasite that degrades or softens the calcified lesion.

    摘要翻译： 公开了一种导管，其具有用于将治疗物质递送至体内容器内的慢性完全闭塞（CTO）的可拆卸末端。 尖端由可生物降解的材料制成并且包括分散在其中的活性剂。 可拆卸的尖端刺入钙化的病变，从导管分离，并且随着尖端降解而保持嵌入损伤内，从而释放活性剂。 活性剂是有效治疗CTO的治疗物质。 活性剂可以是降解或软化钙化病变的药物，酶，细菌或寄生虫。

    SHAFTS WITH PRESSURE RELIEF IN CRYOTHERAPEUTIC CATHETERS AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS
    7.
    发明申请
    SHAFTS WITH PRESSURE RELIEF IN CRYOTHERAPEUTIC CATHETERS AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS 有权
    在压力导管和相关装置，系统和方法中的压力释放

    公开(公告)号：US20130289549A1

    公开(公告)日：2013-10-31

    申请号：US13458120

    申请日：2012-04-27

    申请人： Stephen Nash ,  Grace Kelly

    发明人： Stephen Nash ,  Grace Kelly

    IPC分类号： A61B18/02

    CPC分类号： A61B18/02 ,  A61B90/03 ,  A61B2018/00005 ,  A61B2018/00023 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/0268 ,  A61B2090/032 ,  A61B2090/037 ,  A61M25/1006 ,  A61M25/10184 ,  A61M25/1025 ,  A61M2025/1061 ,  F04C2270/041

    摘要： Cryotherapeutic systems with features that can facilitate pressure relief in the event of exhaust-passage blockage and associated devices, systems, and methods are disclosed herein. A cryotherapeutic system configured in accordance with a particular embodiment can include an elongated shaft having a distal portion and a pressure-relief portion proximal to the distal portion. The cryotherapeutic system can further include a supply lumen, an exhaust passage, and a balloon configured to receive refrigerant from the supply lumen and to exhaust refrigerant to the exhaust passage. The pressure-relief portion can be configured to release refrigerant from the exhaust passage when a pressure of refrigerant in the exhaust passage exceeds a threshold pressure less than a pressure rating of the balloon. The pressure-relief portion, for example, can include a rupture element configured to rupture at about the threshold pressure.

    摘要翻译： 本文公开了具有能够促进在排气通道堵塞的情况下的压力释放以及相关的装置，系统和方法的特征的冷冻治疗系统。 根据特定实施例构造的冷冻治疗系统可以包括细长轴，其具有远侧部分和靠近远端部分的压力释放部分。 冷冻治疗系统还可以包括供应管腔，排气通道和被配置为从供应管腔接纳制冷剂并将制冷剂排出到排气通道的气囊。 当排气通道中的制冷剂的压力超过小于气囊的额定压力的阈值压力时，减压部分可被构造成从排气通道释放制冷剂。 例如，减压部分可以包括构造成在约阈值压力下破裂的断裂元件。

    Shafts with pressure relief in cryotherapeutic catheters and associated devices, systems, and methods
    10.
    发明授权
    Shafts with pressure relief in cryotherapeutic catheters and associated devices, systems, and methods 有权
    在冷冻治疗导管和相关装置，系统和方法中具有压力释放的轴

    公开(公告)号：US09241752B2

    公开(公告)日：2016-01-26

    申请号：US13458120

    申请日：2012-04-27

    申请人： Stephen Nash ,  Grace Kelly

    发明人： Stephen Nash ,  Grace Kelly

    IPC分类号： A61B18/02 ,  A61M25/10 ,  A61B18/00 ,  A61B19/00

    CPC分类号： A61B18/02 ,  A61B90/03 ,  A61B2018/00005 ,  A61B2018/00023 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/0268 ,  A61B2090/032 ,  A61B2090/037 ,  A61M25/1006 ,  A61M25/10184 ,  A61M25/1025 ,  A61M2025/1061 ,  F04C2270/041

    摘要： Cryotherapeutic systems with features that can facilitate pressure relief in the event of exhaust-passage blockage and associated devices, systems, and methods are disclosed herein. A cryotherapeutic system configured in accordance with a particular embodiment can include an elongated shaft having a distal portion and a pressure-relief portion proximal to the distal portion. The cryotherapeutic system can further include a supply lumen, an exhaust passage, and a balloon configured to receive refrigerant from the supply lumen and to exhaust refrigerant to the exhaust passage. The pressure-relief portion can be configured to release refrigerant from the exhaust passage when a pressure of refrigerant in the exhaust passage exceeds a threshold pressure less than a pressure rating of the balloon. The pressure-relief portion, for example, can include a rupture element configured to rupture at about the threshold pressure.

    摘要翻译： 本文公开了具有能够促进在排气通道堵塞的情况下的压力释放以及相关的装置，系统和方法的特征的冷冻治疗系统。 根据特定实施例构造的冷冻治疗系统可以包括细长轴，其具有远侧部分和靠近远端部分的压力释放部分。 冷冻治疗系统还可以包括供应管腔，排气通道和被配置为从供应管腔接纳制冷剂并将制冷剂排出到排气通道的气囊。 当排气通道中的制冷剂的压力超过小于气囊的额定压力的阈值压力时，减压部分可被构造成从排气通道释放制冷剂。 例如，减压部分可以包括构造成在约阈值压力下破裂的断裂元件。